scholarly journals A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia

Cureus ◽  
2021 ◽  
Author(s):  
S. Charles Bronson ◽  
E. Suresh ◽  
S. Stephen Abraham Suresh Kumar ◽  
C. Mythili ◽  
A. Shanmugam
Keyword(s):  
Intellectual Disability ◽  
Hair Cell ◽  
Vertebral Artery ◽  
Outer Hair Cell ◽  
Cerebellar Atrophy ◽  
Cell Dysfunction ◽  
Vertebral Artery Hypoplasia

Estimation of the degree of inner and outer hair cell dysfunction from distortion product otoacoustic emission input/output functions

2009 ◽  
Vol 7 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Enrique A. Lopez-Poveda ◽  
Peter T. Johannesen ◽  
Miguel A. Merchán
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Input Output ◽  
Cell Dysfunction ◽  
Distortion Product

scholarly journals Across-frequency behavioral estimates of the contribution of inner and outer hair cell dysfunction to individualized audiometric loss

2014 ◽  
Vol 8 ◽  
Author(s):  
Peter T. Johannesen ◽  
Patricia Pérez-González ◽  
Enrique A. Lopez-Poveda
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Cell Dysfunction

scholarly journals Behavioral Estimates of the Contribution of Inner and Outer Hair Cell Dysfunction to Individualized Audiometric Loss

2012 ◽  
Vol 13 (4) ◽  
pp. 485-504 ◽  
Author(s):  
Enrique A. Lopez-Poveda ◽  
Peter T. Johannesen
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Cell Dysfunction

Modeling the Mechanics of Tethers Pulled From the Cochlear Outer Hair Cell Membrane

2008 ◽  
Vol 130 (3) ◽  
Author(s):  
Kristopher R. Schumacher ◽  
Aleksander S. Popel ◽  
Bahman Anvari ◽  
William E. Brownell ◽  
Alexander A. Spector
Keyword(s):  
Cell Membrane ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall ◽  
Outer Hair Cells ◽  
The Body ◽  
Computational Method ◽  
Membrane Properties ◽  
Bending Modulus ◽  
Sound Amplification

Cell membrane tethers are formed naturally (e.g., in leukocyte rolling) and experimentally to probe membrane properties. In cochlear outer hair cells, the plasma membrane is part of the trilayer lateral wall, where the membrane is attached to the cytoskeleton by a system of radial pillars. The mechanics of these cells is important to the sound amplification and frequency selectivity of the ear. We present a modeling study to simulate the membrane deflection, bending, and interaction with the cytoskeleton in the outer hair cell tether pulling experiment. In our analysis, three regions of the membrane are considered: the body of a cylindrical tether, the area where the membrane is attached and interacts with the cytoskeleton, and the transition region between the two. By using a computational method, we found the shape of the membrane in all three regions over a range of tether lengths and forces observed in experiments. We also analyze the effects of biophysical properties of the membrane, including the bending modulus and the forces of the membrane adhesion to the cytoskeleton. The model’s results provide a better understanding of the mechanics of tethers pulled from cell membranes.

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