Alcohol Consumption and Lung Cancer According to Ile349Val Polymorphism in ADH3 Gene: Beyond the Tobacco Smoking Effect

Abstract Background Lung cancer is the second most common cancer worldwide and the leading cause of death for cancer (18.4%). During the last 30 years, lung cancer incidence and mortality increased in women and decreased in men, because of tobacco smoking exposure. Population survival trend reflects both the influence of disease severity at diagnosis and treatment effectiveness. Some studies reported an increase in global lung cancer survival and linked it to new treatment options. However, change in the overall survival may also reflect a shift towards morphologies with more favorable prognosis. We analyzed overall and morphology specific survival trends for lung cancer to gain insight on the role of new treatments and changing exposures. Methods We analyzed lung cancer 1 y-survival and 3 y-survival after diagnosis in Umbria (890'000 inhabitants) in the period 1994-2016. Population-based data were obtained from the Umbrian Cancer Registry (RTUP), Italy. We estimated relative net survival (Pohar-Perme approach) stratified both for sex and histotype (NSCLC, SCLC, NOS), considering six diagnostic periods from 1994 to 2016 (4 years for period, except 3 in the last one) for 5'268 lung cancer cases (26% women). Results Overall survival by gender resulted 40,5% (1y) and 16.5% (3y) in men, 47,3% (1y) and 23,2% (3y) in women. NSCLC survival increased in women during the period 1994-2016 from 41% to 53% (1y) and from 23% to 33% (3y), and remained unchanged in men. SCLC 3 year-survival did not change significantly neither in women nor in men. Conclusions We did not observe a significant increase in lung cancer survival over a 25 years period. We observed a significant increase in survival probabilities for NSCLC among women only. Thus, our data don't confirm a major role of new treatments in improving lung cancer control. We will provide further analyses for adenocarcinoma and a comparison of incidence and mortality trends to understand the influence of exposures and treatments on survival. Key messages A general increase in lung cancer survival, as could be expected after the introduction of new highly effective treatments is not present in western countries. Reducing exposure to tobacco smoking and environmental pollution remain the main intervention to improve lung cancer control.

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Sex and gender differences in tobacco smoking among adolescents in French secondary schools

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2008.393 ◽

2016 ◽

Vol 70 (3) ◽

Cited By ~ 1

Author(s):

S. Kalaboka ◽

J.P. Piau ◽

G. King ◽

D. Moreau ◽

M. Choquet ◽

...

Keyword(s):

Public Schools ◽

Alcohol Consumption ◽

Tobacco Smoking ◽

Protective Factor ◽

Smoking Behaviour ◽

Influential Factors ◽

Sex And Gender ◽

Regular Smoker ◽

Occasional Smoker ◽

And Gender

Aim. We investigated the relationship between sex (genetic/biological) and gender (environmental/ cultural) factors in relation to adolescent tobacco smoking. Methods. A representative sample of 11,582 students from French secondary public schools participated in the study by completing a self-administered, standardised questionnaire. Results. Using the WHO classification for smoking in the youth, 15.6% of the adolescents were regular smokers, 7.7% occasional smokers, 17.9% experimental smokers and 4.8% ex-smokers, with no statistically significant gender difference. Taking non-smoking as a reference, puberty had a much greater effect on the likelihood of being a regular smoker [OR=18.0 (95% Confidence Interval: 9.6- 32)] than of being an experimental/occasional smoker [OR=3.7 (2.9-4.6)] among girls. For boys, the effect of puberty was not as great [OR=4.7 (3.5-6.5)] for regular vs. [OR=2.1 (1.8-2.5)] for experimental/occasional smokers). Similarly, illicit drug use had a larger effect on the likelihood of being regular smoker vs. non-smoker [OR=15.0 (12.0-20.0) in boys and 12 (8.8-16.0) in girls] than of being experimental/occasional smoker vs. a non-smoker [OR=4.8 (3.7-6.1) and 2.9 (2.1-3.9) respectively]. Other factors related to regular smoking were exposure to passive smoking and regular alcohol consumption. Living with both parents was a protective factor for life and regular smoking in both genders. Conclusions. Our results show that influential factors of sex-related (puberty), gender-specific (environmental tobacco smoking, alcohol consumption, drug abuse) or sex/gender (regular sexual intercourse) are related to the smoking behaviour in French adolescents.

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TU87. A GENETICALLY-INFORMED EVALUATION OF THE RELATIONSHIPS BETWEEN TOBACCO SMOKING, CANNABIS USE, ALCOHOL CONSUMPTION, AND RESPIRATORY INFECTIONS, INCLUDING COVID-19

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2021.08.088 ◽

2021 ◽

Vol 51 ◽

pp. e143

Author(s):

Joyce Yoo ◽

Daniel Rosoff ◽

Falk Lohoff

Keyword(s):

Alcohol Consumption ◽

Tobacco Smoking ◽

Respiratory Infections ◽

Cannabis Use

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Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies

American Journal of Clinical Nutrition ◽

10.1093/ajcn/82.3.657 ◽

2005 ◽

Vol 82 (3) ◽

pp. 657-667 ◽

Cited By ~ 69

Author(s):

Jo L Freudenheim ◽

John Ritz ◽

Stephanie A Smith-Warner ◽

Demetrius Albanes ◽

Elisa V Bandera ◽

...

Keyword(s):

Lung Cancer ◽

Alcohol Consumption ◽

Cohort Studies ◽

Pooled Analysis

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Survival in operable non-small-cell lung cancer: Role of p53 mutations, tobacco smoking and asbestos exposure

International Journal of Cancer ◽

10.1002/(sici)1097-0215(20000515)86:4<590::aid-ijc23>3.0.co;2-e ◽

2000 ◽

Vol 86 (4) ◽

pp. 590-594 ◽

Cited By ~ 25

Author(s):

Thanos Sioris ◽

Kirsti Husgafvel-Pursiainen ◽

Antti Karjalainen ◽

Sisko Anttila ◽

Annamaria Kannio ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Tobacco Smoking ◽

Asbestos Exposure ◽

Small Cell ◽

P53 Mutations ◽

Small Cell Lung

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TOBACCO SMOKING AND LUNG CANCER

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1959.tb89297.x ◽

1959 ◽

Vol 2 (2) ◽

pp. 60-60

Keyword(s):

Lung Cancer ◽

Tobacco Smoking

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Tobacco Smoking: Risk to Develop Addiction, Chronic Obstructive Pulmonary Disease, and Lung Cancer

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892814666190102122848 ◽

2019 ◽

Vol 14 (1) ◽

pp. 39-52 ◽

Cited By ~ 6

Author(s):

Alessia Santoro ◽

Carlo Tomino ◽

Giulia Prinzi ◽

Palma Lamonaca ◽

Vittorio Cardaci ◽

...

Keyword(s):

Lung Cancer ◽

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Tobacco Smoking ◽

Nicotinic Receptors ◽

Bronchial Epithelial Cells ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Bronchial Epithelial

Background: The morbidity and mortality associated with tobacco smoking is well established. Nicotine is the addictive component of tobacco. Nicotine, through the non-neuronal α7nicotinic receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits drug-induced apoptosis. Objective: To understand the genetic, molecular and cellular biology of addiction, chronic obstructive pulmonary disease and lung cancer. Methods: The search for papers to be included in the review was performed during the months of July- September 2018 in the following databases: PubMed (http://www.ncbi.nlm.nih.gov), Scopus (http://www.scopus.com), EMBASE (http://www.elsevier.com/online-tools/embase), and ISI Web of Knowledge (http://apps.webofknowledge.com/). The following searching terms: “nicotine”, “nicotinic receptor”, and “addiction” or “COPD” or “lung cancer” were used. </P><P> Patents were retrieved in clinicaltrials.gov (https://clinicaltrials.gov/). All papers written in English were evaluated. The reference list of retrieved articles was also reviewed to identify other eligible studies that were not indexed by the above-mentioned databases. </P><P> New experimental data on the ability of nicotine to promote transformation of human bronchial epithelial cells, exposed for one hour to Benzo[a]pyrene-7,8-diol-9-10-epoxide, are reported. Results: Nicotinic receptors variants and nicotinic receptors upregulation are involved in addiction, chronic obstructive pulmonary disease and/or lung cancer. Nicotine through α7nicotinic receptor upregulation induces complete bronchial epithelial cells transformation. Conclusion: Genetic studies highlight the involvement of nicotinic receptors variants in addiction, chronic obstructive pulmonary disease and/or lung cancer. A future important step will be to translate these genetic findings to clinical practice. Interventions able to help smoking cessation in nicotine dependence subjects, under patent, are reported.

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