Soybean rust in Brazil is currently controlled with several commercial premixes composed of demethylation-inhibitors (EPOXiconazole, CYPRoconazole, PROThioconazole, TEBUconazole), quinone-outside inhibitors (AZOXystrobin, TriFLoXystrobin, PYRAclostrobin, PICOxystrobin), and succinate demethylation inhibitors (BENZovindiflupyr, BIXaFen, FLUXapyroxad). We updated results on the performance of eight premixes evaluated in 177 cooperative trials conducted in 46 locations across 10 states during six crop seasons (2015 to 2020). All treatments were sprayed three times starting at R1 or R2. Percent control (C, %), from back-transforming meta-analytic estimates of the log of the ratio ranged from 56.2% (PICO + CYPR) to 76.8% (BIXF + TFLX + PROT). Estimates of mean yield difference (D, kg/ha) between fungicide-treated and untreated plots were greatest for BIXF + TFLX + PROT (1,080) followed by PICO + BENZ (1,010), PYRA + EPOX + FLUX (981.5), AZOX + BENZ (910), TFLX + PROT (891), PICO + TEBU (682), TFLX + CYPR (646) and PICO + CYPR (600). Significant declines in both C and D in a time period as short as four years were detected for AZOX + BENZ (35.3%; 550 kg/ha) and PICO + BENZ (15.5%; 359.8 kg/ha). Variance in D was partially reduced by the inclusion of baseline disease as covariate. In trials where baseline disease was ≥70%, yield was 250 kg/ha greater compared to low baseline disease. Disease control and yield response were generally better in the Southeast, where the frequency of profitable scenarios was 30% higher on average than in the Northwest. Results of this meta-analysis are critical to support decisions during planning fungicide programs.