Serum Periostin Levels in Patients with Moderate to Severe Persistent Bronchial Asthma

2019 ◽  
Author(s):  
Denitsa G. Dimitrova ◽  
Vania M. Youroukova ◽  
Kalina Tumangelova-Yuzeir ◽  
Ekaterina I. Ivanova-Todorova ◽  
Tsvetelina V. Velikova
Keyword(s):  
Bronchial Asthma ◽  
Serum Periostin ◽  
Persistent Bronchial Asthma

CLINICAL AND SPIROGRAPHIC FEATURES OF BRONCHIAL ASTHMA IN SCHOOLCHILDREN DEPENDING ON THE DIFFERENT REGIMENS OF BASIC ANTI-INFLAMMATORY THERAPY

2020 ◽  
Vol 73 (1) ◽  
Author(s):  
Olena Koloskova ◽  
Tetiana Bilous ◽  
Galyna Bilyk ◽  
Kristina Buryniuk-Glovyak ◽  
Olena Korotun ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroids ◽  
Persistent Asthma ◽  
High Specificity ◽  
Clinical Feature ◽  
Clinical Group ◽  
Comparison Groups ◽  
Anti Inflammatory ◽  
High Doses ◽  
Persistent Bronchial Asthma

The aim: To study the clinical and spirographic features persistence of the bronchial asthma in schoolchildren against the background of the alternative daily doses of inhaled corticosteroids to increase the effectiveness of anti-inflammatory therapy for this disease. Materials and methods: A complete comprehensive clinical-paraclinical examination of 65 schoolchildren with persistent asthma was conducted. According to the average daily dose of inhaled corticosteroids (ICS) the patients were divided into two clinical groups. The first (I) group consisted of 46 children who received ICS in the regimen of low-to-medium equipotent doses (253.95±9.98 μg per day), and the second (II) comparison group was formed of 19 patients who controlled the pBA using high doses of ICS (494.74±5.56 μg per day). Results: The patients of the І clinical group compared to patients of the ІІ group have a higher risk of the mild bronchial obstructive syndrome during asthma attacks. In assessing the level of control of persistent bronchial asthma using the CIA-scale, it was found that in II group cases of the controlled course of the disease were observed almost two times less than in children of the I group of comparison. In conducting spirography in children of comparison groups, it was shown that the ratio of indices of bronchospasm (FEV1/ FVC) was worse in patients receiving high doses of ICS. Conclusions: So, сharacteristic clinical feature of asthma controlled by high doses of ICS is more severe nature of bronchial obstructive syndrome during the period of exacerbation (OR=1.9-3.0). In the management of persistent bronchial asthma, the Gensler index which has high specificity (94.4%) and accuracy (92.2%) should be used for disease control verification.

scholarly journals Airway obstruction and chronic exertional dyspnoea in patients with persistent bronchial asthma

2000 ◽  
Vol 94 (7) ◽  
pp. 694-701 ◽  
Author(s):  
M. FILIPPELLI ◽  
F. PACINI ◽  
I. Romagnoli ◽  
E. ROSI ◽  
R. OTTANELLI ◽  
...  
Keyword(s):  
Airway Obstruction ◽  
Bronchial Asthma ◽  
Exertional Dyspnoea ◽  
Persistent Bronchial Asthma

scholarly journals Efektivitas Pemberian Oksigen Posisi Semi Fowler Dan Fowler Terhadap Perubahan Saturasi Pada Pasien Asma Bronkial Persisten Ringan

JKEP ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 31-43
Author(s):  
Syamsul Firdaus ◽  
Misbachul Munirul Ehwan ◽  
Agus Rachmadi
Keyword(s):  
Oxygen Saturation ◽  
Bronchial Asthma ◽  
Oxygen Therapy ◽  
Sampling Technique ◽  
T Test ◽  
Low Oxygen ◽  
Asthma Attack ◽  
Asthma Patients ◽  
The Difference ◽  
Persistent Bronchial Asthma

Mild persistent bronchial asthma is a chronic inflammatory airway that cause the low oxygen saturation value (91-95%). Administering oxygen therapy, setting the position of the semi fowler and fowler can reduce the risk of a decreased chest configuration. This research aims to assess the difference of effectiveness of administering oxygen at semi fowler with fowler position to the saturation changes in mild persistent bronchial asthma patients in Ratu Zalecha Martapura Hospital. This research method is quasy Experiment. The population research are all patients who experience mild persistent bronchial asthma attack, the sample of this research are 20 respondents with purposive sampling technique and analyzed with independent T test. The results is at semi fowler position the average of oxygen saturation before the treatment is 93.10%, after administering oxygen therapy with semi fowler position the average saturation is 98.00%. At the fowler position the average of oxygen saturation before the treatment is 92.60%, after administering oxygen therapy with fowler position the average saturation is 98.00%. The independent T-test result showed no difference of effectiveness of administering oxygen at semi fowler with fowler position to the saturation changes in mild persistent bronchial asthma patients,so teh patients can be given both positions.

scholarly journals Periostin as a promising biological marker of early recurrence of polyposis rhinosinusitis after surgical treatment

2021 ◽  
pp. 113-119
Author(s):  
V. M. Svistushkin ◽  
N. V. Chichkova ◽  
D. M. Pshonkina
Keyword(s):  
Surgical Treatment ◽  
Chronic Rhinosinusitis ◽  
Bronchial Asthma ◽  
Nasal Polyps ◽  
Biological Marker ◽  
Early Recurrence ◽  
Global Strategy ◽  
Nasal Secretion ◽  
High Concentration ◽  
Serum Periostin

Introduction. In spite of the numerous studies devoted to the issues of chronic rhinosinusitis with nasal polyps, the urgency of this problem remains due to the high incidence of the disease. The relapsing course of chronic rhinosinusitis with nasal polyps determines the uncontrolled course of bronchial asthma by patients with combined pathology. The main goal of case management of patients with chronic rhinosinusitis with nasal polyps is to achieve control over the polyposis process. It has been shown, that a promising direction is the study of biological markers. Goal. Study of the concentration of serum periostin in combination with serum eosinophilia and the number of eosinophils of the nasal secretion to predict early recurrence of chronic rhinosinusitis with nasal polyps after surgical treatment.Materials and methods. The study included 47 patients with a diagnosis of chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis with nasal polyps in combination with bronchial asthma. All patients underwent bilateral endoscopic polysinusotomy followed by case follow-up for a year. The diagnosis of bronchial asthma was made based on the diagnostic criteria defined in the Global Strategy for the Treatment and Prevention of Bronchial Asthma and in the Federal Clinical Guidelines for the Diagnosis and Treatment of Bronchial Asthma. All patients were consulted by a pulmonologist. Control examinations of patients were carried out every 3 months. All patients underwent a study of the concentration of periostin in the blood serum. Blood probe samples were taken before the start of treatment and after 12 months.Results and discussion. In the course of the study, was proved the relationship between a high concentration of serum periostin in combination with increased eosinophils of blood and nasal secretion with an early relapse of polyposis rhinosinusitis.Conclusions. An increased concentration of serum periostin before surgical treatment is a prognostically unfavorable factor for early recurrence of chronic rhinosinusitis with nasal polyps.

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