scholarly journals Ozonetherapy for wound management in dogs [abstract]

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Susana Gabriela Gayon-Amaro ◽  
Eduardo Flores-Colin
Keyword(s):  
Therapeutic Option ◽  
Local Treatment ◽  
Wound Management ◽  
Ozone Therapy ◽  
Recovery Processes ◽  
Plastic Materials ◽  
Purulent Wounds ◽  
Management Protocol ◽  
Infected Wounds ◽  
Polyethylene Bags

PURPOSE: To demonstrate the bactericide and regenerative capabilities of ozone through the execution of established protocols for infected wounds management. MATERIAL AND METHODS: - Ozone generator - Medical oxygen - Drinking water - Nelaton lead - Gauzes - Polyethylene bags of different sizes - 10 ml syringes - 30G needles Collect information of clinical cases of 5 patients with purulent wounds caused by bite of congener treated with ozone therapy (OP) with bagging technique (1) – injury washing with ozonized water and posterior bagged of affected area with polyethylene for 15 minutes with an ozone concentration of 56 mg/L and infiltration of wound edges with the gas in an anti-inflammatory concentration of 33 mg/L. It was possible to observe short recovery processes of disinfection and regeneration of infected wounds using in only OP as wound management protocol. DISCUSSION: Ozone bactericide property is probably the most studied topic because it was early used in the management of infected wounds (2,3). Later, with the invention of plastic materials, local treatment of septic limbs with gaseous ozone became possible. The regeneration helped with ozone has been intensively described, the acceleration of the process is related with cytokines release and the increase of tisular oxygenation (4). CONCLUSION: Based on that, it is possible to conclude that ozonetherapy could be used as another therapeutic option in the management of infected wounds with bagging technique due to bactericide and regenerative properties of this gas.

EP.TU.854Happy Patients and Updated Open Wound Management Protocols

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Harish Peri ◽  
Rafique Umer Harvitkar
Keyword(s):  
Chronic Wound ◽  
Clinical Audit ◽  
Wound Dressings ◽  
Wound Management ◽  
Open Wound ◽  
Current Management ◽  
Pdsa Cycle ◽  
Management Protocol ◽  
Open Injuries

Abstract Introduction Open injuries have a potential for serious bacterial wound infections and may lead to long term disabilities, chronic wound or bone infection, and even death. This QI study was undertaken to ring in changes to the current management protocol and align them as per WHO guidelines. Method Implementing changes through a Plan-Do-Study-Act (PDSA) cycle post an initial clinical audit among 38 patients of the organization. Re-audits were done to measure the outcome against the standard and establish a new protocol. Results Initial audit showed only a dismal 37% (n = 14) of patients being managed as per WHO protocol. Patient satisfaction percentage (as measured by a questionnaire) was also low with only 54% of patients satisfied with the treatment. Significant variations were noted post implementation of changes after the first PDSA cycle where >90% (n = 35) of patients reported that they noticed better wound healing, transition to optimal performance and were satisfied with treatment outcomes. Conclusions Timely wound dressings, appropriate antibiotic prophylaxis and increased patient’s awareness on wound hygiene through means of regular educational sessions and updated management protocols have led to healthier patients, lesser long term disabilities and happy patients.

scholarly journals Case Report: Rechallenge With BRAF and MEK Inhibitors in Metastatic Melanoma: A Further Therapeutic Option in Salvage Setting?

2021 ◽  
Vol 11 ◽  
Author(s):  
Anna Stagno ◽  
Sabrina Vari ◽  
Alessio Annovazzi ◽  
Vincenzo Anelli ◽  
Michelangelo Russillo ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Clinical Benefit ◽  
Kinase Inhibitors ◽  
Checkpoint Inhibitors ◽  
Therapeutic Option ◽  
Local Treatment ◽  
Standard Of Care ◽  
Serum Levels ◽  
High Serum ◽  
Mek Inhibitors

BackgroundThe combination of BRAF and MEK inhibitors represents the standard of care treatment for patients with metastatic BRAF-mutated melanoma, notwithstanding the high frequency of emergent resistance. Moreover, therapeutic options outside clinical trials are scarce when patients have progressed after both targeted therapy and therapy with immune checkpoint inhibitors. In this article, we report our experience with targeted therapy rechallenging with BRAF and MEK inhibitors in patients with metastatic BRAF-mutated melanoma after progression with kinase inhibitors and immunotherapy.MethodsFour patients with metastatic BRAF-mutated melanoma were rechallenged with BRAF and MEK inhibitors after progression with targeted therapy and subsequent immunotherapy (checkpoint inhibitors).ResultsTwo patients (one of them was heavily pretreated) had partial response over 36 months (with local treatment on oligoprogression disease) and 10 months, respectively. A third patient with multisite visceral disease and high serum levels of lactate dehydrogenase had a short-lived clinical benefit rapidly followed by massive progression of disease (early progressor). The fourth patient, currently on treatment with BRAF/MEK inhibitors, is showing a clinical benefit and radiological stable disease over 3 months of therapy. Adverse events were manageable, similar to those reported during the first targeted therapy; the treatment was better tolerated at rechallenge compared with the first treatment by two out of four patients.

Treating diabetic foot syndrome at the General Surgery Clinic of the S.M. Kirov Military Medical Academy

2021 ◽  
Vol 2 (3(5)) ◽  
pp. 20-29
Author(s):  
S.Ya. Ivanusa ◽  
◽  
B.V. Risman ◽  
A.V. Yanishevsky ◽  
R.E. Shayakhmetov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Magnetic Resonance ◽  
Diabetic Foot ◽  
Local Treatment ◽  
Diagnostic Algorithm ◽  
Ultrasonic Cavitation ◽  
Diabetic Foot Syndrome ◽  
Control Group ◽  
Physical Methods ◽  
Purulent Wounds

We examined 180 patients with purulent-necrotic complications of diabetic foot syndrome, in whom the proposed diagnostic algorithm was used. Magnetic resonance imaging of the feet, ultrasound Doppler with duplex angioscanning, magnetic resonance and computed angiography of the lower extremities, as well as assessment of transcutaneous oxygen tension were performed. Surgical treatment tactics depended on the form of the diabetic foot syndrome, as well as the severity of the disease. As a local treatment, physical methods were used to accelerate the course of the wound process. The proposed diagnostic algorithm for the diagnosis and selection of surgical treatment for various forms of diabetic foot syndrome has made it possible to reduce the number of “high” amputations and maintain a supporting limb. Purpose of the study is to improve treatment outcomes for purulent-necrotic complications of diabetic foot syndrome by developing and applying a diagnostic algorithm and differentiated treatment tactics. The main group consisted of 180 patients with purulent-necrotic complications of diabetic foot syndrome, in whom the developed diagnostic algorithm and differentiated tactics of surgical treatment were used, as well as physical methods of influencing the wound process (ultrasonic cavitation and local ozonation) were used as local treatment. The control group included 40 patients with purulent-necrotic complications of diabetic foot syndrome, whose treatment involved the use of drugs that improve the rheological properties of blood and tissue microcirculation (rheopolyglucin, trental, actovegin) according to conventional schemes. Local treatment included sanitation and treatment of wound and ulcerative surfaces with antiseptic solutions and ointments, depending on the phase of the wound process. Data analysis in this group was carried out based on a retrospective study of case histories and an assessment of long-term results of treatment by follow-up examinations and telephone interviews. Control group included 25 (63%) men and 15 (37%) women; the average age was 67.3±10.3 years. The developed unified approaches in diagnosing and treating patients with purulent-necrotic complications of diabetic foot syndrome, who, in complex treatment, underwent staged necrectomy with simultaneous ultrasonic cavitation of purulent wounds and their ozonization, can reliably reduce the number of ulcer recurrences from 28% to 2.7%, high amputations by 34%, and the number of re-amputations ― 10 times. The use of minimally invasive surgical technologies for the rehabilitation of deep purulent foci of the foot, in comparison with the classical principles of treatment of purulent wounds, makes it possible to achieve a complete cleansing of wounds, preparation for plastic surgery, and an increase in the number of functional supportable lower limbs by 42.7%. According to the data obtained, it is optimal to perform sanitizing operations after revascularization of at least one artery no earlier than 3–4 days, which makes it possible to increase their efficiency and reduce the number of repeated surgical interventions. The approach to managing patients with diabetic foot syndrome at all stages of treatment and rehabilitation should be interdisciplinary and include the following specialists: endocrinologist, orthopedist, surgeon, psychologist, trained nursing staff.

Use of Antibiotic-Impregnated Absorbable Beads and Tissue Coverage of Complex Wounds

2016 ◽  
Vol 82 (11) ◽  
pp. 1068-1072 ◽  
Author(s):  
Terris L. White ◽  
Alfred T. Culliford ◽  
Martin Zomaya ◽  
Gary Freed ◽  
Christopher P. Demas
Keyword(s):  
Wound Management ◽  
Fasciocutaneous Flaps ◽  
Local Antibiotics ◽  
Standard Management ◽  
Systemic Antibiotic Therapy ◽  
Infected Wounds ◽  
Complex Wound ◽  
High Concentrations ◽  
Multicenter Retrospective Review ◽  
Complex Wounds

The treatment of complex wounds is commonplace for plastic surgeons. Standard management is debridement of infected and devitalized tissue and systemic antibiotic therapy. In cases where vital structures are exposed within the wound, coverage is obtained with the use of vascularized tissue using both muscle and fasciocutaneous flaps. The use of nondissolving polymethylmethacrylate and absorbable antibiotic-impregnated beads has been shown to deliver high concentrations of antibiotics with low systemic levels of the same antibiotic. We present a multicenter retrospective review of all cases that used absorbable antibiotic-impregnated beads for complex wound management from 2003 to 2013. A total of 104 cases were investigated, flap coverage was used in 97 cases (93.3%). Overall, 15 patients (14.4%) required reoperation with the highest groups involving orthopedic wounds and sternal wounds. The advantages of using absorbable antibiotic-impregnated beads in complex infected wounds have been demonstrated with minimal disadvantages. The utilization of these beads is expanding to a variety of complex infectious wounds requiring high concentrations of local antibiotics.

scholarly journals THE EVALUATION OF THE EFFECTIVENESS OF LOCAL APPLICATION OF OZONE THERAPY FOLLOWING CRYOTHERAPY OF LESIONS OF VERRUCOUS LEUKOPLAKIA OF THE ORAL MUCOUS MEMBRANE

2017 ◽  
Vol 22 (4) ◽  
pp. 184-187
Author(s):  
Svetlana I. Tokmakova ◽  
O. V Bondarenko ◽  
J. N Shilova
Keyword(s):  
Mucous Membrane ◽  
Postoperative Period ◽  
Local Treatment ◽  
Clinical Signs ◽  
Laboratory Animals ◽  
Control Group ◽  
Ozone Therapy ◽  
Mucosal Membrane ◽  
Traditional Scheme ◽  
Clinical Changes

There are presented results of the study morphological and clinical changes of the oral mucosal membrane. In the experiment on laboratory animals the use of ozone therapy following the destruction of the mucous membrane of the mouth was proved to appear earlier with the more complete epithelization of the defect, compared to the treatment implemented according to the traditional scheme. There was performed a clinical examination of 32 patients with verrucous leukoplakia of the oral mucosal membrane, the treatment of which was carried out according to the traditional scheme (cryotherapy and topical anti-inflammatory treatment - group comparison) and with the use of the ozonized solution of olive oil with a known peroxide during the postoperative period (control group). To assess the effectiveness of the proposed method of the management of the postoperative wound there was used a point scoring system of clinical signs at stages of the postoperative period. There was revealed a more earlier onset of the complete epithelization in cases of the application of the local ozone therapy in comparison with traditional local treatment.

CYTOLOGICAL STUDY OF THE DYNAMICS OF THE WOUND PROCESS IN PURULENT LESIONS OF THE DIABETIC FOOT SYNDROME WITH THE USE OF PROGRAMMABLE REHABILITATION TECHNOLOGIES

2021 ◽  
Vol 17 (37) ◽  
pp. 212-227
Author(s):  
Vladimir Anatolievich SERGEEV ◽  
Alexander Anatolyevich GLUKHOV ◽  
Alexander Sergeevich SOROKIN
Keyword(s):  
Diabetic Foot ◽  
Local Treatment ◽  
Diabetic Foot Syndrome ◽  
Limb Amputation ◽  
Control Group ◽  
Critical Ischemia ◽  
Results Of Treatment ◽  
Purulent Wounds ◽  
Cytological Method ◽  
Experimental Group

Background: Purulent lesions of the feet in diabetes mellitus bring excruciating suffering to the patient, reduce the quality of life and often lead to limb amputation and possible death. The disappointing results of the treatment of purulent complications of diabetes encourage the search for both new approaches to treatment and methods for assessing the reparative potential of wound defects. Aim: This study aimed to improve the treatment of purulent-necrotic complications of the diabetic foot by studying the morphological assessment of healing processes when using promising treatment methods such as then programmed debridement. Methods: Over the past 10 years, the results of treatment of 106 patients with purulent-necrotic complications of diabetic foot syndrome (DFS) without critical ischemia have been analyzed. The patients were randomized into two groups. In the experimental group (n = 55), after surgical treatment, the wound was sutured tightly, and in the postoperative period, programmed debridement was carried out using the original AMP-01 device. In the control group of patients (n = 51), the purulent wound was not sutured after the operation, and local treatment was carried out with solutions of iodophors, ointments based on polyethylene glycol. To assess the dynamics of reparative processes in purulent wounds, a cytological method was used, which makes it possible to quickly and reliably assess the stage of the wound process and the effectiveness of the treatment. The simplicity and availability of the method allows it to be recommended to all practicing specialists. Results and Discussion: In the experimental group, by day 9 after surgery, the number of degenerative forms of neutrophils in cytological smears was 2.9 times lower than in the control group - 12.3 ± 0.3% versus 36.4 ± 0.4% (p 0.001) - and the RDI indicator in experimental group was 3.4 times higher compared with the control group - 2.6 ± 0.1 and 0.9 ± 0.1, respectively (p 0.001). This indicated more active phagocytosis, more rapid cleansing of the purulent cavity. An earlier appearance of cells of young connective tissue was observed in the experimental group. The number of fibroblasts by day 9 after surgery was 4.6 times higher (6.4 ± 0.4%) than in the control group - 1.4 ± 0.1% (p 0.001), which confirmed the presence of active regenerative processes in the wound. Conclusions: The use of programmable sanitation technologies in treating purulent complications of a diabetic foot leads to a more significant reduction in the duration of the inflammation phase and acceleration of reparative processes

AEROGELS' BIOSAFETY ASSESSMENT IN LOCAL TREATMENT OF PURULENT WOUNDS

2021 ◽  
Vol 24 (5) ◽  
pp. 38-45
Author(s):  
O.A. Legonkova ◽  
A.I. Korotaeva ◽  
V.V. Stafford ◽  
A.S. Ogannisyan ◽  
R.P. Terekhova
Keyword(s):  
Local Treatment ◽  
Purulent Wounds ◽  
Biosafety Assessment

Change in oxygen tension in the capillary blood of tissues of infected wounds during local hyperbaric oxygenation

1980 ◽  
Vol 61 (4) ◽  
pp. 46-47
Author(s):  
G. M. Nikolaev ◽  
V. M. Sigitov
Keyword(s):  
Oxygen Tension ◽  
Hyperbaric Oxygenation ◽  
Capillary Blood ◽  
Local Application ◽  
Purulent Wounds ◽  
Infected Wounds ◽  
Purulent Wound ◽  
Positive Effect

84 patients with purulent wounds were treated with local application of oxygen under pressure using mobile portable pressure chambers. The study of the dynamics of pO2 in a purulent wound confirms the positive effect of this method of hyperbaric oxygenation on the local hypoxia of a purulent wound and on its healing.

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