scholarly journals Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies

2008 ◽  
Vol 149 (7) ◽  
pp. 461 ◽  
Keyword(s):  
Prostate Cancer ◽  
Growth Factors ◽  
Cancer Risk ◽  
Risk Analysis ◽  
Prospective Studies ◽  
Binding Proteins ◽  
Individual Patient Data ◽  
Prostate Cancer Risk ◽  
Patient Data ◽  
Insulin Like Growth Factors

scholarly journals IGF-I, insulin and prostate cancer

2009 ◽  
Vol 53 (8) ◽  
pp. 969-975 ◽  
Author(s):  
Giovanna A. Balarini Lima ◽  
Lívia L. Corrêa ◽  
Rafael Gabrich ◽  
Luiz Carlos D. de Miranda ◽  
Mônica R. Gadelha
Keyword(s):  
Prostate Cancer ◽  
Growth Factors ◽  
Cancer Risk ◽  
Cancer Cells ◽  
Growth Regulation ◽  
Specific Antigen ◽  
Prostate Cancer Risk ◽  
Adult Men ◽  
Igf I ◽  
High Insulin

Prostate cancer is the second most frequent malignancy diagnosed in adult men. Androgens are considered the primary growth factors for prostate normal and cancer cells. However, other non-androgenic growth factors are involved in the growth regulation of prostate cancer cells. The association between IGF-I and prostate cancer risk is well established. However, there is no evidence that the measurement of IGF-I enhances the specificity of prostate cancer detection beyond that achievable by serum prostate-specific antigen (PSA) levels. Until now, there is no consensus on the possible association between IGFBP-3 and prostate cancer risk. Although not well established, it seems that high insulin levels are particularly associated with risk of aggressive prostatic tumours. This review describes the physiopathological basis, epidemiological evidence, and animal models that support the association of the IGFs family and insulin with prostate cancer. It also describes the potential therapies targeting these growth factors that, in the future, can be used to treat patients with prostate cancer.

scholarly journals Circulating Fatty Acids and Prostate Cancer Risk: Individual Participant Meta-Analysis of Prospective Studies

2014 ◽  
Vol 106 (9) ◽  
Author(s):  
Francesca L. Crowe ◽  
Paul N. Appleby ◽  
Ruth C. Travis ◽  
Matt Barnett ◽  
Theodore M. Brasky ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acids ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Prostate Cancer Risk ◽  
Individual Participant

scholarly journals A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk

2018 ◽  
Vol 79 (1) ◽  
pp. 274-285 ◽  
Author(s):  
Ruth C. Travis ◽  
Aurora Perez-Cornago ◽  
Paul N. Appleby ◽  
Demetrius Albanes ◽  
Corinne E. Joshu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Prostate Cancer Risk ◽  
Individual Participant Data ◽  
Individual Participant ◽  
Collaborative Analysis

scholarly journals Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies

2018 ◽  
Vol 74 (5) ◽  
pp. 585-594 ◽  
Author(s):  
Eleanor L. Watts ◽  
Paul N. Appleby ◽  
Aurora Perez-Cornago ◽  
H. Bas Bueno-de-Mesquita ◽  
June M. Chan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prospective Studies ◽  
Prostate Cancer Risk ◽  
Free Testosterone ◽  
Collaborative Analysis
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