scholarly journals Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies

Theranostics ◽  
2022 ◽  
Vol 12 (3) ◽  
pp. 1419-1439
Author(s):  
Guanyu Chen ◽  
Weirong Kang ◽  
Wanqiong Li ◽  
Shaomeng Chen ◽  
Yanfeng Gao
Keyword(s):  
Oral Delivery ◽  
Intestinal Cell ◽  
Cell Targeting ◽  
Peptide Drugs ◽  
Specific Formulation

Niosomes for oral delivery of peptide drugs

1992 ◽  
Vol 21 (1-3) ◽  
pp. 145-153 ◽  
Author(s):  
H. Yoshida ◽  
C.-M. Lehr ◽  
W. Kok ◽  
H.E. Junginger ◽  
J.C. Verhoef ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs

Design of Nanoparticles for Oral Delivery of Peptide Drugs

2018 ◽  
pp. 407-414
Author(s):  
Hideki Ichikawa
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs

scholarly journals Investigation Of Vitamin B12-Modified Amphiphilic Sodium Alginate Derivatives For Enhancing The Oral Delivery Efficacy Of Peptide Drugs

2019 ◽  
Vol Volume 14 ◽  
pp. 7743-7758 ◽  
Author(s):  
Lingli Long ◽  
Minghua Lai ◽  
Xuhong Mao ◽  
Jiahao Luo ◽  
Xin Yuan ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
Oral Delivery ◽  
Vitamin B ◽  
Peptide Drugs

scholarly journals Toward Oral Delivery of Biopharmaceuticals: An Assessment of the Gastrointestinal Stability of 17 Peptide Drugs

2015 ◽  
Vol 12 (3) ◽  
pp. 966-973 ◽  
Author(s):  
Jie Wang ◽  
Vipul Yadav ◽  
Alice L. Smart ◽  
Shinichiro Tajiri ◽  
Abdul W. Basit
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs

Oral Delivery of Peptide Drugs

BioDrugs ◽  
2005 ◽  
Vol 19 (3) ◽  
pp. 165-177 ◽  
Author(s):  
Josias H Hamman ◽  
Gill M Enslin ◽  
Awie F Kotz??
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs

scholarly journals Oral Delivery of Probiotics Expressing Dendritic Cell-Targeting Peptide Fused with Porcine Epidemic Diarrhea Virus COE Antigen: A Promising Vaccine Strategy against PEDV

Viruses ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 312 ◽  
Author(s):  
Xiaona Wang ◽  
Li Wang ◽  
Xuewei Huang ◽  
Sunting Ma ◽  
Meiling Yu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Porcine Epidemic Diarrhea Virus ◽  
Oral Delivery ◽  
Cell Targeting ◽  
Vaccine Strategy ◽  
Diarrhea Virus ◽  
Porcine Epidemic Diarrhea ◽  
Antigen A ◽  
Targeting Peptide

scholarly journals Towards the Development of Orally Available Peptide Therapeutics

2021 ◽  
Vol 75 (6) ◽  
pp. 514-517
Author(s):  
Xu-Dong Kong ◽  
Christian Heinis
Keyword(s):  
Drug Development ◽  
Oral Administration ◽  
Oral Delivery ◽  
Cyclic Peptides ◽  
Large Majority ◽  
Peptide Drugs ◽  
Intestinal Uptake ◽  
Metabolic Products ◽  
Oral Availability ◽  
Flexible Application

Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic metabolic products. However, a major limitation of peptides as drugs is their typically poor oral availability, hindering their convenient and flexible application as pills. Of the more than 60 approved peptide drugs, the large majority is not orally applicable. The oral delivery of peptides is hampered by their metabolic instability and/or limited intestinal uptake. In this article, we review the barriers peptides need to overcome after their oral administration to reach disease targets, we highlight two recent successes of pharma companies in developing orally applicable peptide drugs, and we discuss efforts of our laboratory towards the generation of bioavailable cyclic peptides.

scholarly journals Nanoparticles: Oral Delivery for Protein and Peptide Drugs

2019 ◽  
Vol 20 (5) ◽  
Author(s):  
Shu-jun Cao ◽  
Shuo Xu ◽  
Hui-ming Wang ◽  
Yong Ling ◽  
Jiahua Dong ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs

Biodegradable azopolymer coating for oral delivery of peptide drugs

1990 ◽  
Vol 18 (5) ◽  
pp. 752-754 ◽  
Author(s):  
MURRAY SAFFRAN ◽  
G. SUDESH KUMAR ◽  
DOUGLAS C. NECKERS ◽  
JAMES PEÑA ◽  
RICHARD H. JONES ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Peptide Drugs
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