scholarly journals Author response: Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

2016 ◽  
Author(s):  
María Nicolás-Pérez ◽  
Franz Kuchling ◽  
Joaquín Letelier ◽  
Rocío Polvillo ◽  
Jochen Wittbrodt ◽  
...  
Keyword(s):  
Author Response ◽  
Response Analysis ◽  
Cellular Behavior ◽  
Optic Cup ◽  
Cytoskeletal Dynamics

scholarly journals Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
María Nicolás-Pérez ◽  
Franz Kuchling ◽  
Joaquín Letelier ◽  
Rocío Polvillo ◽  
Jochen Wittbrodt ◽  
...  
Keyword(s):  
Laser Cutting ◽  
Mechanical Tension ◽  
Cellular Behavior ◽  
Optic Cup ◽  
Tensile Forces ◽  
Cytoskeletal Dynamics ◽  
Cellular Machinery ◽  
Vertebrate Eye ◽  
Fast Oscillations ◽  
Developmental Window

Contractile actomyosin networks have been shown to power tissue morphogenesis. Although the basic cellular machinery generating mechanical tension appears largely conserved, tensions propagate in unique ways within each tissue. Here we use the vertebrate eye as a paradigm to investigate how tensions are generated and transmitted during the folding of a neuroepithelial layer. We record membrane pulsatile behavior and actomyosin dynamics during zebrafish optic cup morphogenesis by live imaging. We show that retinal neuroblasts undergo fast oscillations and that myosin condensation correlates with episodic contractions that progressively reduce basal feet area. Interference with lamc1 function impairs basal contractility and optic cup folding. Mapping of tensile forces by laser cutting uncover a developmental window in which local ablations trigger the displacement of the entire tissue. Our work shows that optic cup morphogenesis is driven by a constriction mechanism and indicates that supra-cellular transmission of mechanical tension depends on ECM attachment.

scholarly journals Author response: Analysis of SUMO1-conjugation at synapses

2017 ◽  
Author(s):  
James A Daniel ◽  
Benjamin H Cooper ◽  
Jorma J Palvimo ◽  
Fu-Ping Zhang ◽  
Nils Brose ◽  
...  
Keyword(s):  
Author Response ◽  
Response Analysis

scholarly journals Author response: Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

2020 ◽  
Author(s):  
Jordan F Hastings ◽  
Alvaro Gonzalez Rajal ◽  
Sharissa L Latham ◽  
Jeremy ZR Han ◽  
Rachael A McCloy ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Author Response ◽  
Response Analysis

scholarly journals Author response: Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

2019 ◽  
Author(s):  
Angela Schulz ◽  
Nicola Victoria Müller ◽  
Nina Anne van de Lest ◽  
Andreas Eisenreich ◽  
Martina Schmidbauer ◽  
...  
Keyword(s):  
Complex Trait ◽  
Kidney Damage ◽  
Author Response ◽  
Response Analysis ◽  
Rat Models ◽  
Genomic Architecture ◽  
Hypertensive Rat ◽  
Trait Locus

scholarly journals Author response: Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

2016 ◽  
Author(s):  
Mahdokht Kohansal-Nodehi ◽  
John JE Chua ◽  
Henning Urlaub ◽  
Reinhard Jahn ◽  
Dominika Czernik
Keyword(s):  
Protein Phosphorylation ◽  
Nerve Terminal ◽  
Active Zone ◽  
Author Response ◽  
Response Analysis
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