scholarly journals Dens evaginatus and dens invaginatus: A report of two cases

2020 ◽  
Vol 36 (82) ◽  
pp. 2091-2097
Author(s):  
Shruthi Hegde ◽  
Kamath Shanti ◽  
Vidya Ajila ◽  
Subhas Babu ◽  
Supriya Bhat
Keyword(s):  
Clinical Importance ◽  
Root Apex ◽  
Enamel Organ ◽  
Dental Papilla ◽  
Developmental Disturbances ◽  
Enamel Epithelium ◽  
Maxillary Lateral Incisor ◽  
Developmental Variations ◽  
Dens Invaginatus ◽  
Shape And Size

Introduction: Developmental disturbances of teeth at the stage of morpho-differentiation have been related to abnormalities associated with changes in the tooth shape and size. Dens evaginatus and dens invaginatus are the developmental variations of the human dentition. Dens evaginatus, a rare anomaly characterized by the presence of a tubercle on the occlusal surface of teeth is seen to occur due to abnormal proliferation and folding of the inner enamel epithelium and part of the dental papilla into the stellate reticulum of the enamel organ; whereas, dens invaginatus is seen to occur due to infolding of the enamel and dentine into the pulp cavity and sometimes extending to the root apex. Case report: We report cases with bilateral dens evaginatus in mandibular second premolars and dens invaginatus in maxillary lateral incisor. Conclusion: Such developmental anomalies of teeth deserve clinical importance, as high chances of early pulpal pathosis.

scholarly journals Dens Invaginatus: A Report of Two Cases

2021 ◽  
Vol 9 (01) ◽  
pp. 51-54
Author(s):  
Archna Agnihotri ◽  
Rosy Arora ◽  
Lalit Bida ◽  
Urvashi Sharma
Keyword(s):  
Enamel Organ ◽  
Developmental Origin ◽  
Dental Papilla ◽  
Canal Morphology ◽  
Dens Invaginatus

AbstractDens invaginatus (DI) is an anomaly of developmental origin arising due to disturbances during the morphodifferentiation stage, resulting from infolding of enamel organ toward the dental papilla. Different presentations of the invagination, altered canal morphology, and presence of constrictions and dilatations sometimes make its management really challenging. With the advent of modern diagnostic and treatment aids, their easy availability and routine use, it is now possible to have detailed view of the invagination, thus making the management easy and the outcome predictable. This article presents two different presentations of DI and their management.

Dens Invaginatus in Patients With Cleft Lip and Palate: A Case Series

2021 ◽  
pp. 105566562199853
Author(s):  
Ilana M. Ickow ◽  
Steven Zinn ◽  
J. Matthew Stacy ◽  
Brian Martin ◽  
Joseph E. Losee ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Case Series ◽  
Enamel Organ ◽  
Dental Anomaly ◽  
Maxillary Lateral Incisor ◽  
Dens Invaginatus ◽  
Pulp Treatment ◽  
Composite Restoration

Dens invaginatus is a rare developmental anomaly characterized by an infolding of the enamel organ within the crown or root of a tooth, and it is an example of a dental anomaly that has a higher incidence in patients with CL/P. If undiagnosed, dens invaginatus can lead to severe, acute pain and pulpal necrosis since it can permit direct entry of bacteria into the dental pulp. Treatment of dens invaginatus includes prophylactic sealant or composite restoration, endodontic therapy if pulpal involvement has already occurred, or extraction if aberrant tooth morphology precludes endodontic therapy. Few studies report on the incidence of dens invaginatus in patients with CL/P. The purpose of this article is to describe 4 cases of dens invaginatus in patients with CL/P which were encountered in a cleft-craniofacial orthodontic clinic. Each case describes dens invaginatus in a maxillary lateral incisor, and treatments ranged from sealant application to endodontic therapy to extraction. These cases highlight the importance of awareness of this dental anomaly among cleft team providers to facilitate early diagnosis in patients with CL/P.

Opg, Rank, and Rankl in Tooth Development: Co-ordination of Odontogenesis and Osteogenesis

2004 ◽  
Vol 83 (3) ◽  
pp. 241-244 ◽  
Author(s):  
A. Ohazama ◽  
J.-M. Courtney ◽  
P.T. Sharpe
Keyword(s):  
Tooth Development ◽  
Nuclear Factor Κb ◽  
Cellular Interactions ◽  
Rankl Expression ◽  
Dental Papilla ◽  
Spatiotemporal Expression ◽  
Receptor Activator ◽  
Explant Cultures ◽  
Enamel Epithelium ◽  
Tooth Germs

Osteoprotegerin (OPG), receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANKL) are mediators of various cellular interactions, including bone metabolism. We analyzed expression of these three genes during murine odontogenesis from epithelial thickening to cytodifferentiation stages. Opg showed expression in the thickening and bud epithelium. Expression of Opg and Rank was observed in both the internal and the external enamel epithelium as well as in the dental papilla mesenchyme. Although Rankl expression was not detected in tooth epithelium or mesenchyme, it was expressed in pre-osteogenic mesenchymal cells close to developing tooth germs. All three genes were detected in developing dentary bone at P0. The addition of exogenous OPG to explant cultures of tooth primordia produced a delay in tooth development that resulted in reduced mineralization. We propose that the spatiotemporal expression of these molecules in early tooth and bone primordia cells has a role in co-ordinating bone and tooth development.

scholarly journals Dentin matrix protein 1 (DMP1) expression in developing human teeth

2009 ◽  
Vol 20 (5) ◽  
pp. 365-369 ◽  
Author(s):  
Elizabeth Ferreira Martinez ◽  
Luciana Alves Herdy da Silva ◽  
Cristiane Furuse ◽  
Ney Soares de Araújo ◽  
Vera Cavalcanti de Araújo
Keyword(s):  
Dental Pulp ◽  
Matrix Protein ◽  
Enamel Organ ◽  
Dentin Matrix Protein 1 ◽  
Tooth Formation ◽  
Dentinal Tubules ◽  
Dental Lamina ◽  
Dentin Matrix Protein ◽  
Dental Papilla ◽  
Dentin Matrix

Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. The purpose of the present study was to examine the immunoexpression of DMP1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed tooth formation erupted teeth. The results showed the presence of DMP1 in the dental lamina, as well as in the cells of the external epithelium, stellate reticulum and stratum intermedium of the enamel organ. However, in the internal dental epithelium, cervical loop region and dental papilla some cells have not labeled for DMP1. In the crown stage, DMP1 was expressed in the ameloblast and odontoblast layer, as well as in the dentinal tubules of coronal dentin near the odontoblast area. Erupted teeth with complete tooth formation exhibited immunolabeling for DMP1 only in the dentinal tubules mainly close to the dental pulp. No staining was observed in the enamel, predentin or dental pulp matrix. DMP1 is present in all developing dental structures (dental lamina, enamel organ, dental papilla) presenting few immunoexpression variations, with no staining in mineralized enamel and dentin.

Lesions of the Enamel Organ of Developing Dog Teeth following Experimental Inoculation of Gnotobiotic Puppies with Canine Distemper Virus

1981 ◽  
Vol 18 (5) ◽  
pp. 684-689 ◽  
Author(s):  
R. R. Dubielzig ◽  
R. J. Higgins ◽  
S. Krakowka
Keyword(s):  
Canine Distemper Virus ◽  
Giant Cells ◽  
Enamel Organ ◽  
Post Inoculation ◽  
Canine Distemper ◽  
Experimental Inoculation ◽  
Enamel Epithelium ◽  
Viral Inclusions ◽  
Reduced Enamel Epithelium ◽  
Multinucleate Giant Cells

Ten 7-day-old gnotobiotic Beagle puppies were inoculated intraperitoneally with virulent canine distemper virus (R252-CDV). The dogs were killed and perfused with paraformaldehyde/glutaraldehyde from eight to 36 days after inoculation. The developing teeth of the mandibles were examined by light microscopy, and the teeth from three dogs were examined by electron microscopy. Necrosis of individual cells in the stratum intermedium of the developing tooth was the first change, detectable at day 9 post-inoculation. At day 16 post-inoculation, there was disorganization of the ameloblasts. In the stratum intermedium, multinucleate giant cells and large eosinophilic cytoplasmic viral inclusions were prominent. Ultrastructurally, these inclusions consisted of clusters of tubular aggregates typical of canine distemper virus nucleocapsids. At 28 to 36 days post-inoculation, the changes were seen in the reduced enamel epithelium. Multinucleate cells were seen, but no inclusions. Some necrotic cells were seen. In these teeth, ameloblastic cells of the root were morphologically normal. Our results suggest that distemper virus affects developing teeth by direct infection of the enamel organ.

Complex treatment of dens invaginatus type III in maxillary lateral incisor

1999 ◽  
Vol 15 (2) ◽  
pp. 88-90 ◽  
Author(s):  
I. C. Fröner ◽  
L. F. da Costa Rocha ◽  
W. F. Costa ◽  
V. M. da Rocha Barros ◽  
D. Morello
Keyword(s):  
Lateral Incisor ◽  
Complex Treatment ◽  
Type Iii ◽  
Maxillary Lateral Incisor ◽  
Dens Invaginatus

Tissue interactions in embryonic mouse tooth germs

Development ◽  
1970 ◽  
Vol 24 (1) ◽  
pp. 159-171
Author(s):  
Edward J. Kollar ◽  
Grace R. Baird
Keyword(s):  
Enamel Organ ◽  
Oral Epithelium ◽  
Embryonic Mouse ◽  
Tooth Shape ◽  
Structural Specificity ◽  
Dental Papilla ◽  
Tissue Interactions ◽  
Dental Epithelium ◽  
Tooth Germs

The ability of fragments of incisor enamel organ and lip-furrow epithelium from 15- and 16-day old embryonic mice to regulate into harmonious tooth constructions is described. The cervical loop and upper half portions of the incisor enamel organ were confronted with incisor or molar dental papillae. Similar combinations were made from lip-furrow epithelium and incisor or molar papillae. The cultures were grown in the anterior chambers of homologous host eyes. The epithelial fragments from the incisor enamel organ when associated with the dental papillae reconstruct teeth typical in all respects; enamel and dentin matrices are deposited. Lip-furrow epithelium arises from the oral epithelium and is temporally and spatially related to the incisor dental epithelium proper. This ectopic epithelium was confronted by incisor and molar papillae. Harmonious teeth developed in these explants. It is concluded that the ability of the dental papillae to elicit new cytodifferentiative and biochemical syntheses from the lip-furrow epithelium indicates that the dental papillae act inductively during tooth ontogeny. The shape of the teeth reconstructed from enamel organ fragments and lip-furrow epithelium were incisiform or molariform in response to the incisor or molar dental papillae. These data confirm the conclusion that the structural specificity for tooth shape resides in the dental papilla.

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