scholarly journals XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Chinese Han Population: A Meta-analysis

2012 ◽  
Vol 13 (8) ◽  
pp. 3601-3604 ◽  
Author(s):  
Wei-Hong Duan ◽  
Zhen-Yu Zhu ◽  
Jun-Gui Liu ◽  
Mao-Sheng Dong ◽  
Jun-Zhou Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Xrcc1 Arg399gln ◽  
Carcinoma Risk

scholarly journals Association Between the c.3751G>A Genetic Variant of MDR1 and Hepatocellular Carcinoma Risk in a Chinese Han Population

2013 ◽  
Vol 14 (9) ◽  
pp. 5361-5365 ◽  
Author(s):  
Xiao-Fei Li ◽  
Hua-Bin He ◽  
Yan-Shuang Zhu ◽  
Jin-Ke He ◽  
Wei-Wei Ye ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Genetic Variant ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Carcinoma Risk

scholarly journals The Association between Gene Polymorphism of TCF7L2 and Type 2 Diabetes in Chinese Han Population: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59495 ◽  
Author(s):  
Haoying Dou ◽  
Enting Ma ◽  
Liqun Yin ◽  
Yinghui Jin ◽  
Hongwu Wang
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Meta Analysis ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The Association Between CTLA-4, CD80/86, and CD28 Gene Polymorphisms and Rheumatoid Arthritis: An Original Study and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Weixi Liu ◽  
Zhicheng Yang ◽  
Yan Chen ◽  
Haoyu Yang ◽  
Xiaoxian Wan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Costimulatory Molecule ◽  
Functional Class ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population

Background: Rheumatoid arthritis (RA) is related to several pivotal susceptibility genes, including cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes. Although the connection between polymorphisms of CTLA-4 and CD86 genes in different populations of RA have been studied extensively, the results are controversial.Objective: To clarify the correlation in the Chinese Han population between CTLA-4, CD80/86, and CD28 gene polymorphisms, and RA susceptibility.Methods: A case-control study (574 RA patients and 804 controls) was conducted to determine the correlation between CTLA-4 rs231775 and rs16840252 gene polymorphisms, CD86 rs17281995 gene polymorphisms, and the risk of RA for the Chinese Han population. Furthermore, an additional meta-analysis, including three single nucleotide polymorphisms (SNPs) (CTLA-4 rs231775, CTLA-4 rs3087243, and CTLA-4 rs5742909) from 32 citations, including 43 studies, 24,703 cases and 23,825 controls was performed to elucidate the relationship between known SNPs in the CTLA-4 genes and RA for more robust conclusions.Results: The results showed that CTLA-4 rs231775 gene polymorphism decreased the RA risk (GA vs. AA, OR = 0.77, P = 0.025), whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA susceptibility. Stratification analyses by RF, ACPA, CRP, ESR, DAS28, and functional class identified significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in the RF-positive and RF-negative groups. A meta-analysis of the literature on CTLA-4 gene polymorphisms and RA risk revealed that the risk of RA was decreased by CTLA-4 rs231775 gene polymorphisms.Conclusions: The CTLA-4 rs231775 gene polymorphism decreased the risk of RA, whereas CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not related to RA risk. A meta-analysis indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. To support these analytical results, additional clinical cases should be investigated in further studies.

scholarly journals Influence of polymorphisms in the Wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population

Medicine ◽  
2017 ◽  
Vol 96 (12) ◽  
pp. e6127 ◽  
Author(s):  
Qing-Min Li ◽  
Feng-Qin Zhang ◽  
Ya-Feng Li ◽  
Qing-Jie Xian ◽  
Yan-Qiang Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Carcinoma Risk
Sign in / Sign up

Export Citation Format

Share Document