The association of serum uric acid with total white blood cell count in a healthy Indian adult population

Author(s):  
Sathya Selvarajan ◽  
R Jothimalar ◽  
Santhi Silambanan
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
David R. Mack ◽  
Bradley Saul ◽  
Brendan Boyle ◽  
Anne Griffiths ◽  
Cary Sauer ◽  
...  

2002 ◽  
Vol 26 (6) ◽  
pp. 805-813 ◽  
Author(s):  
TS Church ◽  
CE Finley ◽  
CP Earnest ◽  
JB Kampert ◽  
LW Gibbons ◽  
...  

2021 ◽  
Vol 2 (2) ◽  
pp. 55-62
Author(s):  
P. A. Obazelu ◽  
I. A. Aruomaren ◽  
C. C. Nwangwu

Saccharomyces boulardii is a probiotic yeast used as a nutritional supplement. Co-trimoxazole, is a broad-spectrum antimicrobial agent used in the prophylaxis and treatment of infections.The goal of this study was to evaluate the individual and interactive effects of probiotic Saccharomyces boulardii and co-trimoxazole on some haematological parameters in albino rats. Thirty (30) albino Wistar rats weighing 150-200g were divided into five groups; Basal, A, B, C, and D, with six animals in each group. Group A (control) was given a normal rat pellet (standardized feed) and clean water (pH 6.5- 8.5). Group B was administered 5.5mg/kg body weight of the commercial probiotics (Saccharomyces boulardii). Group C was administered 4.4mg/kg body weight of co-trimoxazole. Group D was administered 5.5mg/kg body weight of the commercial probiotics and 4.4mg/kg body weight of co-trimoxazole. All administrations were done using a gavage tube for 15 days. Blood samples were collected for analysis on days 0, 5 and 15. The results showed that Saccharomyces boulardii caused a significant increase (P<0.05) in total white blood cell count and packed cell volume of the treated groups at day 5. On day 15, the total white blood cell count (10.67±0.66), packed cell volume (43.23±0.47), platelet count (932±38.89) and mean platelet volume (8.53±0.38) showed a significant increase (P<0.05) in the probiotic group. The co-trimoxazole group showed a significant reduction (P<0.05) in the packed cell volume and total white blood cell count. This study shows that Saccharomyces boulardii has a positive effect on the haematological profile of the test animals.


2016 ◽  
Vol 46 ◽  
pp. 259-264 ◽  
Author(s):  
Görkem KARAKAŞ UĞURLU ◽  
Semra ULUSOY KAYMAK ◽  
Mustafa UĞURLU ◽  
Sibel ÖRSEL ◽  
Ali ÇAYKÖYLÜ

Stroke ◽  
2020 ◽  
Vol 51 (7) ◽  
pp. 2103-2110
Author(s):  
Tim Y. Cras ◽  
Daniel Bos ◽  
M. Arfan Ikram ◽  
Mervyn D.I. Vergouwen ◽  
Diederik W.J. Dippel ◽  
...  

Background and Purpose: The prevalence of unruptured intracranial aneurysms (UIAs) in the adult population is ≈3%. Rupture of an intracranial aneurysm can have devastating consequences, which emphasizes the importance of identification of potentially modifiable determinants for the presence and size of UIAs. Our aim was to study the association of a broad spectrum of potential determinants with the presence and size of UIAs in a general adult population. Methods: Between 2005 and 2015, 5841 participants from the population-based Rotterdam Study (mean age, 64.4 years, 45.0% male) underwent brain magnetic resonance imaging (1.5T). These scans were evaluated for the presence of incidental UIAs. We determined number and volume of the UIAs. Using logistic and linear regression models, we assessed the association of cardiovascular, lifestyle and emerging inflammatory and hormonal determinants with the presence and volume of UIAs. Results: In 134 (2.3%) participants, ≥1 UIAs were detected (149 UIAs in total), with a median volume of 61.1 mm 3 (interquartile range, 33.2–134.0). In multivariable models, female sex (odds ratio, 1.92 [95% CI, 1.33–2.84]), hypertension (odds ratio, 1.73 [95% CI, 1.13–2.68]), and current smoking (odds ratio, 3.75 [95% CI, 2.27–6.33]) were associated with the presence of UIAs. We found no association of alcohol use, physical activity, or diet quality with UIA presence. Finally, we found white blood cell count to relate to larger aneurysm volume (difference in volume of 33.6 mm 3 per 10 9 /L increase in white blood cell [95% CI, 3.92–63.5]). Conclusions: In this population-based study, female sex, hypertension, and smoking, but no other lifestyle determinants, were associated with the presence of UIAs. White blood cell count is associated with size of UIAs. Preventive strategies should focus on treating hypertension and promoting cessation of smoking.


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