scholarly journals The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction

2018 ◽  
Vol 14 (13) ◽  
pp. 1845-1858 ◽  
Author(s):  
Bin He ◽  
Longfei Dai ◽  
Xiaoqian Zhang ◽  
Diyu Chen ◽  
Jingbang Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hdac Inhibitor ◽  
G1 Phase ◽  
Apoptosis Induction ◽  
Phase Arrest ◽  
G1 Phase Arrest

scholarly journals Astragaloside IV Induces Apoptosis, G1-Phase Arrest and Inhibits Anti-apoptotic Signaling in Hepatocellular Carcinoma

In Vivo ◽  
2020 ◽  
Vol 34 (2) ◽  
pp. 631-638
Author(s):  
CHUN-MIN SU ◽  
HSIAO-CHIA WANG ◽  
FEI-TING HSU ◽  
CHUN-HUI LU ◽  
CHIEN-KAI LAI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
G1 Phase ◽  
Astragaloside Iv ◽  
Apoptotic Signaling ◽  
Phase Arrest ◽  
G1 Phase Arrest

scholarly journals Knockdown of CENPW Inhibits Hepatocellular Carcinoma Progression by Inactivating E2F Signaling

2021 ◽  
Vol 20 ◽  
pp. 153303382110072
Author(s):  
Yajing Zhou ◽  
Hua Chai ◽  
Lei Guo ◽  
Zhongqiu Dai ◽  
Jianming Lai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
G1 Phase ◽  
Migration And Invasion ◽  
Cell Cycle Distribution ◽  
Colony Formation Assay ◽  
Transwell Assay ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Hcc Cells

Aim: This study aimed to evaluate the effects of centromere protein W (CENPW, also known as CUG2) in hepatocellular carcinoma (HCC). Methods: CENPW expression in HCC tissues and cells was detected by RT-qPCR assay. CCK-8 and colony formation assay were used to assess cell proliferation. Wound healing and Transwell assay was used to detect cell migration and invasion, respectively. The flow cytometry was used to analyze the cell cycle distribution and apoptosis. Results: CENPW expression was upregulated in HCC tissues and cells. Knockdown of CENPW inhibited cell proliferation, migration, and invasion and induced the G0/G1 phase arrest and cell apoptosis in HCC cells, which might involve the E2F signaling regulation. Conclusion: CENPW acted as an oncogenic role in HCC progression via activation E2F signaling. Our findings may provide new insights into the studying mechanisms of HCC.

scholarly journals Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro

2016 ◽  
Vol 37 (7) ◽  
pp. 950-962 ◽  
Author(s):  
Jing-bo Yang ◽  
Muhammad Khan ◽  
Yang-yang He ◽  
Min Yao ◽  
Yong-ming Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prostate Carcinoma ◽  
Carcinoma Cells ◽  
Human Prostate ◽  
G1 Phase ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Human Prostate Carcinoma

scholarly journals Overexpression of USF Increases TGF-β1 Protein Levels, But G1 Phase Arrest was not Induced in FRTL-5 Cells

2008 ◽  
Vol 23 (5) ◽  
pp. 870 ◽  
Author(s):  
Keun-Sook Kim ◽  
Hye Seung Jung ◽  
Yun Jae Chung ◽  
Tae Sik Jung ◽  
Hye Won Jang ◽  
...  
Keyword(s):  
G1 Phase ◽  
Protein Levels ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Tgf Β1
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