scholarly journals Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia

Cureus ◽  
2021 ◽  
Author(s):  
Gurneet Shaheed ◽  
Anthony P Manjooran ◽  
Akshay J Reddy ◽  
Neel Nawathey ◽  
Samuel Habib ◽  
...  
Keyword(s):  
Low Dose ◽  
Opioid Induced Hyperalgesia ◽  
Low Dose Naltrexone

scholarly journals The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia

2021 ◽  
Vol 12 ◽  
Author(s):  
Daniel Jackson ◽  
Sunita Singh ◽  
Yanli Zhang-James ◽  
Stephen Faraone ◽  
Brian Johnson
Keyword(s):  
Low Dose ◽  
Clinical Care ◽  
Cold Pressor Test ◽  
Case Series ◽  
Pain Tolerance ◽  
Control Group ◽  
Addiction Medicine ◽  
Endogenous Opioid ◽  
Opioid Induced Hyperalgesia ◽  
Low Dose Naltrexone

Objectives:While opioids temporarily alleviate pain, the overshoot of balancing pain drivers may increase pain, leading to opioid induced hyperalgesia (OIH). Our goal was to find out what chronic opioid treatment does to pain tolerance as measured by the cold pressor test (CPT), an objective measure of pain tolerance, and to find an alternative effective treatment for chronic pain and FM.Materials and Methods:The setting was an academic addiction medicine service that has an embedded pain service. Patients had routine clinical care starting with an evaluation that included assessment of medical and psychiatric conditions. Participants were 55 patients with OIH and 21 patients with fibromyalgia; all had at least two CPTs. Treatment included a single dose of buprenorphine for detoxification. In this open-label case series, patients were treated with low dose naltrexone (LDN), a pure opioid receptor antagonist that, we hypothesize, treats OIH and FM by restoring endogenous opioid tone.Results:Comparing initial and last CPT times, those with OIH more than quadrupled their pain tolerance, and those with FM doubled theirs. This improved pain tolerance for OIH and FM was statistically significant (p< 0.0001 andp= 0.003, respectively) and had a large effect size (r= 0.82 andr= 0.63, respectively).Discussion:Results suggest that patients on chronic opioid therapy should have pain tolerance measured by CPT with detoxification and LDN provided to correct opioid induced hyperalgesia if found. FM may also be treated with LDN. The main limitation of the findings was lack of a randomized control group treated with placebo.

Low Dose Naltrexone in the Treatment of Fibromyalgia

2018 ◽  
Vol 14 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Samy K Metyas ◽  
Christina L. Chen ◽  
Karen Yeter ◽  
John Solyman ◽  
Daniel Arkfeld
Keyword(s):  
Low Dose ◽  
Low Dose Naltrexone

scholarly journals Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

2021 ◽  
Vol 14 (4) ◽  
pp. 101028
Author(s):  
Ning Liu ◽  
Limei Yan ◽  
Fengping Shan ◽  
Xiaonai Wang ◽  
Na Qu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Progression ◽  
Low Dose ◽  
Mtor Pathway ◽  
Low Dose Naltrexone

Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy

2021 ◽  
Vol 96 ◽  
pp. 107714
Author(s):  
Na Qu ◽  
Yiming Meng ◽  
Mike K. Handley ◽  
Chunyan Wang ◽  
Fengping Shan
Keyword(s):  
Clinical Studies ◽  
Low Dose ◽  
Preclinical And Clinical Studies ◽  
Low Dose Naltrexone
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