Modification of Freezing Point for Hydrogel Extinguishant and Its Effect on Comprehensive Properties in Simulated Forest Fire Rescue

Hydrogels, as an emerging extinguishant, exhibit outstanding performance in forest fire rescues. However, the near-zero freezing point limits their application at low temperatures. Herein, a sensible candidate commercial extinguishant was selected for analysis, and its freezing point was modified based on the evaluation of water absorption rate, agglomeration, viscosity, and water dispersibility. Notably, the introduction of different antifreeze and flame retardant exhibited a significant disparate impact on the viscosity representative factor. Ten orthogonal experiments were performed to optimize the specific formulation. When ethylene glycol, urea and ammonium bicarbonate, and xanthan gum were applied as antifreeze, flame retardant, and thickener, with the addition amounts of 5 mL, 0.08 g and 0.04 g, and 0.12 g, respectively, the hydrogel extinguishant with 1% ratio in 50 mL of ultra-water featured the remarkable performance. Compared with the original extinguishant, the freezing point of the modified sample decreased from −0.3 to −9.2 °C. The sample’s viscosity was improved from 541 to 1938 cP, and the flame retardance time was more than 120 s. The results of corrosion and biotoxicity show that the optimized hydrogel extinguishant satisfies the national standards. This understanding provides a deeper insight into the application of low-temperature extinguishants in forest fires.

Indigeneity versus diversity

The article deals with the representation of the Sámi in the new national curriculum for primary and lower secondary education in Norway. More precisely, it focuses on a specific formulation in the fourth core element of the curriculum for religious education, in which an awareness of Sámi perspectives is presented as part of the diversity competence which pupils are supposed to acquire. Based on a critical analysis of governmental documents dealing with education it is argued that the term ‘diversity’ as it is used in the fourth core element addresses Sámi perspectives in a way that may induce readers to think of the Sámi as one of an increasing number of minorities in an originally Norwegian society. This implication, even if unintended, is highly problematic. It can be interpreted as a violation of both ILO 169, Article 31 and CRC, Article 29 (1), especially since the Sámi are a people indigenous to Norway.

A note on cut-elimination for classical propositional logic

In Schwichtenberg (Studies in logic and the foundations of mathematics, vol 90, Elsevier, pp 867–895, 1977), Schwichtenberg fine-tuned Tait’s technique (Tait in The syntax and semantics of infinitary languages, Springer, pp 204–236, 1968) so as to provide a simplified version of Gentzen’s original cut-elimination procedure for first-order classical logic (Gallier in Logic for computer science: foundations of automatic theorem proving, Courier Dover Publications, London, 2015). In this note we show that, limited to the case of classical propositional logic, the Tait–Schwichtenberg algorithm allows for a further simplification. The procedure offered here is implemented on Kleene’s sequent system G4 (Kleene in Mathematical logic, Wiley, New York, 1967; Smullyan in First-order logic, Courier corporation, London, 1995). The specific formulation of the logical rules for G4 allows us to provide bounds on the height of cut-free proofs just in terms of the logical complexity of their end-sequent.

47. Transitioning to Batch Dosing of High-Cost Antimicrobials in the Inpatient Setting

Background Antimicrobial stewardship (AMS) committees ensure appropriate antimicrobial utilization. One stewardship intervention is to evaluate the delivery model of high-cost antimicrobials to better utilize resources and mitigate expenses. We analyzed the total medication waste and costs of high-cost antimicrobials, specifically daptomycin, ertapenem, amphotericin, and micafungin, at our institution and propose innovative cost-savings changes at a systems level. Methods This retrospective study consisted of 263 patients. All patients were at least 18 years old who was admitted to our academic institution from January 2020 to April 2021 and received daptomycin, ertapenem, amphotericin, or micafungin. Demographics, daily medication dosage, total doses received, the date and time of the start of the medication, last administered dose, and discontinued order were recorded. Results The daptomycin cohort consisted of 143 patients with 46.2% females and average age of 56.3 years. In this group, 145.3 vials were wasted which equated to a loss of &22,630. The ertapenem group had 53 patients with 62.3% females and a mean age of 62.3 years. There were 24 vials wasted with a calculated loss of &1080. The amphotericin cohort had 32 patients with an average age of 52.2 years and 43.8% females. There were 189 vials wasted with a loss of &46,116. The micafungin group had 35 patients with 42.9% females and average age of 60.4 years. This group had 12 vials wasted with a loss of &2052. Conclusion Each antimicrobial has a specific formulation protocol. Daptomycin and ertapenem formulation occurs in the early morning. Amphotericin formulation occurs 2 hours prior to medication use. Micafungin formulation occurs at the time the order label prints. These medications were more often administered in the late morning to early afternoon timeframe. The order to discontinue the medications also occurred at the same interval. One reason could be due to decisions made on morning rounds from primary teams and specialty input. These orders would then be placed after rounds. A cost-saving method would be to batch and change the formulation time for all antimicrobials to later in the afternoon, which would not only prevent waste, but also allow the AMS team to effectively audit appropriate antimicrobial use. Disclosures All Authors: No reported disclosures

Optimization of Site-Specific Drug Delivery System of Tyrosine Kinase Inhibitor Using Response Surface Methodology

Aims: The aim of present study was to develop a stomach specific formulation of Imatinibmesylate to increase the fraction of drug absorbed in stomach. Study Design: Development and Optimization of Microspheres for site specific delivery.. Place and Duration of Study: The study was carried out in Department of Pharmacy, Annamalai University, between October 2020 and July 2021. Methodology: Ionotropic gelation method with Sodium alginate and Chitosan were used to formulate the mucoadhesive microspheres with calcium chloride. The formulation was optimized using Box – Behnken design to study the effect of independent variables, Amount of Sodium Alginate (X1), Amount of Chitosan (X2) and concentration of Calcium Chloride (X3) on dependent variables Particle Size (Y1), Entrapment Efficiency (Y2) and In-vitro drug release (Y3). Results: Particle size of prepared microspheres varied from 458.25 to 810.75 μm, entrapment efficiency from 64.87 to 82.63% and in-vitro release from 69.22 to 83.50%. The optimized formulation was found using point prediction, and formulation showed optimum results. The drug release was controlled for more than 12 h. Conclusion: Stomach specific formulation of Imatinibmesylate was successfully optimized by a three-factor, three level Box – Behnken design.

PHYSICO-CHEMICAL CHARACTERISATION OF UTTAMARASASINDURA: A VALUABLE KUPIPAKWARASAYANAFROM RASARAJACINTAMANI

Ayurveda, literally means the science of life is a comprehensive system of health care of great antiquity, based on experiential knowledge and grown with perpetual additions. Rasashatra(Iatrochemistry)is an integrated part of Ayurveda which is based on Rasa (Mercury) and Rasadravyas(Mercury related substances). Rasarajacintamani is a compiled textbook of Rasashastra written in Malayalam language by Vadayattukotta K ParameshwaranPillai.Uttamarasasindura is explained in this textbook along with different types of Rasasinduras. The treatise Rasarajacintamani is reviewed for the specific formulation, Uttamarasasindura. Analytical study is needed to evaluate the proper formation and chemical composition of the medicine.Contexual reviewing revealed that Uttamarasasindura is a multidimensional remedy of clinical practice.

Characteristic Features and Comparative Analysis of Essential Oil Composition of Selected Species of Ocimum Sanctum L. Through GCMS

Background: The main aim of this research is to provide a literature of the Ocimum plant, to know the significance of the Ocimum species carried out by pharmacognostical study and experimental design for GC-MS.Ocimum are very important for their therapeutic potentials. among the most important aromatic herbs for its enormous medicinal properties.Methods: An extreme Attention has been put on those literature reports wherein the utilization of Tulsi and their pharmacognostical study has been done by performing morphological and microscopic leaf and experimental design by using essential oil by GC-MS instrumentation methodResults: The utilization of these characteristics would be important for the drug discovery scientist to develop a specific formulation of the crude drug, which will be a magical therapeutic agent in the future, with the many advantageous. GC-MS chromatogram of the Ocimum sanctum, Ocimum canum and Ocimum gratissimum oil showed major peaks and has been identified after comparison of the mass spectra with NIST library, indicating the presence of three phytocomponents. From the results GC-MS study suggested that anethole which is well reported antimicrobial compound is more in O. canum (2.66%) in comparison to O. sanctum (1,28%) but absent in O. Gratissimum. The results indicated that the antimicrobial activity is more in O. canum due to presence high amount of anethole in comparison to O.Gratissimum, and O. Sanctum. The GC-MS study suggested that anethole which is well reported antimicrobial compound is more in O. canum (2.66%) in comparison to O. sanctum (1,28%) but absent in O. Gratissimum.Conculsion: The result showed that microscopic character of O. canum, with the characteristic GC MS analysis of the extracts, to identify different species of the ocimum plant. Ocimum sanctum L. and further experiments are required for better exploitation of essential oil for its commercial purposes.

Characteristic Features and Comparative analysis of essential oil composition of selected species of Ocimum sanctum L. through GCMS

Background: The main aim of this research is to provide a literature of the Ocimum plant, to know the significance of the Ocimum species carried out by pharmacognostical study and experimental design for GC-MS.Ocimum are very important for their therapeutic potentials. Among the most important aromatic herbs for its enormous medicinal properties.Methods: An extreme Attention has been put on those literature reports wherein the utilization of Tulsi and their pharmacognostical study has been done by performing morphological and microscopic leaf and experimental design by using essential oil by GC-MS instrumentation method Results: The utilization of these characteristics would be important for the drug discovery scientist to develop a specific formulation of the crude drug, which will be a magical therapeutic agent in the future, with the many advantageous. GC-MS chromatogram of the Ocimum sanctum, Ocimum canum and Ocimum gratissimum oil showed major peaks and has been identified after comparison of the mass spectra with NIST library, indicating the presence of three phytocomponents. From the results GC-MS study suggested that anethole which is well reported antimicrobial compound is more in O. canum (2.66%) in comparison to O. sanctum (1,28%) but absent in O. Gratissimum. The results indicated that the antimicrobial activity is more in O. canum due to presence high amount of anethole in comparison to O.Gratissimum, and O. Sanctum. The GC-MS study suggested that anethole which is well reported antimicrobial compound is more in O. canum (2.66%) in comparison to O. sanctum (1,28%) but absent in O. Gratissimum. Conclusion: The result showed that microscopic character of O. canum, with the characteristic GC MS analysis of the extracts, to identify different species of the ocimum plant. Ocimum sanctum L. and further experiments are required for better exploitation of essential oil for its commercial purposes.

Comparison of Gelatin Flavors for Oral Dosing of C57BL/6J and FVB/N Mice

Precise oral dosing in rodents is usually achieved by intragastric gavage. If performed incorrectly due to technical difficulties, inexperience, or animal resistance, oral gavage may have animal welfare implications such as esophageal and gastric rupture and aspiration. The stress that is induced by this procedure can also lead to confounding results. In several animal models, drug vehicles must be sugar-free, deliver drugs in a specific formulation, and sometimes supply water. Gelatin has all of these properties. The current study aimed to evaluate the use of gelatin vehicles with different sensory features as an alternative to oral gavage. We investigated the time taken by 2 different inbred mouse strains, FVB/N and C57BL/6J, to ingestsugar-free gelatin pellets of varying flavors. Results showed that FVB/N mice took more time to eat the unflavored, strawberryand diet-flavored gelatin pellets than did C57BL/6J mice. Both strains showed low preference for lemon flavor, with the sameingestion times after the second day. This study showed that the C57BL/6J mice are more likely to eat gelatin than are FVB/Nmice, and that the 2 strains of mice show a lower preference for lemon flavoring as compared with other flavors. This methodof voluntarily oral administration offers an alternative to gavage for studies that use oral dosing studies.