Variations in Progression and Regression of Precancerous Lesions of the Uterine Cervix on Cytology Testing Among Women of Different Races

Objective: To evaluate the clinical accuracy of Hepika test to identify cancer/precancerous lesions of the uterine cervix. Materials and Methods: A multicentre retrospective study was carried out in 2018 and included 330 liquid-based cytology samples from three Italian centres of women aged 25–64 who had been tested for the human papillomavirus (HPV) and whose histology or follow-up outcome was known. Hepika is an enzyme-linked immunosorbent assay (ELISA) targeting the protein complexes E6#p53 and E7#pRb. After excluding samples without sufficient residual material, the clinical accuracy of Hepika test was evaluated in 274 samples: adenocarcinoma (ADC) (4), squamous cell carcinoma (SCC) (7), adenocarcinoma in situ (AIS) (1), cervical intraepithelial neoplasia (CIN) grade 3 (60), CIN2 (51), CIN1 (34), and negative histology (117). Association, sensitivity, and specificity for carcinoma, CIN3+ and CIN2+ are reported. Results: Positive Hepika test was associated with a high probability of carcinoma (odds ratio (DOR) = 33.68, 95% confidence interval (CI) 7.0–163.1); sensitivity was 81.8%, specificity, 88.2%. A positive Hepika test showed a weaker association with CIN3+ lesions (DOR = 3.5; 95% CI 1.75–6.99) and lower sensitivity (27.8%). Conclusion: The Hepika test was found to be an accurate biomarker for HPV-induced cervical carcinoma. Population-based prospective studies are needed to confirm the clinical usefulness of the Hepika test in the differential diagnosis of HPV-induced invasive lesions.

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High prevalence of serum antibodies to Ras and type 16 E4 proteins of human papillomavirus in patients with precancerous lesions of the uterine cervix

Archives of Virology ◽

10.1007/s007050050050 ◽

2000 ◽

Vol 145 (3) ◽

pp. 603-623 ◽

Cited By ~ 6

Author(s):

A. Pedroza-Saavedra ◽

A. Cruz ◽

F. Esquivel ◽

F. De La Torre ◽

J. Berumen ◽

...

Keyword(s):

Human Papillomavirus ◽

Uterine Cervix ◽

Precancerous Lesions ◽

Serum Antibodies ◽

High Prevalence

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MobileNetV2 Ensemble for Cervical Precancerous Lesions Classification

Processes ◽

10.3390/pr8050595 ◽

2020 ◽

Vol 8 (5) ◽

pp. 595 ◽

Cited By ~ 1

Author(s):

Cătălin Buiu ◽

Vlad-Rareş Dănăilă ◽

Cristina Nicoleta Răduţă

Keyword(s):

Uterine Cervix ◽

Precancerous Lesions ◽

Binary Classification ◽

The United States ◽

Medical Procedure ◽

Medical Doctors ◽

Analysis Framework ◽

Cervical Precancerous Lesions ◽

Classification Tasks

Women’s cancers remain a major challenge for many health systems. Between 1991 and 2017, the death rate for all major cancers fell continuously in the United States, excluding uterine cervix and uterine corpus cancers. Together with HPV (Human Papillomavirus) testing and cytology, colposcopy has played a central role in cervical cancer screening. This medical procedure allows physicians to view the cervix at a magnification of up to 10%. This paper presents an automated colposcopy image analysis framework for the classification of precancerous and cancerous lesions of the uterine cervix. This framework is based on an ensemble of MobileNetV2 networks. Our experimental results show that this method achieves accuracies of 83.33% and 91.66% on the four-class and binary classification tasks, respectively. These results are promising for the future use of automatic classification methods based on deep learning as tools to support medical doctors.

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Identifying early cancer of the uterine cervix - a look at the precursor lesions: literature integrative review

Revista de Enfermagem UFPE on line ◽

10.5205/reuol.1262-12560-1-le.0503201133 ◽

2011 ◽

Vol 5 (3) ◽

pp. 812

Author(s):

Rosana Oliveira Melo ◽

Regina Mendonça Lopes ◽

Rita Rocha Moreira

Keyword(s):

Early Diagnosis ◽

Uterine Cervix ◽

Precancerous Lesions ◽

Intraepithelial Neoplasia ◽

Service Access ◽

Precursor Lesions ◽

Treatment Access ◽

Calidad De Vida ◽

Factores De Riesgo ◽

Las Mujeres

ABSTRACTObjective: presenting a literature review reflects on the prevention of precursor lesions for cancer of the uterine cervix. Method: this is about a literature integrative study. Were used in this review: books (6), summaries of theses (5) and thesis (1) articles (7), as well as national and international publications in terms of health print and online. These materials were read and analyzed between April 2009 and July 2010. Results: upon reading and cataloging the data were organized into analytical categories: identification of risk factors, prevention, early diagnosis and appropriate treatment, access to services, recognition of the subjectivity of women with precancerous lesions of the cervix. Conclusion: this study allowed reflection on the diagnosis and treatment of precursor lesions demonstrating the importance of a closer look at prevention in order to improve service access, dialogue with health professionals, as well as the quality of life and longevity of women with these lesions. Descriptors: nursing; women's health; cervix neoplasms prevention; cervical intraepithelial neoplasia; early diagnosis. RESUMOObjetivo: apresentar revisão da literatura sobre a importância do diagnóstico precoce das lesões precursoras para prevenção do câncer do colo do útero. Método: utilizou- se a pesquisa bibliográfica. Foram utilizados nesta revisão: livros (6), resumos de dissertações (5) e tese (1), artigos (7), além de publicações nacionais e internacionais da saúde nas modalidades impressa e online. Estes materiais foram lidos e analisados entre abril de 2009 a julho de 2010. Resultados: após a catalogação e leitura, os dados encontrados foram organizados em eixos analíticos: identificação dos fatores de risco, a prevenção, diagnóstico precoce e tratamento adequado, acesso aos serviços, valorização da subjetividade das mulheres com lesões precursoras de câncer do colo do útero. Conclusão: este estudo permitiu reflexões sobre o diagnóstico e a terapêutica das lesões precursoras demonstrando a relevância de um olhar atento para a prevenção na perspectiva de melhorar o acesso ao serviço, o diálogo com os profissionais de saúde, bem como, a qualidade de vida e longevidade das mulheres portadoras destas lesões. Descritores: enfermagem; saúde da mulher; prevenção de câncer de colo uterino; neoplasia intra-epitelial cervical; diagnóstico precoce. RESUMEN Objetivo: presentar una revisión de la literatura con el objetivo reflexionar sobre la prevención de las lesiones precursoras de cáncer de cuello uterino. Método: se utilizó la búsqueda bibliográfica. Se utilizaron en esta revisión: los libros (6), resúmenes de tesis (5) y la tesis (1) artículos (7), así como publicaciones nacionales e internacionales en materia de salud y de impresión en línea. Estos materiales fueron leídos y analizados entre abril de 2009 y julio de 2010. Resultados: Al momento de la lectura y la catalogación de los datos fueron organizados en categorías de análisis: la identificación de factores de riesgo, prevención, diagnóstico precoz y un tratamiento adecuado, el acceso a los servicios, el reconocimiento de la subjetividad de las mujeres con lesiones precancerosas del cuello uterino. Conclusión: este estudio permitió la reflexión sobre el diagnóstico y tratamiento de lesiones precursoras que demuestra la importancia de una mirada más cercana a la prevención con el fin de mejorar el acceso de servicio, el diálogo con los profesionales de la salud, así como la calidad de vida y longevidad de las mujeres con estas lesiones. Descriptores: enfermería, salud de la mujer; prevención de cáncer de cuello uterino; neoplasia intraepitelial del cuello uterino; diagnóstico precoz.

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