A Study of Nerve Conduction Velocity in Newly Diagnosed Hyperthyroid Females

2017 ◽  
Vol 5 (2) ◽  
pp. 28
Author(s):  
B Adikesavan ◽  
P Sangeetha
Author(s):  
Lalithamma A ◽  
Vadivel S ◽  
Johnson W ◽  
Jacob V ◽  
Chitra T

Objective: This observational study was conducted during the year 2016–2017 to assess the electrodiagnostic evidence of peripheral nerve dysfunction among newly diagnosed hypothyroid patients attending a tertiary care hospital and to find the effect of hormonal treatment after short duration. Methods: An observational study was conducted in 25 newly diagnosed hypothyroid patients with the age group of 20–60 were included. After obtaining informed consent, all participants were examined with electrodiagnostic workup performed at the initial time of diagnosis and after short duration for median and ulnar nerves of upper limb by (NeuroStim -NS2, EMG/EP/NCV, and MEDICAID SYSTEMS). Electrophysiological parameters such as distal motor latency, amplitude, and conduction velocity were evaluated. Results: The mean age of study population was 42.7±12.1 (23–61) years. The mean values of nerve conduction velocity of motor and sensory median before the treatment were 42.8±15.7 and 40.13±4.19 and motor and sensory ulnar before treatment were 41.18±22.4 and 39.46±11.9. The mean values of nerve conduction velocity of motor and sensory median after treatment were 53.35±4.7 and 57.3±5.6 and motor and sensory ulnar After treatment were 54.56±2.99 and 54.09±12.17. The result of the study. Shows that there were reduction of conduction velocity before treatment and statistically significant after 3 months duration of treatment with appropriate doses. Conclusion: After treatment, total triiodothyronine, total thyroxin, free triiodothyronine, free thyroxin, thyroid-stimulating hormone, and median and ulnar nerve motor and sensory functions were normal with appropriate treatment. The involvement of sensory fibers is more than that of the motor fibers.


Author(s):  
Riccardo Marvulli ◽  
Giancarlo Ianieri ◽  
Grazia Devenuto ◽  
Marta Falcicchio ◽  
Giulia A. Gallo ◽  
...  

Background and Objective: Carpal tunnel syndrome (CTS) is the most common form of nerve entrapment. Clinically, various signs and symptoms compare due to overexposure to mechanical vibrations transmitted to the wrist bones and cartilage, resulting in compression of the sensory and motor nerve fibers of median nerve. Early symptoms include nocturnal paresthesia and electromyography reveals reduced sensory nerve conduction velocity. Aim of this study was to evaluate the efficacy of a dietary integrator composed of acetyl-L-carnitine, α-lipoic acid,quercetin, bromelain, pantothenic acid, C and B1 and B2 and B6 and B12 vitamins in patients with early (minimal) carpal tunnel syndrome. Methods: 36 patients (28 female and 8 male) with early CTS characterized by sensory nerve demyelination and inflammation of the transverse carpal ligament. Patients were divided into two groups, group A (18 patients received physical therapy) and group B (18 patients, received physical therapy and an oral integrator). Clinical (sleep quality questionnaire to measure severity of paresthesia) and neurophysiological assessment (Sensory Nerve Conduction Velocity) performed at baseline, and then at 30 and 60 days after treatment. Results: Sleep quality and Sensory Nerve Conduction Velocity data analysis show improvement in both groups at 30 and 60 days, with statistically difference between them in both time of analysis. Conclusions: In the early CTS, with sensory fibers damage, use of dietary integrator, such as Micronil Dol®, composed composed of acetyl-L-carnitine, α-lipoic acid,quercetin, bromelain, pantothenic acid, C and B1 and B2 and B6 and B12 vitamins can be effective in quick recovery of median nerve sensory.


2021 ◽  
Vol 9 (1) ◽  
pp. e001698
Author(s):  
Haifa Maalmi ◽  
Kristiaan Wouters ◽  
Hans H C M Savelberg ◽  
Jeroen H P M van der Velde ◽  
Jos P H Reulen ◽  
...  

IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.


1999 ◽  
Vol 129 (1) ◽  
pp. 207-213 ◽  
Author(s):  
Alain Gerbi ◽  
Jean-Michel Maixent ◽  
Jean-Luc Ansaldi ◽  
Michele Pierlovisi ◽  
Thierry Coste ◽  
...  

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