scholarly journals Comparison of Breast Milk Minerals’ Concentration between Gestational Diabetes Mothers and Healthy Mothers

2021 ◽  
Vol 23 (3) ◽  
pp. 180-187
Author(s):  
Deulle Min ◽  
Seungmi Park
Keyword(s):  
Breast Milk ◽  
Gestational Diabetes ◽  
Milk Minerals

scholarly journals Women with gestational diabetes mellitus (GDM) have breast milk with lower concentration of docosahexaenoic acid (DHA) compared to women without GDM

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Julissa Marisel Salguero ◽  
Emily Fontenot ◽  
Alicia Page ◽  
Holiday Durham ◽  
Olivia Servan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Breast Milk ◽  
Docosahexaenoic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

scholarly journals Association between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study

Foods ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 659 ◽  
Author(s):  
Cristina Sánchez ◽  
Cristina Fente ◽  
Rocío Barreiro ◽  
Olga López-Racamonde ◽  
Alberto Cepeda ◽  
...  
Keyword(s):  
Breast Milk ◽  
Dietary Patterns ◽  
Mineral Content ◽  
Linear Regression Analysis ◽  
Essential Elements ◽  
Multivariate Linear Regression Analysis ◽  
Diet Pattern ◽  
Spanish Women ◽  
Northwestern Spain ◽  
Milk Minerals

The composition of breast milk is influenced by many factors, some of which dependent on the mother and others on the child. Changes in lactation and other factors depending on the mother’s physiology and anthropometric characteristics, as well as her nutritional status and diet, are of key importance. Breast milk minerals have been extensively studied with highly uneven results. In this work, a comparison will made with data across the world. To understand the factors that might explain the disparity, several minerals (Na, K, Ca, P, Mg, Fe, Se and I) have been analyzed using ICP-MS in a set of human milk samples (n = 75). The samples had an identical geographical origin (Galicia, in northwestern Spain) but different lactation circumstances, including maternal anthropometric data, lactating time, newborn sex and maternal adherence to healthy dietary patterns (Mediterranean Diet, MD, or Atlantic Diet, AD). The required concentrations of essential elements reported in the literature are similar to those found in these Spanish women. A univariate approach revealed that factors such as lactating time, body mass index (BMI) and newborn sex have a significant influence in breastmilk mineral content. According to multivariate linear regression analysis, minerals in milk are particularly associated with lactating time, but also with newborn sex, maternal BMI, age and diet pattern in some cases. More precisely, these results suggest that the iron and selenium concentrations in the milk of Galician donors may be positively influenced by maternal adherence to AD and MD, respectively.

Association of chemerin gene promoter methylation in maternal blood and breast milk during gestational diabetes

2021 ◽  
pp. 1-7
Author(s):  
Syeda Sadia Fatima ◽  
Rehana Rehman ◽  
Jibran Sualeh Muhammad ◽  
Russell Martins ◽  
Nuruddin Mohammed ◽  
...  
Keyword(s):  
Breast Milk ◽  
Gestational Diabetes ◽  
Cord Blood ◽  
Early Life ◽  
Gene Promoter ◽  
Maternal Blood ◽  
Maternal Plasma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mature Milk ◽  
Fetal Cord Blood

Abstract The intrauterine environment and early-life nutrition are regulated by maternal biomarkers in the blood and breast milk. We aimed to explore epigenetic modifications that may contribute to differential chemerin expression in maternal plasma, colostrum, and breast milk and find its association with fetal cord blood and infant weight at 6 weeks postpartum. Thirty-three gestational diabetes mellitus (GDM) mothers and 33 normoglycemic mothers (NGT) were recruited. Two maternal blood samples (28th week of gestation and 6 weeks postpartum), cord blood, colostrum, and mature milk were collected. Methylation-specific polymerase chain reaction and enzyme-linked immunosorbent assay were conducted. The weight of the babies was measured at birth and 6 weeks postpartum. Serum chemerin levels at the 28th gestational week and 6 weeks postpartum were significantly lower for the NGT group as compared to the GDM group; (P < 0.05). Higher colostrum chemerin concentrations were observed in the GDM group and remained elevated in mature milk as compared to NGT (P < 0.05). Colostrum and breast milk chemerin levels showed an independent association with infant weight at 6 weeks postpartum (r = 0.270; P = 0.034) (r = 0.464; P < 0.001). Forty percent GDM mothers expressed unmethylated chemerin reflecting increased chemerin concentration in the maternal blood. This pattern was also observed in newborn cord blood where 52% of samples showed unmethylated chemerin in contrast to none in babies born to normoglycemic mothers. The results of this study highlight the critical importance of altered chemerin regulation in gestational diabetic mothers and its effect during early life period and suggest a possible role in contributing to childhood obesity.

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