scholarly journals Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma

2019 ◽  
Vol 10 (21) ◽  
pp. 5124-5129 ◽  
Author(s):  
Donat Peter Sarlos ◽  
Maria V Yusenko ◽  
Lehel Peterfi ◽  
Arpad Szanto ◽  
Gyula Kovacs
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Dual Role ◽  
Cell Tumor ◽  
Conventional Renal Cell Carcinoma

Dual role of G-quadruplex in translocation renal cell carcinoma: Exploring plausible Cancer therapeutic innovation

2020 ◽  
Vol 1864 (12) ◽  
pp. 129719
Author(s):  
Neha ◽  
Parimal Das ◽  
Shiv Prakash Verma
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Dual Role ◽  
G Quadruplex

1255: Potential Role of Postoperative Azotemia in Predicting Response to Interleukin-2 (IL-2) Immunotherapy Following Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 414-414
Author(s):  
John S. Lam ◽  
Rakhee H. Gael ◽  
Tobias Klatte ◽  
Fairooz F. Kabbinavar ◽  
Arie S. Belldegrun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Interleukin 2 ◽  
Cytoreductive Nephrectomy

1111: External Validation of the Mayo Clinic SSIGN Score to Predict Cancer-Specific Survival Using a European Series of Conventional Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 357-358
Author(s):  
Vincenzo Ficarra ◽  
Christine M. Lohse ◽  
Giacomo Novara ◽  
Antonio Galfano ◽  
Stefano Cavalleri ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mayo Clinic ◽  
Renal Cell ◽  
External Validation ◽  
Cancer Specific Survival ◽  
Conventional Renal Cell Carcinoma

743: Resection of Nodal Disease in Patients with Metastatic Conventional Renal Cell Carcinoma Improves Survival

2006 ◽  
Vol 175 (4S) ◽  
pp. 241-242 ◽  
Author(s):  
Stephen Brassell ◽  
Ricardo F. Sanchez-Ortiz ◽  
Surena F. Matin ◽  
David A. Swanson ◽  
Christopher G. Wood
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Nodal Disease ◽  
Conventional Renal Cell Carcinoma

Role of the UPS in Renal Cell Carcinoma

2007 ◽  
Author(s):  
Paul Corn
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell

TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Proliferation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Lymphatic Invasion ◽  
Cancer Specific Survival ◽  
Candidate Target ◽  
Candidate Target Gene ◽  
And Migration

TRIM44 has oncogenic roles in various cancers. However, TRIM44 expression andits function in renal cell carcinoma (RCC) are still unknown. Here in this study, weinvestigated the clinical significance of TRIM44 and its biological function in RCC.TRIM44 overexpression was significantly associated with clinical M stage, histologictype (clear cell) and presence of lymphatic invasion (P = .047, P = .005, and P = .028,respectively). Moreover, TRIM44 overexpression was significantly associated withpoor prognosis in terms of cancer-specific survival (P = .019). Gain-of-function andloss-of-function studies using TRIM44 and siTRIM44 transfection showed thatTRIM44 promotes cell proliferation and cell migration in two RCC cell lines, Caki1and 769P. To further investigate the role of TRIM44 in RCC, we performed integratedmicroarray analysis in Caki1 and 769P cells and explored the data in the Oncominedatabase. Interestingly, FRK was identified as a promising candidate target gene ofTRIM44, which was downregulated in RCC compared with normal renal tissues. Wefound that cell proliferation was inhibited by TRIM44 knockdown and then recoveredby siFRK treatment. Taken together, the present study revealed the associationbetween high expression of TRIM44 and poor prognosis in

Beyond Promoter: The Role of Macrophage in Invasion and Progression of Renal Cell Carcinoma

2020 ◽  
Vol 15 (7) ◽  
pp. 588-596
Author(s):  
Haibao Zhang ◽  
Guodong Zhu
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Formation ◽  
Biological Behavior ◽  
Tumor Stem Cell ◽  
The Past ◽  
The Common

Renal cell carcinoma (RCC) is one of the common urologic neoplasms, and its incidence has been increasing over the past several decades; however, its pathogenesis is still unknown up to now. Recent studies have found that in addition to tumor cells, other cells in the tumor microenvironment also affect the biological behavior of the tumor. Among them, macrophages exist in a large amount in tumor microenvironment, and they are generally considered to play a key role in promoting tumorigenesis. Therefore, we summarized the recent researches on macrophage in the invasiveness and progression of RCC in latest years, and we also introduced and discussed many studies about macrophage in RCC to promote angiogenesis by changing tumor microenvironment and inhibit immune response in order to activate tumor progression. Moreover, macrophage interactes with various cytokines to promote tumor proliferation, invasion and metastasis, and it also promotes tumor stem cell formation and induces drug resistance in the progression of RCC. The highlight of this review is to make a summary of the roles of macrophage in the invasion and progression of RCC; at the same time to raise some potential and possible targets for future RCC therapy.

KIBRA plays as tumour suppressor via phosphorylation of LATS-2 in conventional renal cell carcinoma tissues

2021 ◽  
Vol 79 ◽  
pp. S752
Author(s):  
K. Mitsunari ◽  
Y. Miyata ◽  
T. Matsuo ◽  
K. Ohba ◽  
Y. Mukae ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumour Suppressor ◽  
Conventional Renal Cell Carcinoma

No role of adjuvant systemic therapy after complete metastasectomy in metastatic renal cell carcinoma?

2007 ◽  
Vol 25 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Cheol Kwak ◽  
Yong Hyun Park ◽  
Chang Wook Jeong ◽  
Sang Eun Lee ◽  
Ja Hyeon Ku
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Systemic Therapy ◽  
Renal Cell ◽  
Adjuvant Systemic Therapy
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