scholarly journals Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway

Theranostics ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 9083-9099
Author(s):  
Hui-Juan Liu ◽  
Yuan Qin ◽  
Zi-Han Zhao ◽  
Yang Zhang ◽  
Jia-Huan Yang ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Selenium Nanoparticles ◽  
Target Tumor Cell

Folic Acid Immobilized Ferrimagnetic DP-Bioglass to Target Tumor Cell for Cancer Hyperthermia Treatment

2006 ◽  
pp. 50-57
Author(s):  
Min Hua Chen ◽  
Chung King Hsu ◽  
Feng Huei Lin ◽  
Leszek Stobinski ◽  
Jerzy Peszke
Keyword(s):  
Folic Acid ◽  
Tumor Cell ◽  
Hyperthermia Treatment ◽  
Target Tumor Cell ◽  
Cancer Hyperthermia

scholarly journals Ti (WT31)-negative, CD3-positive, large granular lymphocyte leukemia with nonspecific cytotoxicity

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 923-931 ◽  
Author(s):  
K Oshimi ◽  
S Hoshino ◽  
M Takahashi ◽  
M Akahoshi ◽  
H Saito ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Small Population ◽  
Large Granular Lymphocyte ◽  
Immunoglobulin Gene ◽  
Proliferating Cells ◽  
Killer Activity ◽  
Large Granular Lymphocyte Leukemia ◽  
Target Tumor Cell ◽  
Nonspecific Cytotoxicity

Abstract A case of WT31-, CD3+ large granular lymphocyte leukemia is reported. On surface marker analysis, the proliferating cells were found to be CD3+4–8–16+ and WT31-. By two-color immunofluorescence staining, CD3+4- 8- cells were found to be WT31-, and a small population of WT31+ cells expressed either CD4 or CD8. WT31-, CD3+ cells were also identified in a bulk culture of lymphocytes expanded in vitro. Because WT31 monoclonal antibody (MoAb) reacts with the nonpolymorphic epitope of the disulfide-linked heterodimer of the T cell antigen receptor (Ti), the absence of the WT31-reactive Ti determinant may represent an expression of different CD3-associated polypeptides. The rearrangement of the Ti-beta and Ti-gamma genes but not the immunoglobulin gene was demonstrated, and the single pattern of rearrangement indicated the monoclonal origin of the lymphocytes. When the lymphocytes were assayed for their cytotoxicity against K562, MOLT-4, Daudi, and Raji tumor cell lines, a broad spectrum of cytotoxicity for these tumor cells was observed, and the lymphocytes also exhibited antibody- and lectin- dependent cellular cytotoxicity and lymphokine-activated killer activity. Treatment with anti-CD2 and anti-CD3 MoAbs inhibited their nonspecific cytotoxicity. The anti-CD3-mediated inhibition of nonspecific cytotoxicity suggested that an as yet unidentified Ti, present in association with the CD3 molecule on these lymphocytes, serves as a specific receptor for target tumor cell recognition.

scholarly journals Ti (WT31)-negative, CD3-positive, large granular lymphocyte leukemia with nonspecific cytotoxicity

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 923-931
Author(s):  
K Oshimi ◽  
S Hoshino ◽  
M Takahashi ◽  
M Akahoshi ◽  
H Saito ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Small Population ◽  
Large Granular Lymphocyte ◽  
Immunoglobulin Gene ◽  
Proliferating Cells ◽  
Killer Activity ◽  
Large Granular Lymphocyte Leukemia ◽  
Target Tumor Cell ◽  
Nonspecific Cytotoxicity

A case of WT31-, CD3+ large granular lymphocyte leukemia is reported. On surface marker analysis, the proliferating cells were found to be CD3+4–8–16+ and WT31-. By two-color immunofluorescence staining, CD3+4- 8- cells were found to be WT31-, and a small population of WT31+ cells expressed either CD4 or CD8. WT31-, CD3+ cells were also identified in a bulk culture of lymphocytes expanded in vitro. Because WT31 monoclonal antibody (MoAb) reacts with the nonpolymorphic epitope of the disulfide-linked heterodimer of the T cell antigen receptor (Ti), the absence of the WT31-reactive Ti determinant may represent an expression of different CD3-associated polypeptides. The rearrangement of the Ti-beta and Ti-gamma genes but not the immunoglobulin gene was demonstrated, and the single pattern of rearrangement indicated the monoclonal origin of the lymphocytes. When the lymphocytes were assayed for their cytotoxicity against K562, MOLT-4, Daudi, and Raji tumor cell lines, a broad spectrum of cytotoxicity for these tumor cells was observed, and the lymphocytes also exhibited antibody- and lectin- dependent cellular cytotoxicity and lymphokine-activated killer activity. Treatment with anti-CD2 and anti-CD3 MoAbs inhibited their nonspecific cytotoxicity. The anti-CD3-mediated inhibition of nonspecific cytotoxicity suggested that an as yet unidentified Ti, present in association with the CD3 molecule on these lymphocytes, serves as a specific receptor for target tumor cell recognition.

Dendritic Cell Transfected with Secondary Lymphoid-Tissue Chemokine and/or Interleukin-2 Gene-Enhanced Cytotoxicity of T-Lymphocyte in Human Bladder Tumor Cell S In Vitro

2009 ◽  
pp. 1-1
Author(s):  
Yong-Gang Li ◽  
Zhi-Ping Wang ◽  
Jun-Qiang Tian ◽  
Bin-Qiang Tian ◽  
Ronald Rodrigues ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Tumor Cell ◽  
T Lymphocyte ◽  
Lymphoid Tissue ◽  
Bladder Tumor ◽  
Interleukin 2 ◽  
Human Bladder ◽  
Secondary Lymphoid Tissue

Expression of HIF-1a and VEGF in human pituitary tumors and rodent pituitary tumor cell lines under hypoxia-mimicking condition

2008 ◽  
Vol 116 (09) ◽  
Author(s):  
B Shan ◽  
C Onofri ◽  
M Theodoropoulou ◽  
E Arzt ◽  
GK Stalla ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Pituitary Tumor ◽  
Pituitary Tumors ◽  
Tumor Cell Lines ◽  
Human Pituitary ◽  
Pituitary Tumor Cell
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