scholarly journals Author response: Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

2017 ◽  
Author(s):  
Hajime Fukui ◽  
Takahiro Miyazaki ◽  
Renee Wei-Yan Chow ◽  
Hiroyuki Ishikawa ◽  
Hiroyuki Nakajima ◽  
...  
Keyword(s):  
Author Response ◽  
Hippo Signaling ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Pole Cells ◽  
Anterior Lateral Plate Mesoderm

scholarly journals Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Hajime Fukui ◽  
Takahiro Miyazaki ◽  
Renee Wei-Yan Chow ◽  
Hiroyuki Ishikawa ◽  
Hiroyuki Nakajima ◽  
...  
Keyword(s):  
Cell Number ◽  
Bmp Signaling ◽  
Hippo Signaling ◽  
Lateral Plate Mesoderm ◽  
Cardiomyocyte Proliferation ◽  
Heart Tube ◽  
Lateral Plate ◽  
Large Tumor ◽  
Developmental Potential ◽  
Anterior Lateral Plate Mesoderm

The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart.

scholarly journals Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function

Development ◽  
2013 ◽  
Vol 140 (6) ◽  
pp. 1353-1363 ◽  
Author(s):  
B. Guner-Ataman ◽  
N. Paffett-Lugassy ◽  
M. S. Adams ◽  
K. R. Nevis ◽  
L. Jahangiri ◽  
...  
Keyword(s):  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Field Development ◽  
Second Heart Field ◽  
Heart Field ◽  
Anterior Lateral Plate Mesoderm

scholarly journals Endocardial differentiation in zebrafish occurs during early somitogenesis and is dependent on BMP and etv2 signalling

2019 ◽  
Author(s):  
Samuel J Capon ◽  
Kelly A Smith
Keyword(s):  
Vascular Endothelial ◽  
Lateral Plate Mesoderm ◽  
Loss Of Function ◽  
Lateral Plate ◽  
Molecular Identity ◽  
Cardiovascular Biology ◽  
Bmp Signalling ◽  
Anterior Lateral Plate Mesoderm ◽  
Function Models ◽  
Signalling Cascade

AbstractThe endocardium and adjacent vascular endothelial network share a number of molecular markers however there are distinct physiological functions of these tissues. What distinguishes these lineages on a molecular level remains an important, unanswered question in cardiovascular biology. We have identified the Gt(SAGFF27C); Tg(4xUAS:egfp) line as a marker of early endocardial development and used this line to examine endocardial differentiation. Our results show that the endocardium emerges from the anterior lateral plate mesoderm at the 8-somite stage (13 hpf). Analysis in a number of loss-of-function models showed that whilst nkx2.5, hand2 and tal1 loss-of-function have no effect on the endocardial progenitor domain, both etv2 loss-of-function and inhibition of BMP signalling reduce the endocardial domain. Furthermore, manipulating BMP signalling alters etv2 expression. Together, these results describe the onset of endocardial molecular identity and suggest a signalling cascade whereby BMP signalling acts upstream of etv2 to direct differentiation of endocardial progenitors.

Sign in / Sign up

Export Citation Format

Share Document