scholarly journals Correlation between Low Gleason Score and Prostate Specific Antigen Levels with Incidence of Bone Metastases in Prostate Cancer Patients: When to Omit Bone Scans?

2013 ◽  
Vol 14 (9) ◽  
pp. 4973-4976 ◽  
Author(s):  
I. Putu Gde Sanjaya ◽  
Chaidir Arief Mochtar ◽  
Rainy Umbas
Keyword(s):  
Prostate Cancer ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Specific Antigen ◽  
Bone Scans

Prostate-specific antigen failure despite pathologically organ-confined and margin-negative prostate cancer: the basis for an adjuvant therapy trial.

1997 ◽  
Vol 15 (4) ◽  
pp. 1465-1469 ◽  
Author(s):  
A V D'Amico ◽  
R Whittington ◽  
S B Malkowicz ◽  
D Schultz ◽  
J E Tomaszewski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Adjuvant Therapy ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Multivariable Analysis ◽  
Specific Antigen ◽  
Radical Retropubic Prostatectomy ◽  
Phase Iii ◽  
Psa Failure

PURPOSE A multivariable analysis to evaluate the potential clinical and pathologic factors that predict for early biochemical failure in patients with pathologically organ-confined and margin-negative disease was performed to define patients who may benefit from adjuvant therapy. PATIENTS AND METHODS Three hundred forty-one prostate cancer patients treated with a radical retropubic prostatectomy between January 1989 and June 1995 and found to have pathologically organ-confined and margin-negative disease comprised the study population. A logistic regression multivariable analysis to evaluate the predictive value of the preoperative prostate-specific antigen (PSA) level, pathologic (prostatectomy) Gleason score, and pathologic stage on PSA failure occurring during the first postoperative year was performed. RESULTS Predictors of PSA failure during the first postoperative year in patients with pathologically organ-confined disease included pathologic Gleason score > or = 7 (P = .0007) and preoperative PSA level greater than 10 (P < .0001). Corresponding 3-year freedom-from-PSA-failure rates for these pathologic organ-confined patients with both, one, or neither of these factors were 60%, 75% to 84%, and 95%, respectively (P < .0001). CONCLUSION Prostate cancer patients with pathologically organ-confined and margin-negative disease and a preoperative PSA level greater than 10 ng/mL or a pathologic Gleason score > or = 7 have significant decrements in short-term PSA-failure-free survival. Therefore, these patients should be considered for adjuvant therapy in the setting of a phase III clinical trial.

SUN-P100: Tomato Intake, Gleason Score, and Prostate Specific Antigen in Prostate Cancer Patients

2017 ◽  
Vol 36 ◽  
pp. S91
Author(s):  
I. Paur ◽  
M.H. Carlsen ◽  
W. Lilleby ◽  
N. Bolstad ◽  
T. Bjoro ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Specific Antigen

The relationship between prostate-specific antigen and TNM classification or Gleason score in prostate cancer patients with low prostate-specific antigen levels

The Prostate ◽  
2015 ◽  
Vol 75 (10) ◽  
pp. 1034-1042 ◽  
Author(s):  
Kouji Izumi ◽  
Hiroko Ikeda ◽  
Aerken Maolake ◽  
Kazuaki Machioka ◽  
Takahiro Nohara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Tnm Classification ◽  
Specific Antigen ◽  
The Relationship

scholarly journals Prognostic Significance of Free Psa/ Total Psa Ratio In Predicting Bone Metastases In Patients With Prostate Cancer

2020 ◽  
Author(s):  
Semra OZDEMIR ◽  
Ahmet Resit ERSAY ◽  
Fulya Koc OZTURK ◽  
Beril Su OZDEMIR
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Bone Metastases ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Specific Antigen ◽  
Free Psa ◽  
Reliable Parameter ◽  
Metastasis Development ◽  
Total Psa

Abstract Background In this study, we aimed to investigate the prognostic value of free prostate specific antigen/total prostate specific antigen (free PSA/ total PSA) ratio in prediciton of bone metastases in patient with prostate cancer. Methods In total 175 patients with prostate cancer who underwent whole-body bone scintigraphy were included in the study. All selected scintigraphic studies were reprocessed. Free PSA/total PSA ratio, alkaline phosphatase(ALP) values and Gleason scores of patients were recorded. Results The results of our study shows that a moderate correlation between free PSA and ALP values with bone metastases lesion number. In addition, we detected a weak correlation between total PSA value, free PSA/ total PSA ratio and Gleason score with the number of bone metastases lesions in patients with prostate cancer. To predict bone metastases in prostat cancer, only ALP variable was statistically significant and had a high diagnostic value (AUC = 0.907, p = 0.004). ALP cut off value was 76.50 IU/L, with %80 sensitivity and %82.1 specificity. Additionally according to our results free PSA values, total PSA values, free PSA/total PSA ratio and Gleason score values was not considered as a reliable parameter in prostate cancer cases following bone metastasis development. Conclusion According to the results of our study; the free PSA, total PSA, free PSA/total PSA ratio and Gleason score values was not considered as a reliable parameter in the prostate cancer cases follow-up for bone metastasis development. In addition to ALP can predict bone metastases with 80% sensitivity and 82.1% specificity at 76.50 cut off value.

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