scholarly journals Implanted intracortical electrodes as chronic neural interfaces to the central nervous system

2015 ◽  
Author(s):  
Peter Henderson
Keyword(s):  
Immune Responses ◽  
Degrees Of Freedom ◽  
Bioactive Molecules ◽  
Neural Interfaces ◽  
Controlled Study ◽  
Mems Devices ◽  
Recent Developments ◽  
Fine Control ◽  
Intracortical Electrodes

Recent developments in neural interfaces show that it is possible to have fine control of a robotic prosthetic by interfacing with the motor cortex of the human brain. Development of long term systems for this purpose is a challenging task with many different possibilities. Intracortical implants have shown the most promise in providing enough signal selectivity and throughput for complex control systems with many degrees of freedom. Intracortical systems generally fall into two categories: MEMS devices and bundle of wire systems. While both show promise, MEMS systems have been greatly popularized due to their reproducibility. In particular, the Michigan probe and Utah microarray are often used as a base for construction of more complex intracortical systems. However, these systems still carry many downsides. Their long-term viability is questionable, with mixed results. The effects of damage from implantation are still inconclusive and immune responses remain a problem for long-term use. While there is some promising research in the use of bioactive molecules and biocompatible materials to prevent immune responses, more controlled study is needed before intracortical systems become widespread.

scholarly journals Implanted intracortical electrodes as chronic neural interfaces to the central nervous system

2015 ◽  
Author(s):  
Peter Henderson
Keyword(s):  
Immune Responses ◽  
Degrees Of Freedom ◽  
Bioactive Molecules ◽  
Neural Interfaces ◽  
Controlled Study ◽  
Mems Devices ◽  
Recent Developments ◽  
Fine Control ◽  
Intracortical Electrodes

Recent developments in neural interfaces show that it is possible to have fine control of a robotic prosthetic by interfacing with the motor cortex of the human brain. Development of long term systems for this purpose is a challenging task with many different possibilities. Intracortical implants have shown the most promise in providing enough signal selectivity and throughput for complex control systems with many degrees of freedom. Intracortical systems generally fall into two categories: MEMS devices and bundle of wire systems. While both show promise, MEMS systems have been greatly popularized due to their reproducibility. In particular, the Michigan probe and Utah microarray are often used as a base for construction of more complex intracortical systems. However, these systems still carry many downsides. Their long-term viability is questionable, with mixed results. The effects of damage from implantation are still inconclusive and immune responses remain a problem for long-term use. While there is some promising research in the use of bioactive molecules and biocompatible materials to prevent immune responses, more controlled study is needed before intracortical systems become widespread.

Effectiveness of intermittent diazepam in febrile convulsions: A long term prospective controlled study

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
E Pavlidou ◽  
M Tzitiridou ◽  
E Kontopoulos ◽  
C Panteliadis
Keyword(s):  
Controlled Study ◽  
Febrile Convulsions ◽  
Prospective Controlled Study

Long-term dentoskeletal changes of class II growing patients' treatment with the propulseur universal light appliance. A prospective controlled study

2020 ◽  
Vol 69 (2) ◽  
Author(s):  
Marco Migliorati ◽  
Sara Drago ◽  
Chiara Calzolari ◽  
Fabio Gallo ◽  
Domenico Dalessandri ◽  
...  
Keyword(s):  
Class Ii ◽  
Controlled Study ◽  
Prospective Controlled Study

Juvederm Vollure XC is Safe and Effective for Long-Term Correction of Nasolabial Folds: Results from a Multicenter, Randomized, Controlled Study

2017 ◽  
Vol 1 ◽  
pp. s78
Author(s):  
Steven Dayan ◽  
Corey S Maas ◽  
Pearl E Grimes ◽  
Kenneth Beer ◽  
Gary Monheit ◽  
...  
Keyword(s):  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Nasolabial Folds

Abstract Not AvailableDisclosures: Study supported by Allergan.

scholarly journals Inflammatory Neuropsychiatric Disorders and COVID-19 Neuroinflammation

2021 ◽  
pp. 1-55
Author(s):  
Siu Wa Tang ◽  
Daiga Helmeste ◽  
Brian Leonard
Keyword(s):  
Immune Responses ◽  
Clinical Management ◽  
Neuronal Damage ◽  
Treatment Resistance ◽  
Neuropsychiatric Disorders ◽  
Acute Stage ◽  
Management Approach ◽  
Neuropsychiatric Diseases ◽  
Anti Inflammatory

Abstract Neuropsychiatric sequalae to COVID-19 infection are beginning to emerge, like previous Spanish influenza and SARS episodes. Streptococcal infection in pediatric patients causing OCD (PANDAS) is another recent example of an infection-based psychiatric disorder. Inflammation associated with neuropsychiatric disorders has been previously reported but there is no standard clinical management approach established. Part of the reason is that it is unclear what factors determine the specific neuronal vulnerability and the efficacy of anti-inflammatory treatment in neuroinflammation. The emerging COVID-19 data suggested that in the acute stage, wide-spread neuronal damage appears to be the result of abnormal and overactive immune responses and cytokine storm is associated with poor prognosis. It is still too early to know if there are long term specific neuronal or brain regional damages associated with COVID-19, resulting in distinct neuropsychiatric disorders. In several major psychiatric disorders where neuroinflammation is present, patients with abnormal inflammatory markers may also experience less than favorable response or treatment resistance when standard treatment is used alone. Evidence regarding the benefits of co-administered anti-inflammatory agents such as COX-2 inhibitor is encouraging in selected patients though may not benefit others. Disease modifying therapies are increasingly being applied to neuropsychiatric diseases characterized by abnormal or hyperreactive immune responses. Adjunct anti-inflammatory treatment may benefit selected patients and is definitely an important component of clinical management in the presence of neuroinflammation.

scholarly journals Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair

2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Current Knowledge ◽  
Cell Delivery ◽  
Cardiac Cell Therapy ◽  
Stem Cell Treatment

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

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