Development and Validation of Stability-indicating HPLC method for simultaneous estimation of Tenofovir, Emtricitabine and Efavirenz in fixed dose combination drug product

2018 ◽  
Vol 11 (1) ◽  
pp. 23
Author(s):  
P. Sreelatha ◽  
B. Rama Devi
Keyword(s):  
Drug Product ◽  
Hplc Method ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Simultaneous Estimation ◽  
Combination Drug ◽  
Stability Indicating ◽  
Dose Combination ◽  
Development And Validation

Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of dapagliflozin and saxagliptin in fixed-dose combination

2018 ◽  
Vol 42 (4) ◽  
pp. 2459-2466 ◽  
Author(s):  
N. Singh ◽  
P. Bansal ◽  
M. Maithani ◽  
Y. Chauhan
Keyword(s):  
Hplc Method ◽  
Fixed Dose ◽  
Simultaneous Estimation ◽  
Stability Indicating ◽  
Stability Indicating Method ◽  
Rp Hplc ◽  
Dose Combination ◽  
Development And Validation ◽  
Tablet Dosage

A simple and precise stability indicating method for the simultaneous estimation of dapagliflozin and saxagliptin in combined tablet dosage form was developed and validated using RP-HPLC.

scholarly journals Simultaneous estimation of Curcumin and Gefitinib in bulk by using RP-HPLC technique with PDA detector

2018 ◽  
Vol 10 (1) ◽  
pp. 1-8
Author(s):  
Sagar Kishor Savale
Keyword(s):  
Chromatographic Method ◽  
Method Development ◽  
Estimation Method ◽  
Hplc Method ◽  
Fixed Dose ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Dose Combination ◽  
Hplc Method Development ◽  
Development And Validation

Plan: RP-HPLC method development and validation for the simultaneous estimation of curcumin and Gefitinib in bulk. Preface: RP-HPLC chromatographic method the been widely employed in the determination of individual components in a mixture or fixed dose combination. For the ternary mixture containing Curcumin and Gefitinib, no chromatographic method for simultaneous evaluation has been reported so far. Thus our aim is to develop a simultaneous estimation method for curcumin and gefitinib by using an RP-HPLC method using a PDA detector. Methodology: The method was validated as per ICH guidelines. The recovery studies confirmed the accuracy and precision of the method. Outcome: The proposed method was found to be accurate, repeatability and consistent. It was successfully applied for the analysis of the drug in the marketed formulation and could be effectively used for the routine analysis of formulation containing the drug without any alteration in the chromatography conditions.

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