scholarly journals QUANTIFICATION OF NEURAL ELEMENTS IN POSTERIOR CRUCIATE LIGAMENT: COMPARISON BETWEEN HEALTHY KNEES AND WITH PRIMARY OSTEOARTHROSIS

2021 ◽  
Vol 29 (5) ◽  
pp. 253-257
Author(s):  
MARCELO PARENTE OLIVEIRA ◽  
ROBERTO JOSÉ VIEIRA DE MELLO ◽  
LUCIANO TAVARES MONTENEGRO ◽  
SILVANIA TAVARES PAZ ◽  
DIEGO ARIEL DE LIMA ◽  
...  
Keyword(s):  
Posterior Cruciate Ligament ◽  
Lower Limb ◽  
Case Control Study ◽  
Cruciate Ligament ◽  
Case Control ◽  
Neural Element ◽  
Level Of Evidence ◽  
Primary Osteoarthrosis ◽  
Valgus Alignment ◽  
Control Study

ABSTRACT Objective: To quantify the neural elements in the posterior cruciate ligament (PCL) in healthy knees and with primary osteoarthrosis (OA). Methods: In two groups with OA, one of cadavers and another of individuals, the area of neural elements identified in histological sections of PCL with anti-S100 immunohistochemistry was quantified. Results: The overall mean area of the neural elements was 0.96% ± 0.67%, with the value in the cadaver group of 1.02% ± 0.67% and in the OA group of 0.80% ± 0.64%, with a significant statistically difference (p = 0.001). No correlation was observed between neural element quantification and the age of the individuals (p > 0.05). There was no difference in the quantification of neural elements between the sexes in the cadaver group (p = 0.766), but in the OA group there was a statistically significant reduction in males (p = 0.003). Also, in the osteoarthrosis group there was no difference in the quantification of neural elements in the knees with varus or valgus alignment (p = 0.847). Conclusion: There was a decrease in neural element quantification in PCL of individuals affected by OA in relation to non-arthritic individuals, with this quantification not related to age or with the axis of the lower limb. However, this quantification is not related to age or the axis of the lower limb. Level of Evidence III, Case control study.

The Association Between Tibial Slope and Revision Anterior Cruciate Ligament Reconstruction in Patients ≤21 Years Old: A Matched Case-Control Study Including 317 Revisions

2019 ◽  
Vol 47 (14) ◽  
pp. 3330-3338 ◽  
Author(s):  
Joseph D. Cooper ◽  
Wei Wang ◽  
Heather A. Prentice ◽  
Tadashi T. Funahashi ◽  
Gregory B. Maletis
Keyword(s):  
Ligament Reconstruction ◽  
Case Control Study ◽  
Cruciate Ligament ◽  
Tibial Slope ◽  
Case Control ◽  
Matched Case ◽  
Slope Difference ◽  
Anterior Cruciate ◽  
Matched Case Control Study ◽  
Control Study

Background: There is evidence that tibial slope may play a role in revision risk after anterior cruciate ligament reconstruction (ACLR); however, prior studies are inconsistent. Purpose: To determine (1) whether there is a difference in lateral tibial posterior slope (LTPS) or medial tibial posterior slope (MTPS) between patients undergoing revised ACLR and those not requiring revision and (2) whether the medial-to-lateral slope difference is different between these 2 groups. Study Design: Case-control study; Level of evidence, 3. Methods: We conducted a matched case-control study (2006-2015). Cases were patients aged ≤21 years who underwent revision surgery after primary unilateral ACLR; controls were patients aged ≤21 years without revision who were identified from the same source population. Controls were matched to cases by age, sex, body mass index, race, graft type, femoral fixation device, and post-ACLR follow-up time. Tibial slope measurements were made by a single blinded reviewer using magnetic resonance imaging. The Wilcoxon signed rank test and McNemar test were used for continuous and categorical variables, respectively. Results: No difference was observed between revised and nonrevised ACLR groups for LTPS (median: 6° vs 6°, P = .973) or MTPS (median: 4° vs 5°, P = .281). Furthermore, no difference was found for medial-to-lateral slope difference (median: −1 vs −1, P = .289). A greater proportion of patients with revised ACLR had an LTPS ≥12° (7.6% vs 3.8%) and ≥13° (4.7% vs 1.3%); however, this was not statistically significant after accounting for multiple testing. Conclusion: We failed to observe an association between revision ACLR surgery and LTPS, MTPS, or medial-to-lateral slope difference. However, there was a greater proportion of patients in the revision ACLR group with an LTPS ≥12°, suggesting that a minority of patients who have more extreme values of LTPS have a higher revision risk after primary ACLR. A future cohort study evaluating the angle that best differentiates patients at highest risk for revision is needed.

scholarly journals Oral contraceptive use and anterior cruciate ligament injury: comparison of active comparator new user cohort and case-control study designs

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Mackenzie M. Herzog ◽  
Jessica C. Young ◽  
Jennifer L. Lund ◽  
Virginia Pate ◽  
Christina D. Mack ◽  
...  
Keyword(s):  
Case Control Study ◽  
Cruciate Ligament ◽  
Cohort Analysis ◽  
Acl Injury ◽  
Case Control ◽  
Case Control Studies ◽  
Active Comparator ◽  
Protective Association ◽  
Anterior Cruciate ◽  
Control Study

Abstract Background This study further investigates a protective association between oral contraceptive (OC) use and anterior cruciate ligament (ACL) injury noted in prior case-control studies. Methods Active comparator new user cohort analysis of women aged 13–45 years in the United States from the IBM MarketScan Commercial Claims and Encounters database who newly-initiated low-dose OCs (exposed) or underwent intrauterine device (IUD) insertion (comparison group) from 2000 to 2014. Women were followed for ACL injury starting 90 days after OC initiation or IUD insertion until OC or IUD discontinuation or end of continuous enrollment. Adjusted hazard ratios (adjHR) and 95% confidence intervals (CI) were estimated controlling for age. Secondary analysis replicated previously-published case-control studies assessing “ever” versus “never” OC use over 1- and 5-year periods among women who underwent ACL reconstruction compared to age-matched controls. Results In the cohort analysis, 2,370,286 women initiated OCs and 621,798 underwent IUD insertion. There were 3571 (0.15%) ACL injuries during an average 370.6 days of continuous OC use and 1620 (0.26%) during an average 590.5 days of IUD use. No difference in risk of ACL injury was observed between OC initiators and IUD users (adjHR = 0.95; 95%CI 0.89, 1.01). The case-control analysis replicated the slight protective association observed in prior studies over a 5-year period (OR = 0.90; 95%CI 0.85, 0.94). Conclusions This cohort study suggests no association between OC use and ACL injury, while the case-control study suggested bias from uncontrolled confounding and selection factors may have influenced previous findings that suggested a protective association between OC use and ACL injury.

scholarly journals Risk Factors for Acute Cellulitis of the Lower Limb: A Prospective Case-Control Study

2005 ◽  
Vol 41 (10) ◽  
pp. 1416-1422 ◽  
Author(s):  
S. Bjornsdottir ◽  
M. Gottfredsson ◽  
A. S. Thorisdottir ◽  
G. B. Gunnarsson ◽  
H. Rikardsdottir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lower Limb ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Risk factors of lower limb cellulitis in a level-two healthcare facility in Cameroon: a case-control study

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Tsi Njim ◽  
Leopold Ndemnge Aminde ◽  
Valirie Ndip Agbor ◽  
Louise Daniele Toukam ◽  
Sara Saheb Kashaf ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lower Limb ◽  
Case Control Study ◽  
Healthcare Facility ◽  
Case Control ◽  
Control Study
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