scholarly journals Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Maeva Dupont ◽  
Shanti Souriant ◽  
Luciana Balboa ◽  
Thien-Phong Vu Manh ◽  
Karine Pingris ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Risk Factor ◽  
Type I Interferon ◽  
Type I ◽  
Cell Transfer ◽  
Tunneling Nanotubes ◽  
Factors Associated ◽  
Tunneling Nanotube ◽  
Cell To Cell Transfer ◽  
Hiv 1

While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify molecular factors associated with TNT function, we performed a transcriptomic analysis in these macrophages, and revealed the up-regulation of Siglec-1 receptor. Siglec-1 expression depends on Mtb-induced production of type I interferon (IFN-I). In co-infected non-human primates, Siglec-1 is highly expressed by alveolar macrophages, whose abundance correlates with pathology and activation of IFN-I/STAT1 pathway. Siglec-1 localizes mainly on microtubule-containing TNT that are long and carry HIV-1 cargo. Siglec-1 depletion decreases TNT length, diminishes HIV-1 capture and cell-to-cell transfer, and abrogates the exacerbation of HIV-1 infection induced by Mtb. Altogether, we uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection and open new avenues to understand TNT biology.

scholarly journals Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

2019 ◽  
Author(s):  
Maeva Dupont ◽  
Shanti Souriant ◽  
Luciana Balboa ◽  
Thien-Phong Vu Manh ◽  
Karine Pingris ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Type I ◽  
Cell Transfer ◽  
Tunneling Nanotubes ◽  
Factors Associated ◽  
Lectin Receptor ◽  
Viral Spread ◽  
Tunneling Nanotube ◽  
Cell To Cell Transfer ◽  
Hiv 1

AbstractWhile tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis worsens HIV-1 pathogenesis remain poorly understood. Recently, we showed that HIV-1 infection and spread are exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify molecular factors associated with TNT function, we performed a transcriptomic analysis in these macrophages, and revealed the up-regulation of the lectin receptor Siglec-1. We demonstrate Siglec-1 expression depends on TB-mediated production of type I interferon. In co-infected non-human primates, Siglec-1 is highly expressed by alveolar macrophages, whose abundance correlates with pathology and activation of the type I interferon/STAT1 pathway. Intriguingly, Siglec-1 expression localizes exclusively on microtubule-containing TNT that are long and carry HIV-1 cargo. Siglec-1 depletion in macrophages decreases TNT length, diminishes HIV-1 capture and cell-to-cell transfer, and abrogates TB-driven exacerbation of HIV-1 infection. Altogether, we uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection, and its localization on TNT opens new avenues to understand cell-to-cell viral spread.

Type I Interferon as cardiovascular risk factor in systemic and cutaneous lupus erytheematosus: A systematic review

2021 ◽  
pp. 102794
Author(s):  
Chiara Kirchler ◽  
Emma Husar-Memmer ◽  
Klemens Rappersberger ◽  
Kylie Thaler ◽  
Ruth Fritsch-Stork
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factor ◽  
Type I Interferon ◽  
Type I ◽  
Cutaneous Lupus

scholarly journals Alteration of type I interferon response is associated with subclinical atherosclerosis in virologically suppressed HIV‐1‐infected male patients

2021 ◽  
Author(s):  
Letizia Santinelli ◽  
Gabriella De Girolamo ◽  
Cristian Borrazzo ◽  
Paolo Vassalini ◽  
Claudia Pinacchio ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Subclinical Atherosclerosis ◽  
Interferon Response ◽  
Type I ◽  
Infected Male ◽  
Male Patients ◽  
Hiv 1

scholarly journals A compartmentalized type I interferon response in the gut during chronic HIV-1 infection is associated with immunopathogenesis

AIDS ◽  
2018 ◽  
Vol 32 (12) ◽  
pp. 1599-1611 ◽  
Author(s):  
Stephanie M. Dillon ◽  
Kejun Guo ◽  
Gregory L. Austin ◽  
Sara Gianella ◽  
Phillip A. Engen ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Interferon Response ◽  
Type I ◽  
Hiv 1

scholarly journals Distinct efficacy of HIV-1 entry inhibitors to prevent cell-to-cell transfer of R5 and X4 viruses across a human placental trophoblast barrier in a reconstitution model in vitro

Retrovirology ◽  
2008 ◽  
Vol 5 (1) ◽  
pp. 31 ◽  
Author(s):  
Ahidjo Ayouba ◽  
Claude Cannou ◽  
Marie-Thérèse Nugeyre ◽  
Françoise Barré-Sinoussi ◽  
Elisabeth Menu
Keyword(s):  
Cell Transfer ◽  
Entry Inhibitors ◽  
Cell To Cell Transfer ◽  
Hiv 1

scholarly journals Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59194 ◽  
Author(s):  
Qian Chen ◽  
Sanjay Swaminathan ◽  
De Yang ◽  
Lue Dai ◽  
Hongyan Sui ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Type I Interferon ◽  
Potent Inhibitor ◽  
Type I ◽  
Interleukin 27 ◽  
Hiv 1

scholarly journals Hepatitis C virus drives increased type I interferon-associated impairments associated with fibrosis severity in antiretroviral treatment-treated HIV-1–hepatitis C virus-coinfected individuals

AIDS ◽  
2017 ◽  
Vol 31 (9) ◽  
pp. 1223-1234 ◽  
Author(s):  
Morgane Griesbeck ◽  
Marc-Antoine Valantin ◽  
Karine Lacombe ◽  
Assia Samri-Hassimi ◽  
Julie Bottero ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiretroviral Treatment ◽  
Type I Interferon ◽  
Type I ◽  
Hiv 1
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