scholarly journals Biological Effects of Low Dose Radiation and Adaptive Responses in Mammalian Cells(The 29th Autumn Scientific Congress)

2002 ◽  
Vol 58 (10) ◽  
pp. 1328-1334 ◽  
Author(s):  
Shuji Yonei ◽  
Qiu-Mei Zhang
Keyword(s):  
Mammalian Cells ◽  
Low Dose ◽  
Biological Effects ◽  
Adaptive Responses ◽  
Low Dose Radiation ◽  
Scientific Congress ◽  
Dose Radiation

scholarly journals The Adaptive Responses in Non-Small Cell Lung Cancer A549 Cell Lines Induced by Low-Dose Ionizing Radiation and the Variations of miRNA Expression

Dose-Response ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 155932582110399
Author(s):  
Xiao-Chun Wang ◽  
Li-Li Tian ◽  
Cai-Xia Fan ◽  
Cai-Hong Duo ◽  
Ke-Ming Xu
Keyword(s):  
Mirna Expression ◽  
Low Dose ◽  
Target Genes ◽  
Biological Effects ◽  
Cell Communication ◽  
A549 Cells ◽  
Enrichment Analysis ◽  
Adaptive Responses ◽  
Low Dose Radiation ◽  
Dose Radiation

Objective To study the effects of adaptive response in A549 cells induced by low-dose radiation and the miRNAs expression. Methods A549 cells were irradiated with 50 mGy and 200 mGy initial doses, respectively, and then irradiated with a challenge dose 20 Gy at 6 hours interval. The biological effects and miRNA expression were detected. Results The apoptosis rates of 50 mGy-20 Gy and 200 mGy-20 Gy groups were significantly lower than that of only 20 Gy irradiation group ( P < .05). The percentage of G2/M phase cells of 50 mGy-20 Gy and 200 mGy-20 Gy groups was significantly decreased relative to the 20 Gy group ( P < .05). One miRNA (mir-3662) was upregulated and 15 miRNAs (mir-185, mir-1908, mir-307, mir-182, mir-92a, mir-582, mi-r501, mir138-5p, mir-1260, mir-484, mir-378d, mir-193b, mir-127-3p, mir-1303, and mir-654-5p) were downregulated both in 50 mGy-20 Gy and 200 mGy-20 Gy groups than that of the 20 Gy group. Go and KEGG enrichment analysis showed that the target genes were significantly enriched in cell communication regulation, metabolic process, enzyme binding, and catalytic activity signaling pathways. Conclusion Low-dose X-ray of 50 mGy and 200 mGy radiation can induce adaptive apoptosis response prior to 20 Gy in A549 cells. Sixteen differently expressed miRNAs may play important roles in the adaptive effect of low-dose radiation.

Reactive oxygen species in cell responses to toxic agents

2002 ◽  
Vol 21 (2) ◽  
pp. 85-90 ◽  
Author(s):  
L E Feinendegen
Keyword(s):  
Radiation Exposure ◽  
Mammalian Cells ◽  
Low Dose ◽  
X Rays ◽  
Low Dose Radiation ◽  
Cell Responses ◽  
Toxic Agents ◽  
Particle Tracks ◽  
Dose Radiation

This review first summarizes experimental data on biological effects of different concentrations of ROS in mammalian cells and on their potential role in modifying cell responses to toxic agents. It then attempts to link the role of steadily produced metabolic ROS at various concentrations in mammalian cells to that of environmentally derived ROS bursts from exposure to ionizing radiation. The ROS from both sources are known to both cause biological damage and change cellular signaling, depending on their concentration at a given time. At low concentrations signaling effects of ROS appear to protect cellular survival and dominate over damage, and the reverse occurs at high ROS concentrations. Background radiation generates suprabasal ROS bursts along charged particle tracks several times a year in each nanogram of tissue, i.e., average mass of a mammalian cell. For instance, a burst of about 200 ROS occurs within less than a microsecond from low-LET irradiation such as X-rays along the track of a Compton electron (about 6 keV, ranging about 1 μm). One such track per nanogram tissue gives about 1 mGy to this mass. The number of instantaneous ROS per burst along the track of a 4-meV ¬-particle in 1 ng tissue reaches some 70000. The sizes, types and sites of these bursts, and the time intervals between them directly in and around cells appear essential for understanding low-dose and low dose-rate effects on top of effects from endogenous ROS. At background and low-dose radiation exposure, a major role of ROS bursts along particle tracks focuses on ROS-induced apoptosis of damage-carrying cells, and also on prevention and removal of DNA damage from endogenous sources by way of temporarily protective, i.e., adaptive, cellular responses. A conclusion is to consider low-dose radiation exposure as a provider of physiological mechanisms for tissue homoeostasis.

Experimental studies on the biological effects of low-dose-rate and low-dose radiation

2008 ◽  
Vol 5 (1) ◽  
pp. 55 ◽  
Author(s):  
Yoichi Oghiso ◽  
Satoshi Tanaka ◽  
Ignacia B. Tanaka III ◽  
Fumiaki Sato
Keyword(s):  
Dose Rate ◽  
Low Dose ◽  
Biological Effects ◽  
Experimental Studies ◽  
Low Dose Radiation ◽  
Low Dose Rate ◽  
Dose Radiation

scholarly journals Adaptive Responses Induced by Low Dose Radiation in Dentate Gyrus of Rats

2006 ◽  
Vol 21 (6) ◽  
pp. 1103 ◽  
Author(s):  
Jin Oh Kang ◽  
Seong Eon Hong ◽  
Sang Ki Kim ◽  
Chang Ju Kim ◽  
Taeck Hyun Lee ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Low Dose ◽  
Adaptive Responses ◽  
Low Dose Radiation ◽  
Dose Radiation

scholarly journals Research Progress on the Biological Effects of Low-Dose Radiation in China

Dose-Response ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 155932581983348 ◽  
Author(s):  
Kaihua Ji ◽  
Yan Wang ◽  
Liqing Du ◽  
Chang Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Low Dose ◽  
Biological Effects ◽  
Research Progress ◽  
Low Dose Radiation ◽  
Dose Radiation

scholarly journals X-Ray Hesitancy: Patients’ Radiophobic Concerns Over Medical X-rays

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582095954 ◽  
Author(s):  
Paul A. Oakley ◽  
Deed E. Harrison
Keyword(s):  
Low Dose ◽  
Background Radiation ◽  
X Rays ◽  
Adaptive Responses ◽  
Low Dose Radiation ◽  
X Ray ◽  
X Ray Imaging ◽  
The Family ◽  
Diagnostic Radiation ◽  
Dose Radiation

All too often the family physician, orthopedic surgeon, dentist or chiropractor is met with radiophobic concerns about X-ray imaging in the clinical setting. These concerns, however, are unwarranted fears based on common but ill-informed and perpetuated ideology versus current understanding of the effects of low-dose radiation exposures. Themes of X-ray hesitancy come in 3 forms: 1. All radiation exposures are harmful (i.e. carcinogenic); 2. Radiation exposures are cumulative; 3. Children are more susceptible to radiation. Herein we address these concerns and find that low-dose radiation activates the body’s adaptive responses and leads to reduced cancers. Low-dose radiation is not cumulative as long as enough time (e.g. 24 hrs) passes prior to a repeated exposure, and any damage is repaired, removed, or eliminated. Children have more active immune systems; the literature shows children are no more affected than adults by radiation exposures. Medical X-rays present a small, insignificant addition to background radiation exposure that is not likely to cause harm. Doctors and patients alike should be better informed of the lack of risks from diagnostic radiation and the decision to image should rely on the best evidence, unique needs of the patient, and the expertise of the physician—not radiophobia.

Biological effects of low-dose radiation from a TV set on embryos and chicks

1994 ◽  
Vol 83 (02) ◽  
pp. 87-87
Author(s):  
B.J. Boudard ◽  
B.J. Youbicier-Simo ◽  
J.D. Baylé ◽  
M. Bastide
Keyword(s):  
Low Dose ◽  
Biological Effects ◽  
Low Dose Radiation ◽  
Dose Radiation
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