scholarly journals Epidemiological evidence on extra-medical use of prescription pain relievers: transitions from newly incident use to dependence among 12–21 year olds in the United States using meta-analysis, 2002–13

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e1340 ◽  
Author(s):  
Maria A. Parker ◽  
James C. Anthony

Background.When 12-to-21-year-olds start using prescription pain relievers extra-medically, some of them transition into opioid dependence within 12 months after such use. Our main aim for this epidemiological research on 12-to-21-year-olds in the United States (US) is to estimate the risk of becoming a newly incident case of opioid dependence within 12 months after onset of using prescription pain relievers extra-medically (EMPPR).Methods.Meta-analyses from multiple independent replication samples now are possible, based upon nationally representative survey samples of US adolescents age 12–21 years. All 12-to-21-year-olds were sampled and recruited for the US National Surveys on Drug Use and Health, with standardized assessments of EMPPR use and opioid dependence (NSDUH, 2002–2013).Results.Peak risk for a transition from start of EMPPR use to opioid dependence within 12 months is seen at mid-adolescence among 14-to-15-year-olds (6.3%, 8.7% per year), somewhat earlier than peak risk for starting EMPPR use (seen for 16-to-19-year-olds at 4.1%, 5.9% per year). Applied to 12-to-21-year-olds in the US between 2002–2013, an estimated 8 million started using PPR extra-medically. Each year, roughly 42,000 to 58,000 transitioned into opioid dependence within 12 months after onset of such use.Discussion.These epidemiological estimates for the US in recent years teach us to expect one transition into adolescent-onset opioid dependence within 12 months for every 11–16 newly incident EMPPR users, yielding perhaps 120 newly incident opioid dependent cases in need of practitioner attention or treatment services, each day of each year. This evidence can be used to motivate more effective public health prevention, outreach, and early intervention programs as might prevent or delay occurrence of EMPPR use and opioid dependence.

2017 ◽  
Vol 8 (8) ◽  
pp. 904-909 ◽  
Author(s):  
Takeshi Hamamura ◽  
Berlian Gressy Septarini

Self-esteem is increasing in the United States according to temporal meta-analyses of the Rosenberg Self-Esteem Scale. However, it remains unclear whether this trend reflects broad social ecological shifts toward urban, affluent, and technologically advanced or a unique cultural history. A temporal meta-analysis of self-esteem was conducted in Australia. Australia shares social ecological and cultural similarities with the United States. On the other hand, Australian culture is horizontally individualistic and places a stronger emphasis on self-other equality compared to American culture. For this reason, the strengthening norm of positive self-esteem found in the United States may not be evident in Australia. Consistent with this possibility, the findings indicated that self-esteem among Australian high school students, university students, and community participants did not change between 1978 and 2014.


2011 ◽  
Vol 101 (9) ◽  
pp. 1122-1132 ◽  
Author(s):  
P. A. Paul ◽  
L. V. Madden ◽  
C. A. Bradley ◽  
A. E. Robertson ◽  
G. P. Munkvold ◽  
...  

The use of foliar fungicides on field corn has increased greatly over the past 5 years in the United States in an attempt to increase yields, despite limited evidence that use of the fungicides is consistently profitable. To assess the value of using fungicides in grain corn production, random-effects meta-analyses were performed on results from foliar fungicide experiments conducted during 2002 to 2009 in 14 states across the United States to determine the mean yield response to the fungicides azoxystrobin, pyraclostrobin, propiconazole + trifloxystrobin, and propiconazole + azoxystrobin. For all fungicides, the yield difference between treated and nontreated plots was highly variable among studies. All four fungicides resulted in a significant mean yield increase relative to the nontreated plots (P < 0.05). Mean yield difference was highest for propiconazole + trifloxystrobin (390 kg/ha), followed by propiconazole + azoxystrobin (331 kg/ha) and pyraclostrobin (256 kg/ha), and lowest for azoxystrobin (230 kg/ha). Baseline yield (mean yield in the nontreated plots) had a significant effect on yield for propiconazole + azoxystrobin (P < 0.05), whereas baseline foliar disease severity (mean severity in the nontreated plots) significantly affected the yield response to pyraclostrobin, propiconazole + trifloxystrobin, and propiconazole + azoxystrobin but not to azoxystrobin. Mean yield difference was generally higher in the lowest yield and higher disease severity categories than in the highest yield and lower disease categories. The probability of failing to recover the fungicide application cost (ploss) also was estimated for a range of grain corn prices and application costs. At the 10-year average corn grain price of $0.12/kg ($2.97/bushel) and application costs of $40 to 95/ha, ploss for disease severity <5% was 0.55 to 0.98 for pyraclostrobin, 0.62 to 0.93 for propiconazole + trifloxystrobin, 0.58 to 0.89 for propiconazole + azoxystrobin, and 0.91 to 0.99 for azoxystrobin. When disease severity was >5%, the corresponding probabilities were 0.36 to 95, 0.25 to 0.69, 0.25 to 0.64, and 0.37 to 0.98 for the four fungicides. In conclusion, the high ploss values found in most scenarios suggest that the use of these foliar fungicides is unlikely to be profitable when foliar disease severity is low and yield expectation is high.


2022 ◽  
Author(s):  
Sam van Noort

American geopolitical power partly relies on foreign public support for its leadership. Pundits worry that this support is evaporating now that the United States—which claims to be the world’s beacon of democracy—has itself experienced democratic back- sliding. I provide the first natural experimental test of this hypothesis by exploiting that the January 6 insurrection of the US Capitol unexpectedly occurred while Gallup was conducting nationally-representative surveys in India, Indonesia, Malaysia, Romania, and Vietnam. Because Gallup uses random digit dialing I can identify the effect by comparing US leadership approval among respondents that were interviewed just before, and just after, January 6, 2021. I find that the insurrection had no effect on US approval. If even a violent attempt to overturn a free and fair election does not affect US approval abroad it is unlikely that any other domestic anti-democratic event will.


Author(s):  
Arie Glebbeek ◽  
Els Sol

In spite of a much improved labor market, the outcome of a leading evaluation report on reemployment programs in the Netherlands turned out negative. This result might be due to limitations of the evaluation method used by the researchers, who had to content themselves with a nonexperimental approach. Currently, for many evaluation researchers, the experimental method stands out as the superior design, especially when combined with a meta-analysis over several trials. We show, however, that experimental evaluations do not solve the uncertainties in this field. Meta-analyses of evaluation studies in Europe and the United States produced strikingly mixed results. Efforts to trace their diversity to variations in reemployment programs have not been very successful. This is mainly because of the “black box character” of many experimental evaluations, which offer little information about the content of the programs. Following “realistic evaluation,” we argue for a focus on the theories behind these programs in evaluation research. To this end, reemployment services are depicted in twelve core (mediating) mechanisms.


2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae Eui Soh ◽  
Mohammed A. Khan ◽  
William W. Thompson ◽  
Lauren Canary ◽  
Claudia J. Vellozzi ◽  
...  

ObjectiveUsing a large nationally representative dataset, we estimated the prevalence of self-reported hepatitis C testing among individuals who were recommended to be tested (i.e., baby boomer cohort born between 1945 and 1965) by the CDC and United States Preventive Services Task Force.IntroductionHepatitis C virus (HCV) infection is the most common blood-borne disease in the US and the leading cause of liver-related morbidity and mortality. Approximately 3.5 million individuals in the US were estimated to have been living with hepatitis C in 2010 and approximately half of them were unaware that they were infected. Among HCV infected individuals, those born between 1945 and 1965 (usually referred to as the baby boomer cohort) represents approximately 75% of current cases. Because of the substantial burden of disease among this age group, CDC expanded its existing hepatitis C risk-based testing recommendations to include a one-time HCV antibody test for all persons born between 1945 and 1965. The United States Preventive Services Task Force (USPSTF) subsequently made the same recommendation in June 2013.DescriptionMethodsThe following question "Have you ever had a blood test for hepatitis C?" has been administered annually from 2013 through 2017 on the National Health Interview Survey (NHIS). The NHIS is a nationally representative cross-sectional face-to-face household interview of civilian noninstitutionalized individuals in the U.S. The NHIS survey uses a complex multistage probability design that includes stratification, clustering, and oversampling. We estimated the prevalence of hepatitis C testing for adults in the US during the study period from 2013 to 2017. In addition, we carried out stratified analyses comparing those with private insurance to those who did not have private insurance. We reported weighted estimates taking into account the NHIS survey design. The R statistical software (R Core Team, 2018) was used to estimate weighted prevalence estimates for hepatitis C testing.ResultsDuring the study period from 2013-2017, there were 148,674 adults who responded to the ever tested for hepatitis C question. In addition, 33.56% of these individuals were born between 1945 and 1965; among all adults, the weighted percentage of individuals that responded yes they had received a hepatitis C screening test was 12.82% (95% CI: 12.54-13.10%) while for baby boomers the estimate was 13.93% (95% CI: 13.51-14.35%).Figure 1 presents the annual trend in the hepatitis C test prevalence over the study period by birth cohorts. For both cohorts, there were significant increases over time in hepatitis C testing prevalence. The two trend lines began to diverge in 2015 with the baby boomer cohort reporting higher rates of hepatitis C testing. For the baby boomer cohort, there was also a substantial increase in reported hepatitis C testing in 2017 relative to 2016. Similar trends were found for the samples when we restricted the sample to only those with private insurance. Compared to the people with private insurance, the baby boomers with 'Non-private’ insurance, including Medicaid, Medicare, or military- government sponsored insurances, reported higher rates of testing.ConclusionAcross the five-year period from 2013 through 2017, we found increasing rates of self-reported hepatitis C testing among non-institutionalized U.S. adults. For the baby boomer cohort, we saw a substantial increase in testing in 2017, which was likely due in part, to increased awareness among both physicians and patients of the CDC and USPSTF recommendation to have all baby boomers tested. Efforts to increase the awareness of these recommendations should continue. Additional targeted promotions among hard to reach populations should also be considered.How the Moderator Intends to Engage the Audience in Discussions on the TopicThis panel will discuss strengths and weaknesses for monitoring hepatitis C testing using alternative data sources including self-reported data, insurance claims data, and laboratory testing data. 


2013 ◽  
Vol 103 (4) ◽  
pp. 1109-1137 ◽  
Author(s):  
Jason Long ◽  
Joseph Ferrie

The US tolerates more inequality than Europe and believes its economic mobility is greater than Europe's, though they had roughly equal rates of intergenerational occupational mobility in the late twentieth century. We extend this comparison into the nineteenth century using 10,000 nationally-representative British and US fathers and sons. The US was more mobile than Britain through 1900, so in the experience of those who created the US welfare state in the 1930s, the US had indeed been “exceptional.” The US mobility lead over Britain was erased by the 1950s, as US mobility fell from its nineteenth century levels. (JEL J62, N31, N32, N33, N34)


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