scholarly journals Evaluating Posterior Cruciate Ligament Integrity in Inflammatory Arthritis Patients Prescribed Biologic Agents: A Radiological Case-Control Study

Cureus ◽  
2021 ◽  
Author(s):  
Patrick Nolan ◽  
Michael O'Sullivan ◽  
Áine Gorman ◽  
Stephen Eustace ◽  
Ausaf Mohammad ◽  
...  
Keyword(s):  
Posterior Cruciate Ligament ◽  
Inflammatory Arthritis ◽  
Case Control Study ◽  
Cruciate Ligament ◽  
Case Control ◽  
Biologic Agents ◽  
Control Study

scholarly journals QUANTIFICATION OF NEURAL ELEMENTS IN POSTERIOR CRUCIATE LIGAMENT: COMPARISON BETWEEN HEALTHY KNEES AND WITH PRIMARY OSTEOARTHROSIS

2021 ◽  
Vol 29 (5) ◽  
pp. 253-257
Author(s):  
MARCELO PARENTE OLIVEIRA ◽  
ROBERTO JOSÉ VIEIRA DE MELLO ◽  
LUCIANO TAVARES MONTENEGRO ◽  
SILVANIA TAVARES PAZ ◽  
DIEGO ARIEL DE LIMA ◽  
...  
Keyword(s):  
Posterior Cruciate Ligament ◽  
Lower Limb ◽  
Case Control Study ◽  
Cruciate Ligament ◽  
Case Control ◽  
Neural Element ◽  
Level Of Evidence ◽  
Primary Osteoarthrosis ◽  
Valgus Alignment ◽  
Control Study

ABSTRACT Objective: To quantify the neural elements in the posterior cruciate ligament (PCL) in healthy knees and with primary osteoarthrosis (OA). Methods: In two groups with OA, one of cadavers and another of individuals, the area of neural elements identified in histological sections of PCL with anti-S100 immunohistochemistry was quantified. Results: The overall mean area of the neural elements was 0.96% ± 0.67%, with the value in the cadaver group of 1.02% ± 0.67% and in the OA group of 0.80% ± 0.64%, with a significant statistically difference (p = 0.001). No correlation was observed between neural element quantification and the age of the individuals (p > 0.05). There was no difference in the quantification of neural elements between the sexes in the cadaver group (p = 0.766), but in the OA group there was a statistically significant reduction in males (p = 0.003). Also, in the osteoarthrosis group there was no difference in the quantification of neural elements in the knees with varus or valgus alignment (p = 0.847). Conclusion: There was a decrease in neural element quantification in PCL of individuals affected by OA in relation to non-arthritic individuals, with this quantification not related to age or with the axis of the lower limb. However, this quantification is not related to age or the axis of the lower limb. Level of Evidence III, Case control study.

The Association Between Tibial Slope and Revision Anterior Cruciate Ligament Reconstruction in Patients ≤21 Years Old: A Matched Case-Control Study Including 317 Revisions

2019 ◽  
Vol 47 (14) ◽  
pp. 3330-3338 ◽  
Author(s):  
Joseph D. Cooper ◽  
Wei Wang ◽  
Heather A. Prentice ◽  
Tadashi T. Funahashi ◽  
Gregory B. Maletis
Keyword(s):  
Ligament Reconstruction ◽  
Case Control Study ◽  
Cruciate Ligament ◽  
Tibial Slope ◽  
Case Control ◽  
Matched Case ◽  
Slope Difference ◽  
Anterior Cruciate ◽  
Matched Case Control Study ◽  
Control Study

Background: There is evidence that tibial slope may play a role in revision risk after anterior cruciate ligament reconstruction (ACLR); however, prior studies are inconsistent. Purpose: To determine (1) whether there is a difference in lateral tibial posterior slope (LTPS) or medial tibial posterior slope (MTPS) between patients undergoing revised ACLR and those not requiring revision and (2) whether the medial-to-lateral slope difference is different between these 2 groups. Study Design: Case-control study; Level of evidence, 3. Methods: We conducted a matched case-control study (2006-2015). Cases were patients aged ≤21 years who underwent revision surgery after primary unilateral ACLR; controls were patients aged ≤21 years without revision who were identified from the same source population. Controls were matched to cases by age, sex, body mass index, race, graft type, femoral fixation device, and post-ACLR follow-up time. Tibial slope measurements were made by a single blinded reviewer using magnetic resonance imaging. The Wilcoxon signed rank test and McNemar test were used for continuous and categorical variables, respectively. Results: No difference was observed between revised and nonrevised ACLR groups for LTPS (median: 6° vs 6°, P = .973) or MTPS (median: 4° vs 5°, P = .281). Furthermore, no difference was found for medial-to-lateral slope difference (median: −1 vs −1, P = .289). A greater proportion of patients with revised ACLR had an LTPS ≥12° (7.6% vs 3.8%) and ≥13° (4.7% vs 1.3%); however, this was not statistically significant after accounting for multiple testing. Conclusion: We failed to observe an association between revision ACLR surgery and LTPS, MTPS, or medial-to-lateral slope difference. However, there was a greater proportion of patients in the revision ACLR group with an LTPS ≥12°, suggesting that a minority of patients who have more extreme values of LTPS have a higher revision risk after primary ACLR. A future cohort study evaluating the angle that best differentiates patients at highest risk for revision is needed.

scholarly journals Oral contraceptive use and anterior cruciate ligament injury: comparison of active comparator new user cohort and case-control study designs

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Mackenzie M. Herzog ◽  
Jessica C. Young ◽  
Jennifer L. Lund ◽  
Virginia Pate ◽  
Christina D. Mack ◽  
...  
Keyword(s):  
Case Control Study ◽  
Cruciate Ligament ◽  
Cohort Analysis ◽  
Acl Injury ◽  
Case Control ◽  
Case Control Studies ◽  
Active Comparator ◽  
Protective Association ◽  
Anterior Cruciate ◽  
Control Study

Abstract Background This study further investigates a protective association between oral contraceptive (OC) use and anterior cruciate ligament (ACL) injury noted in prior case-control studies. Methods Active comparator new user cohort analysis of women aged 13–45 years in the United States from the IBM MarketScan Commercial Claims and Encounters database who newly-initiated low-dose OCs (exposed) or underwent intrauterine device (IUD) insertion (comparison group) from 2000 to 2014. Women were followed for ACL injury starting 90 days after OC initiation or IUD insertion until OC or IUD discontinuation or end of continuous enrollment. Adjusted hazard ratios (adjHR) and 95% confidence intervals (CI) were estimated controlling for age. Secondary analysis replicated previously-published case-control studies assessing “ever” versus “never” OC use over 1- and 5-year periods among women who underwent ACL reconstruction compared to age-matched controls. Results In the cohort analysis, 2,370,286 women initiated OCs and 621,798 underwent IUD insertion. There were 3571 (0.15%) ACL injuries during an average 370.6 days of continuous OC use and 1620 (0.26%) during an average 590.5 days of IUD use. No difference in risk of ACL injury was observed between OC initiators and IUD users (adjHR = 0.95; 95%CI 0.89, 1.01). The case-control analysis replicated the slight protective association observed in prior studies over a 5-year period (OR = 0.90; 95%CI 0.85, 0.94). Conclusions This cohort study suggests no association between OC use and ACL injury, while the case-control study suggested bias from uncontrolled confounding and selection factors may have influenced previous findings that suggested a protective association between OC use and ACL injury.

scholarly journals ACL and meniscal injuries increase the risk of primary total knee replacement for osteoarthritis: a matched case–control study using the Clinical Practice Research Datalink (CPRD)

2018 ◽  
Vol 53 (15) ◽  
pp. 965-968 ◽  
Author(s):  
Tanvir Khan ◽  
Abtin Alvand ◽  
Daniel Prieto-Alhambra ◽  
David J Culliford ◽  
Andrew Judge ◽  
...  
Keyword(s):  
Inflammatory Arthritis ◽  
Case Control Study ◽  
Case Control ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Meniscal Injury ◽  
Total Knee ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

ObjectivesThe aim of this study was to investigate whether ACL injury (ACLi) or meniscal injury increases the risk of end-stage osteoarthritis (OA) resulting in total knee replacement (TKR).MethodsA matched case–control study of all TKRs performed in the UK between January 1990 and July 2011 and recorded in the Clinical Practice Research Datalink (CPRD) was undertaken. The CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case of TKR, matched on age, sex and general practitioner location as a proxy for socioeconomic status. Individuals with inflammatory arthritis were excluded. The odds of having TKR for individuals with a CPRD-recorded ACLi were compared with those without ACLi using conditional logistic regression, after adjustment for body mass index, previous knee fracture and meniscal injury. The adjusted odds of TKR in individuals with a recorded meniscal injury compared with those without were calculated.ResultsAfter exclusion of individuals with inflammatory arthritis, there were 49 723 in the case group and 104 353 controls. 153 (0.31%) cases had a history of ACLi compared with 41 (0.04%) controls. The adjusted OR of TKR after ACLi was 6.96 (95% CI 4.73 to 10.31). 4217 (8.48%) individuals in the TKR group had a recorded meniscal injury compared with 669 (0.64%) controls. The adjusted OR of TKR after meniscal injury was 15.24 (95% CI 13.88 to 16.69).ConclusionThis study demonstrates that ACLi is associated with a sevenfold increased odds of TKR resulting from OA. Meniscal injury is associated with a 15-fold increase odds of TKR for OA.

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