scholarly journals Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer

2022 ◽  
Vol 13 (2) ◽  
pp. 706-714
Author(s):  
Yixi Su ◽  
Qiang Huang ◽  
Li Lu ◽  
Hu Qu ◽  
Dejuan Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Promoter Methylation ◽  
Human Prostate ◽  
Human Prostate Cancer

MP61-10 SILENCING OF PMEPA1 IS ASSOCIATED WITH ACTIVATION OF AR SIGNALING IN HUMAN PROSTATE CANCER AND CASTRATION RESISTANT TUMOR GROWTH IN NUDE MOUSE

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Hua Li ◽  
Elizabeth Umeda ◽  
Yingjie Song ◽  
Denise Young ◽  
Lakshmi Ravindranath ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Nude Mouse ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Castration Resistant

SUPPRESSION OF PRIMARY TUMOR GROWTH AND THE PROGRESSION TO METASTASIS WITH p53 ADENOVIRUS IN HUMAN PROSTATE CANCER

2000 ◽  
Vol 164 (3 Part 1) ◽  
pp. 814-819 ◽  
Author(s):  
JAMES A. EASTHAM ◽  
WARREN GRAFTON ◽  
CINDY M. MARTIN ◽  
B. JILL WILLIAMS
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Primary Tumor Growth

A new mechanism of estrogen action in prostate cancer: Inhibition of tissue androgen production and prostate cancer growth by Estradiol in androgen independent prostate cancer xenografts

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15509-15509
Author(s):  
B. Montgomery ◽  
P. Nelson ◽  
D. L. Hess ◽  
R. Vessella ◽  
E. Corey
Keyword(s):  
Prostate Cancer ◽  
Estrogen Receptor ◽  
Tumor Growth ◽  
Receptor Antagonist ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Ici 182,780 ◽  
Estrogen Receptor Antagonist ◽  
Serum Androgens ◽  
Androgen Independent

15509 Background: Estrogens are effective agents in treating prostate cancer in patients in which serum androgens are already at ‘castrate‘ or anorchid levels. The mechanisms whereby estrogens inhibit ‘androgen-independent‘ prostate cancer are unclear. Methods: The androgen-independent human prostate cancer xenograft LuCaP 35V was implanted into orchiectomized male SCID mice and established tumors were treated with placebo pellets, 17β-estradiol (E2) slow-release pellets or E2 with the estrogen receptor antagonist ICI 182,780 as previously described (Clin Cancer Res 8:1003). Effects of E2 on tumor growth and tissue testosterone (T) and dihydrotestosterone (DHT) levels were evaluated by radioimmunoassay. Results: E2 significantly inhibited growth of androgen-independent LuCaP35V ( ∼35% inhibition at 4 weeks, p=0.0047, and increased survival of tumor bearing animals, (p trend =0.03) . The estrogen receptor antagonist ICI 182,780 did not block E2 inhibition of tumor growth, suggesting a receptor independent mechanism of tumor suppression. We then examined the effect of E2 on tissue T and DHT. E2 suppressed levels of tumor T and DHT in treated tumors. Tissue androgens in placebo treated LuCaP35V xenografts were; T=1.21 (± 0.18) pg/mg and DHT=3.54 (±1.07) pg/mg, and in E2-treated LuCaP35V T=0.23 (±0.09) pg/mg and DHT =0.44 (±0.14) pg/mg, (p<0.001). Levels of T and DHT in control liver tissue from both placebo and E2-treated animals were equivalent, at less than 0.2 pg/mg. Conclusions: We have shown that E2 inhibits growth of the androgen- independent human prostate cancer xenograft LuCaP35V, and that this inhibition is estrogen receptor independent. E2 significantly suppressed tumor tissue T and DHT suggesting a new mechanism of E2 mediated growth inhibition of androgen independent prostate cancer, potentially through inhibition of tumoral steroidogenesis. This model of ‘intracrine‘ tumor androgen production can be used to evaluate other inhibitors of tissue steroidogenesis. No significant financial relationships to disclose.

SUPPRESSION OF PRIMARY TUMOR GROWTH AND THE PROGRESSION TO METASTASIS WITH p53 ADENOVIRUS IN HUMAN PROSTATE CANCER

2000 ◽  
pp. 814-819 ◽  
Author(s):  
JAMES A. EASTHAM ◽  
WARREN GRAFTON ◽  
CINDY M. MARTIN ◽  
B. JILL WILLIAMS
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Primary Tumor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Primary Tumor Growth

scholarly journals Insensitivity to Transforming Growth Factor-β Results from Promoter Methylation of Cognate Receptors in Human Prostate Cancer Cells (LNCaP)

2005 ◽  
Vol 19 (9) ◽  
pp. 2390-2399 ◽  
Author(s):  
Qiang Zhang ◽  
Jonathan N. Rubenstein ◽  
Thomas L. Jang ◽  
Michael Pins ◽  
Borko Javonovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Promoter Methylation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation

2008 ◽  
Vol 270 (1) ◽  
pp. 132-143 ◽  
Author(s):  
Xiaoying Wang ◽  
Volodymyr Tryndyak ◽  
Eugene O. Apostolov ◽  
Xiaoyan Yin ◽  
Sudhir V. Shah ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Promoter Methylation ◽  
Human Prostate ◽  
Chemotherapeutic Drugs ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Suramin-Induced Decrease in Prostate-Specific Antigen Expression With No Effect on Tumor Growth in the LNCaP Model of Human Prostate Cancer

1996 ◽  
Vol 88 (12) ◽  
pp. 794-801 ◽  
Author(s):  
G. N. Thalmann ◽  
R. A. Sikes ◽  
S.-M. Chang ◽  
D. A. Johnston ◽  
A. C. von Eschenbach ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Antigen Expression ◽  
Human Prostate ◽  
Human Prostate Cancer

CCL2 INCREASES IN VIVO TUMOR GROWTH OF HUMAN PROSTATE CANCER PC-3 TUMOR XENOGRAFT

2009 ◽  
Vol 181 (4S) ◽  
pp. 264-264
Author(s):  
Kosuke Mizutani ◽  
Sudha Sud ◽  
Zachary Varsos ◽  
Hernan Roca ◽  
Kenneth J Pienta
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Human Prostate ◽  
Tumor Xenograft ◽  
Human Prostate Cancer

scholarly journals miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Mirjam Kiener ◽  
Lanpeng Chen ◽  
Markus Krebs ◽  
Joël Grosjean ◽  
Irena Klima ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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