scholarly journals Peer Review #1 of "Risk and clinical predictors of osteoporotic fracture in East Asian patients with chronic obstructive pulmonary disease: a population-based cohort study (v0.2)"

2016 ◽  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cohort Study ◽  
Osteoporotic Fracture ◽  
East Asian ◽  
Population Based ◽  
Chronic Obstructive ◽  
Clinical Predictors ◽  
Obstructive Pulmonary Disease ◽  
Asian Patients ◽  
East Asian Patients

scholarly journals Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease

2017 ◽  
Vol Volume 12 ◽  
pp. 3329-3339 ◽  
Author(s):  
Chunxue Bai ◽  
Masakazu Ichinose ◽  
Sang Haak Lee ◽  
Kwan Ho Lee ◽  
Olaf Jöns ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
East Asian ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Asian Patients ◽  
East Asian Patients

scholarly journals Risk and clinical predictors of osteoporotic fracture in East Asian patients with chronic obstructive pulmonary disease: a population-based cohort study

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2634 ◽  
Author(s):  
Ping-Hsueh Lee ◽  
Victor C. Kok ◽  
Po-Liang Chou ◽  
Ming-Chang Ku ◽  
Yu-Ching Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
East Asian ◽  
Population Based ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Asian Patients ◽  
Copd Patients ◽  
Increased Risk

IntroductionOsteoporosis is becoming an impending epidemic in the Asia-Pacific region. The association between risk of osteoporotic fracture (OTPF) and chronic obstructive pulmonary disease (COPD) in East Asian patients is yet to be fully examined. We conducted a nationwide population-based retrospective cohort study of 98,700 patients aged ≥50 years with or without COPD using a national administrative claims dataset.Materials and MethodsThe patients were divided into COPD and comparison groups comprising 19,740 and 78,960 patients, respectively. The groups were 1 to 4 matched for age, gender, index date, diabetes mellitus, pre-existing osteoporosis and chronic kidney disease. Information such as the geographic area where southern part represented more sunshine exposure, smoking-related diagnoses, alcohol use disorder, whether there was regular use of inhaled corticosteroids and oral corticosteroids, vitamin D prescriptions, Charlson-Deyo comorbidity index score, and other relevant medical comorbidities were extracted for analysis. They were followed up until OTPF or the end of the year 2013. The outcome measure was an osteoporotic vertebral fracture and other long-bone fractures. A multivariate Cox model was constructed to derive adjusted hazard ratios (aHR) for OTPF with corresponding 95% confidence intervals (CI) after controlling for age, sex, insurance premium category, vitamin D prescription, osteoporosis, and coronary heart disease (CHD). Kaplan–Meier curves of the probability of OTPF-free survival for each cohort were compared using the log-rank test. Patients with OTPF during the first follow-up year were excluded from the overall risk calculation. Contributing factors to the increased risk of OTPF in COPD patients were examined in a sensitivity analysis.ResultsAfter a total follow-up of 68,743 patient-years for the COPD group and 278,051 patient-years for the matched comparison group, the HR for OTPF was 1.24 (95% CI [1.02–1.51];P = 0.0322) in COPD patients. The aHR was increased by 30% for vertebral OTPF (aHR = 1.297, 95% CI [1.020–1.649];P = 0.0339). Differential lag time sensitivity analysis revealed a progressively elevated risk up to 8-fold increase in women (aHR = 8.0 (95% CI [1.81–35.4];P < 0.01)) during the fifth follow-up year. COPD patients with pre-existing osteoporosis or given vitamin D prescription harbor a sustained increased risk up to the 5th (aHR, 4.1; 95% CI [1.61–10.35]) and third (aHR, 2.97; 95% CI [1.48–5.97]) follow-up year, respectively.ConclusionsOur nationwide population-based cohort study demonstrates that East Asian COPD patients aged 50 and beyond do harbor a modestly increased risk for osteoporotic vertebral fractures particularly for those who are female, have pre-existing osteoporosis or require vitamin D prescription.

Statin Use and Hospitalization in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Cohort Study in Taiwan

2011 ◽  
Vol 33 (10) ◽  
pp. 1365-1370 ◽  
Author(s):  
Chin-Chou Huang ◽  
Wan-Leong Chan ◽  
Yu-Chun Chen ◽  
Tzeng-Ji Chen ◽  
Kun-Ta Chou ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cohort Study ◽  
Pulmonary Disease ◽  
Population Based ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Statin Use

scholarly journals Incidence of chronic obstructive pulmonary disease in people with HIV in Ontario, 1996–2015: a retrospective population-based cohort study

CMAJ Open ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. E83-E89 ◽  
Author(s):  
Tony Antoniou ◽  
Zhan Yao ◽  
Janet Raboud ◽  
Andrea S. Gershon
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Cohort Study ◽  
Pulmonary Disease ◽  
Population Based ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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