Early Detection of Renal Cell Carcinoma by Ultrasonic Mass Survey

134 Background: Although sunitinib is effective first-line therapy (1LT) for metastatic renal cell carcinoma (mRCC), ~20% of patients experience rapid progressive disease (PD). Traditional RECIST monitoring often does not detect PD until 90 days after 1LT initiation. Investigational angiogenesis-specific imaging (AI) may identify PD as early as 14 days post-1LT initiation, thus allowing a switch to a potentially more effective second-line therapy and avoiding unnecessary risk of AEs. This study’s goal was to quantify the potential reduction in futile 1LT length, AEs, and costs by using AI for early detection of PD. Methods: Decision modeling with a 90-day horizon evaluated a comparator arm using RECIST monitoring at 90 days and an intervention arm using AI at 14 days. Sunitinib costs were $21,250 for the comparator arm and $13,282 for the intervention arm. RECIST costs were $619 and AI costs were tested as a breakeven analysis. A literature review quantified AE rates associated with 1LT sunitinib and claims data were used to determine costs. Early PD detection was estimated based on a 20% rapid PD rate. Results: For AI sensitivity of 50% to predict rapid PD, a 38-day reduction in futile 1LT could be achieved per PD patient by using AI vs. RECIST (AI sensitivity of 75%/100% yielded 57/76 fewer days). The potential number of AEs avoided through early PD identification is shown below. Costs saved per 1,000 mRCC patients were $684,566 for AEs and $3,187,400 for futile 1LT. Based on these results, $3,872 per mRCC patient would be freed up for AI. Conclusions: Continuing 1LT after PD brings unnecessary risk of AEs and delays potentially effective 2nd-line therapy. Results of this study indicate that early PD identification using AI may improve quality of care by minimizing duration of futile 1LT and avoiding unnecessary AEs. [Table: see text]

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The Value of Whole Lung Tomography in the Early Detection of Metastatic Disease in Patients with Renal Cell Carcinoma and Testicular Tumors

The Journal of Urology ◽

10.1016/s0022-5347(17)55702-x ◽

1980 ◽

Vol 124 (6) ◽

pp. 860-862 ◽

Cited By ~ 9

Author(s):

Stuart M. Bergman ◽

Marguerite Lippert ◽

Nasser Javadpour

Keyword(s):

Renal Cell Carcinoma ◽

Early Detection ◽

Cell Carcinoma ◽

Metastatic Disease ◽

Renal Cell ◽

Testicular Tumors

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Early-onset renal cell carcinoma in PTEN harmatoma tumour syndrome

npj Genomic Medicine ◽

10.1038/s41525-020-00148-7 ◽

2020 ◽

Vol 5 (1) ◽

Cited By ~ 1

Author(s):

Raymond H. Kim ◽

Xiangling Wang ◽

Andrew J. Evans ◽

Steven C. Campbell ◽

Jane K. Nguyen ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Early Detection ◽

Cell Carcinoma ◽

Kidney Cancer ◽

Renal Cell ◽

Cowden Syndrome ◽

Elevated Risk ◽

Renal Ultrasound ◽

Increased Risk ◽

Risk Of Cancer

Abstract Individuals with PTEN hamartoma tumour syndrome (PHTS), including Cowden syndrome (CS), are susceptible to multiple benign hamartomas and an increased risk of cancer, particularly breast, endometrial, and thyroid. As a result, individuals undergo enhanced surveillance for early detection of these cancers. However, less commonly occurring cancers, such as colorectal and kidney, have insufficient guidelines for early detection. Currently, screening for kidney cancer via renal ultrasound begins at 40 years of age, because there were only rare cases of elevated risk in prospective series under 40. There have, however, been accumulating reports of kidney cancer in individuals with CS in their 30s, illustrating a need to lower the age of surveillance. We present additional evidence of renal cell carcinoma in two individuals with CS in their early twenties, and propose a reassessment of the abdominal surveillance in patients with PHTS. We propose biannual screening for kidney cancer beginning at 20 years of age.

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