Age Related Histological Changes in Tunica Intima of Coronary Arteries in Relevance to the Atherosclerosis

2016 ◽  
Vol 10 (2) ◽  
pp. 168
Author(s):  
Sachin Shembekar ◽  
Meena Meshram
2004 ◽  
Vol 17 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Anna Csiszar ◽  
Zoltan Ungvari ◽  
Akos Koller ◽  
John G. Edwards ◽  
Gabor Kaley

Previously we demonstrated that aging in coronary arteries is associated with proinflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by enhancing endothelial apoptosis. To test this hypothesis we characterized proapoptotic alterations in the phenotype of coronary arteries of aged (26 mo old) and young (3 mo old) F344 rats. DNA fragmentation analysis and TUNEL assay showed that in aged vessels there was an approximately fivefold increase in the number of apoptotic endothelial cells. In aged coronary arteries there was an increased expression of TNFα, TNFβ, and caspase 9 (microarray, real-time PCR), as well as increased caspase 9 and caspase 3 activity, whereas expression of TNFR1, TNFα-converting enzyme (TACE), Bcl-2, Bcl-X(L), Bid, Bax, caspase 8, and caspase 3 were unchanged. In vessel culture (18 h) incubation of aged coronary arteries with a TNF blocking antibody or the NO donor S-nitroso-penicillamine (SNAP) decreased apoptotic cell death. Incubation of young arteries with exogenous TNFα increased caspase 9 activity and elicited endothelial apoptosis, which was attenuated by SNAP. Inhibition of NO synthesis in cultured young coronary arteries also induced apoptotic cell death and potentiated the apoptotic effect of TNFα. Thus we propose that age-related upregulation of TNFα and caspase 9 and decreased bioavailability of NO promote endothelial apoptosis in coronary arteries that may lead to impaired endothelial function and ischemic heart disease in the elderly.


2014 ◽  
Vol 76 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Akira YABUKI ◽  
Shinichiro YONESHIGE ◽  
Shin TANAKA ◽  
Masashi TSUJIO ◽  
Sawane MITANI ◽  
...  

1995 ◽  
Vol 13 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Hiroo Koike ◽  
Sadakazu Ejiri ◽  
Kooji Hanada ◽  
Hidehiro Ozawa

1997 ◽  
Vol 62 (2) ◽  
pp. 97-106 ◽  
Author(s):  
M Gottwald ◽  
E Gottwald ◽  
S Dhein

2008 ◽  
Vol 125 (2) ◽  
pp. 141-153 ◽  
Author(s):  
Yoshiyuki Tohno ◽  
Setsuko Tohno ◽  
Lili Laleva ◽  
Nutcharin Ongkana ◽  
Takeshi Minami ◽  
...  

2020 ◽  
Author(s):  
Q. Ni ◽  
H. Chen ◽  
Y. Tan ◽  
J. Qin ◽  
H. Wang ◽  
...  

Author(s):  
Swapna Ramakant Patil ◽  
Shilpa Dhote

Ayurveda, The science of life, since its origin is serving the mankind throughout in health & disease state of life. Shalakyatantra, one of its specialized branch deals with the science of Ophthalmology, Otorhinolaryngology, Orodental surgery & Head; was contributed and developed by Rajrishi Nimi, the King of Videha, who was a colleague of Atreya, Punarvasu, Dhanwantri, Bharadwaja, Kashyapa etc. The available literature related to this speciality is reproduced from original text of Nimitantra in Uttartantra of Sushruta samhita. Correlation of Tritiya Patalagata kach with modern science is varies according to different authors, but according to some it can be correlated with different stages of senile immature cataract after considering the signs and symptoms and histological changes in the lens.One of the oldest concepts is that precipitation, denaturation, coagulation or agglutination of soluble lens protein is responsible for lens opacification. Accordingly after considering signs and  symptoms, here correlating Kaphaja kach with Senile Immature Cataract. Senile immature Cataract is also called as age related Cataract. It is one of the major causes for the age related visual impairment and blindness. It affects 11.5- to 15.5 million persons worldwide. At certain age of life, opacification of lens starts in everyone’s eye which leads to gradual diminished vision or loss of vision. which means gradual opacification leads to cataract. According to modern science, senile immature cataract can be correlated with kaphaja kach. In modern science surgery is the only treatment available in cataract. In Ayurveda our Acharyas have mentioned various procedures like anjana, aschotana, pariseka, tarpana to delay kach or arrest the procedure of opacification. which can be useful in senile immature cataract.


2021 ◽  
Vol 4 (2) ◽  
pp. 108-119
Author(s):  
Abeer Madkour Mahmoud ◽  
Dorreia Abdallah Mohamed Zaghloul ◽  
Fatma Y. Meligy ◽  
Maha AA Fahmy

Arkus ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 195-197
Author(s):  
Hardi Darmawan

Normal arteries have three layers of structure, tunica intima, tunica media, and tunica adventitia. Intima tunica is the deepest layer of coronary arteries in which there are antithrombotic molecules such as heparin sulfate, thrombomodulin, and plasminogen activator. In addition, tunica intima also contains substances that regulate the contraction of tunica smooth muscle cell media, called nitric oxide (vasodilators) and prostacyclin (vasoconstrictors). Tunica intima and tunica media seem to be directly related to the atherosclerosis process. Meanwhile, the role of tunika adventisia is unknown. The accumulation of atherosclerotic lesions and hemodynamic stress factors and the degradation of extracellular matrix will cause susceptibility of atherosclerotic plaque fibrous capsules to rupture and form thrombus. Thrombus that occurs in the coronary condition causes acute coronary syndrome, characterized by typical symptoms such as chest pain depending on the thrombus formed. In studying acute coronary syndromes, of course it cannot be separated from understanding the physiology of coronary arteries and the process of atherosclerosis. Therefore, this article aims to briefly explain coronary physiology.


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