scholarly journals Griseorubins, a new family of antibiotics with antimicrobial and antitumor activity. II. Biological properties and antitumor activity of the antibiotic complex griseorubin.

1980 ◽  
Vol 33 (1) ◽  
pp. 9-12 ◽  
Author(s):  
K. DORNBERGER ◽  
U. BERGER ◽  
W. GUTSCHE ◽  
W. JUNGSTAND ◽  
K. WOHLRABE ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Biological Properties ◽  
New Family

STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES

2021 ◽  
Vol 55 (2 (255)) ◽  
pp. 103-111
Author(s):  
Tariel V. Ghochikyan ◽  
Armen S. Galstyan ◽  
Hrachik M. Stepanyan ◽  
Irina G. Korpakova ◽  
Alexander S. Kinzirsky
Keyword(s):  
Antitumor Activity ◽  
Green Alga ◽  
Biological Properties ◽  
Lymphocytic Leukemia ◽  
Thiazole Ring ◽  
Lewis Lung ◽  
Ehrlich's Ascites Tumor ◽  
Carbonyl Derivatives ◽  
Derivatives Of ◽  
Test Objects

Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

Substituted tetrahydroisoquinolines: synthesis, characterization, antitumor activity and other biological properties

2018 ◽  
Vol 145 ◽  
pp. 51-63 ◽  
Author(s):  
A. Sergi Capilla ◽  
Richard Soucek ◽  
Laura Grau ◽  
Manel Romero ◽  
Jaime Rubio-Martínez ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Biological Properties

scholarly journals A New Family of Homoleptic Copper Complexes of Curcuminoids: Synthesis, Characterization and Biological Properties

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 910 ◽  
Author(s):  
William Meza-Morales ◽  
Juan Machado-Rodriguez ◽  
Yair Alvarez-Ricardo ◽  
Marco Obregón-Mendoza ◽  
Antonio Nieto-Camacho ◽  
...  
Keyword(s):  
Single Crystal ◽  
Crystal Structures ◽  
Copper Complexes ◽  
Biological Properties ◽  
Planar Geometry ◽  
X Ray Diffraction ◽  
Paramagnetic Resonance ◽  
X Ray ◽  
New Family ◽  
Homoleptic Complex

We report herein the synthesis and crystal structures of five new homoleptic copper complexes of curcuminoids. The scarcity of reports of homoleptic complex structures of curcuminoids is attributed to the lack of crystallinity of such derivatives, and therefore, their characterization by single crystal X-ray diffraction is rare. The ligand design suppressing the phenolic interaction by esterification or etherification has afforded a significant increase in the number of known crystal structures of homoleptic metal complexes of curcuminoids revealing more favorable crystallinity. The crystal structures of the present new copper complexes show four-fold coordination with a square planar geometry. Two polymorphs were found for DiBncOC-Cu when crystallized from DMF. The characterization of these new complexes was carried out using infrared radiation (IR), nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), and single crystal X-ray diffraction (SCXRD) and the antioxidant and cytotoxic activity of the obtained complexes was evaluated.

scholarly journals β -(1,4)-Polyglucuronic Acids – An Overview

2008 ◽  
Vol 2 (1) ◽  
pp. 73-86 ◽  
Author(s):  
M.L. Tavernier ◽  
C. Delattre ◽  
E. Petit ◽  
P. Michaud
Keyword(s):  
Large Scale ◽  
Biological Properties ◽  
Oxidized Cellulose ◽  
Actual Knowledge ◽  
New Family ◽  
Polysaccharide Lyases ◽  
Acidic Polysaccharides ◽  
Biodegradation Study ◽  
Polyglucuronic Acid ◽  
New Generation

Polyuronides are an acidic class of polysaccharides with interesting rheological and biological properties. However, except pectin and alginate, the structural variability of this class of polysaccharides is poor and low described in literature. In this context, a new generation of polyuronides has been isolated from two sources in the middle of the 90’s. Firstly, a bacterial β -(1,4) polyglucuronic acid called glucuronan was identified as the sole exopolysaccharide produced by a bacteria belonging to the Rhizobiaceae family. Secondly, the development of the TEMPO chemistry led to the production at large scale of oxidized cellulose called cellouronate. Both new polyuronides were largely patented and found applications in several industrial areas. Moreover, the biodegradation study of these polysaccharides has led to the identification of a new family of polysaccharide lyases very specific for these substrates. This review focuses on the actual knowledge of this class of acidic polysaccharides and on the enzymes acting about them.

Syntheses and biological properties of novel aza-podophyllotoxin analogs prossessing pronounced antitumor activity

1995 ◽  
Vol 5 (10) ◽  
pp. 1039-1042 ◽  
Author(s):  
Yukio Hitotsuyanagi ◽  
Keiji Yamagami ◽  
Akihiro Fujii ◽  
Yoichi Naka ◽  
Yukiyasu Ito ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Biological Properties
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