scholarly journals Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Sebastian Hückesfeld ◽  
Philipp Schlegel ◽  
Anton Miroschnikow ◽  
Andreas Schoofs ◽  
Ingo Zinke ◽  
...  
Keyword(s):  
Network Architecture ◽  
Network Modeling ◽  
Neurosecretory Cells ◽  
Synaptic Inputs ◽  
Diuretic Hormone ◽  
Sensory Pathways ◽  
Transmission Electron ◽  
Target Organs ◽  
Endocrine Organs ◽  
The Brain

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide-responsive network that acts on a specific set of neurosecretory cells and that includes those expressing corazonin (Crz) and diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.

scholarly journals Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

2020 ◽  
Author(s):  
Sebastian Hückesfeld ◽  
Philipp Schlegel ◽  
Anton Miroschnikow ◽  
Andreas Schoofs ◽  
Ingo Zinke ◽  
...  
Keyword(s):  
Network Architecture ◽  
Network Modeling ◽  
Neurosecretory Cells ◽  
Synaptic Inputs ◽  
Diuretic Hormone ◽  
Sensory Pathways ◽  
Transmission Electron ◽  
Target Organs ◽  
Endocrine Organs ◽  
The Brain

AbstractNeuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the periphery, the synaptic inputs onto these neuroendocrine outputs in the brain are less well understood. Here, we use the transmission electron microscopy reconstruction of a whole central nervous system in the Drosophila larva to elucidate the sensory pathways and the interneurons that provide synaptic input to the neurosecretory cells projecting to the endocrine organs. Predicted by network modeling, we also identify a new carbon dioxide responsive network that acts on a specific set of neurosecretory cells and which include those expressing Corazonin (Crz) and Diuretic hormone 44 (DH44) neuropeptides. Our analysis reveals a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways that converge onto distinct combinations of neuroendocrine outputs.

THE NEUROENDOCRINE ORGANS OF LARVAE OF NEODIPRION LECONTEI, N. SWAINEI, AND DIPRION HERCYNIAE (HYMENOPTERA: DIPRIONIDAE)

1973 ◽  
Vol 105 (5) ◽  
pp. 725-731 ◽  
Author(s):  
C. F. Hinks
Keyword(s):  
Neurosecretory Cells ◽  
Corpus Allatum ◽  
Single Pair ◽  
Corpora Cardiaca ◽  
Neodiprion Lecontei ◽  
Lateral Organs ◽  
Segmental Nerve ◽  
Endocrine Organs ◽  
Neuroendocrine Organs ◽  
The Brain

AbstractLarvae and eonymphs of the diprionid sawflies Neodiprion lecontei (Fitch), Neodiprion swainei Midd., and Diprion hercyniae (Htg.) were dissected and stained to demonstrate the nervous system and endocrine organs. Morphologically and anatomically the endocrine organs in both larvae and eonymphs of all three species are very similar. The cephalic structures comprise lateral and medial neurosecretory cells in the brain which discharge their secretions through a single pair of nerves (NCC) to the corpora cardiaca. The NCC divide before they enter the corpora cardiaca sending a branch to the corresponding corpus allatum. No other nervous connections with these organs are apparent.Paired neurohaemal organs occur in each thoracic segment, forming distinct dilations on slender nerves arising from the ventral cord connectives. They receive secretions from groups of lateral neurosecretory cells in the thoracic ganglia.Each abdominal ganglion has three neurohaemal organs associated with it, a single small spherical structure antero-medially, and paired lateral organs of a diffuse structure, overlying the base of each segmental nerve. They are less conspicuous than the thoracic organs and have different staining properties.

Activity of the Brain/Corpora Cardiaca System during Pupal Diapause ‘Break’ in Mimas tiliae (Lepidoptera)

1958 ◽  
Vol s3-99 (45) ◽  
pp. 73-88
Author(s):  
K. C. HIGHNAM
Keyword(s):  
Low Temperature ◽  
Secretory Activity ◽  
Neurosecretory Cells ◽  
Corpora Cardiaca ◽  
Endocrine Organs ◽  
Pupal Diapause ◽  
Diapause Development ◽  
Histological Results ◽  
Further Development ◽  
The Brain

Pupal diapause in Mimas tiliae can be terminated by keeping the pupa for at least 4 weeks at 3° C. The adult emerges about 15 days after transfer to 25° C. Histological examination shows that the neurosecretory cells in the brain are inactive in the diapausing pupa, but they elaborate intracellular material during the first 3 weeks at 3° C. The material is passed to the corpora cardiaca. The neurosecretory cells are again inactive by the end of the low-temperature period. The brain/cardiaca system shows little sign of secretory activity during the subsequent period at 25° C. The corpora cardiaca undergo phagocytosis and reorganization during this time. This suggests that conditions for further development are established by the end of the low-temperature period. This hypothesis is supported by the fact that development of the non-endocrine organs begins immediately the pupa is transferred to 25° C after 4 weeks at 3° C. Extirpation and implantation experiments involving the brain, with and without its associated corpora cardiaca, support the histological results, indicating that the brain is necessary for diapause development at 3° C and that the corpora cardiaca are involved in the release of the brain factor.

Application of Scanning Electron Microscopy to Medical Research

1969 ◽  
Vol 27 ◽  
pp. 12-13
Author(s):  
J. D. Hutchison
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Medical Research ◽  
Prosthetic Heart Valve ◽  
School Of Medicine ◽  
Transmission Electron ◽  
Definition Of ◽  
Mechanism Of Failure ◽  
The Brain ◽  
Scanning Electron

When the transmission electron microscope was commercially introduced a few years ago, it was heralded as one of the most significant aids to medical research of the century. It continues to occupy that niche; however, the scanning electron microscope is gaining rapidly in relative importance as it fills the gap between conventional optical microscopy and transmission electron microscopy.IBM Boulder is conducting three major programs in cooperation with the Colorado School of Medicine. These are the study of the mechanism of failure of the prosthetic heart valve, the study of the ultrastructure of lung tissue, and the definition of the function of the cilia of the ventricular ependyma of the brain.

The brain structure and neurosecretory cells of noctuid moth Anadevidia peponis: Noctuidae

1990 ◽  
Vol 48 (3) ◽  
pp. 436-437
Author(s):  
M. Sato ◽  
Y. Ogawa ◽  
M. Sasaki ◽  
T. Matsuo
Keyword(s):  
Biological Clock ◽  
Virgin Female ◽  
Basic Structure ◽  
Fixed Time ◽  
Neurosecretory Cells ◽  
Nerve Cells ◽  
Noctuid Moth ◽  
The Right ◽  
20 Nm ◽  
The Brain

A virgin female of the noctuid moth, a kind of noctuidae that eats cucumis, etc. performs calling at a fixed time of each day, depending on the length of a day. The photoreceptors that induce this calling are located around the neurosecretory cells (NSC) in the central portion of the protocerebrum. Besides, it is considered that the female’s biological clock is located also in the cerebral lobe. In order to elucidate the calling and the function of the biological clock, it is necessary to clarify the basic structure of the brain. The observation results of 12 or 30 day-old noctuid moths showed that their brains are basically composed of an outer and an inner portion-neural lamella (about 2.5 μm) of collagen fibril and perineurium cells. Furthermore, nerve cells surround the cerebral lobes, in which NSCs, mushroom bodies, and central nerve cells, etc. are observed. The NSCs are large-sized (20 to 30 μm dia.) cells, which are located in the pons intercerebralis of the head section and at the rear of the mushroom body (two each on the right and left). Furthermore, the cells were classified into two types: one having many free ribosoms 15 to 20 nm in dia. and the other having granules 150 to 350 nm in dia. (Fig. 1).

HISTOMORPHOLOGICAL CHANGES IN THE BRAIN IN RELATION TO OVARIAN CYCLE OF FRESHWATER CRAB, BARYTELPHUSA CUNICULARIS

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
C.A. JAWALE
Keyword(s):  
Staining Intensity ◽  
Neurosecretory Cells ◽  
Ovarian Cycle ◽  
Secretory Product ◽  
Freshwater Crab ◽  
Intensity Index ◽  
Cytoplasmic Material ◽  
Histomorphological Changes ◽  
Cyclic Changes ◽  
The Brain

Ovarian maturation by neurosecretory cells in the brain of freshwater crab, Barytelphusa cunicularis have been examined. The histological scrutiny of the brain of Barytelphusa cunicularis related with three types (A, B and C) of neurosecretory cells, which are classified on the basis of size, shape and tinctorial characters. All these types of cells marked annual cyclic changes of cytoplasmic material in association with ovarian cycle. The activity of these cells has been correlated with the ovarian cycle. They are distinguishable by their size, nature locations, shape, nucleus position, cell measure and the secretory product in the cytoplasm. The result indicates that the neurosecretory A, B and C cells of the brain seen involved in the process of mating ovulation. The neurosecretory materials staining intensity index of these cells is described.

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility

2021 ◽  
Author(s):  
Christopher L. Hartl ◽  
Gokul Ramaswami ◽  
William G. Pembroke ◽  
Sandrine Muller ◽  
Greta Pintacuda ◽  
...  
Keyword(s):  
Network Architecture ◽  
Disease Susceptibility ◽  
Coexpression Network ◽  
The Brain

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

2019 ◽  
Vol 128 (06/07) ◽  
pp. 388-394
Author(s):  
Helge Müller-Fielitz ◽  
Markus Schwaninger
Keyword(s):  
Energy Homeostasis ◽  
Genetic Manipulation ◽  
Heart Function ◽  
Feedback Regulation ◽  
Target Organs ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Hpt Axis ◽  
The Brain

AbstractThyroid hormone (TH) regulation is important for development, energy homeostasis, heart function, and bone formation. To control the effects of TH in target organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific availability of TH are highly regulated by negative feedback. To exert a central feedback, TH must enter the brain via specific transport mechanisms and cross the blood-brain barrier. Here, tanycytes, which are located in the ventral walls of the 3rd ventricle in the mediobasal hypothalamus (MBH), function as gatekeepers. Tanycytes are able to transport, sense, and modify the release of hormones of the HPT axis and are involved in feedback regulation. In this review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone (TRH) release and review available genetic tools to investigate the physiological functions of these cells.

Neurosecretory Cells in the Brain of the Larva of Lucilia caesar L.

Nature ◽  
1957 ◽  
Vol 179 (4553) ◽  
pp. 257-258 ◽  
Author(s):  
ALASTAIR FRASER
Keyword(s):  
Neurosecretory Cells ◽  
The Brain

scholarly journals Recurrent Multi-Fiber Network for 3D MRI Brain Tumor Segmentation

Symmetry ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 320
Author(s):  
Yue Zhao ◽  
Xiaoqiang Ren ◽  
Kun Hou ◽  
Wentao Li
Keyword(s):  
Brain Tumor ◽  
Network Architecture ◽  
Contextual Information ◽  
Computational Cost ◽  
Disease Diagnosis ◽  
Tumor Segmentation ◽  
Brain Tumor Segmentation ◽  
Fiber Network ◽  
3D Network ◽  
The Brain

Automated brain tumor segmentation based on 3D magnetic resonance imaging (MRI) is critical to disease diagnosis. Moreover, robust and accurate achieving automatic extraction of brain tumor is a big challenge because of the inherent heterogeneity of the tumor structure. In this paper, we present an efficient semantic segmentation 3D recurrent multi-fiber network (RMFNet), which is based on encoder–decoder architecture to segment the brain tumor accurately. 3D RMFNet is applied in our paper to solve the problem of brain tumor segmentation, including a 3D recurrent unit and 3D multi-fiber unit. First of all, we propose that recurrent units segment brain tumors by connecting recurrent units and convolutional layers. This quality enhances the model’s ability to integrate contextual information and is of great significance to enhance the contextual information. Then, a 3D multi-fiber unit is added to the overall network to solve the high computational cost caused by the use of a 3D network architecture to capture local features. 3D RMFNet combines both advantages from a 3D recurrent unit and 3D multi-fiber unit. Extensive experiments on the Brain Tumor Segmentation (BraTS) 2018 challenge dataset show that our RMFNet remarkably outperforms state-of-the-art methods, and achieves average Dice scores of 89.62%, 83.65% and 78.72% for the whole tumor, tumor core and enhancing tumor, respectively. The experimental results prove our architecture to be an efficient tool for brain tumor segmentation accurately.

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