Evaluation of Skeletal Muscle Dysfunction Associated With Acute Inflammation by Electrical Impedance Myography: A Case Report on Skeletal Muscle Dysfunction After Cardiac Surgery and Literature Review

A number of chronic illnesses such as renal failure (CRF), obstructive pulmonary disease, and congestive heart failure result in a significant decrease in exercise tolerance. There is an increasing awareness that prescribed exercise, designed to restore some level of physical performance and quality of life, can be beneficial in these conditions. In CRF patients, muscle function can be affected by a number of direct and indirect mechanisms caused by renal disease as well as various treatment modalities. The aims of this review are twofold: first, to briefly discuss the mechanisms by which CRF negatively impacts skeletal muscle and, therefore, exercise capacity, and, second, to discuss the available data on the effects of programmed exercise on muscle function, exercise capacity, and various other parameters in CRF.

Download Full-text

Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes

Archivos de Bronconeumología ◽

10.1016/j.arbres.2019.12.034 ◽

2020 ◽

Cited By ~ 1

Author(s):

Clayton L. Cruthirds ◽

Barbara S. van der Meij ◽

Agata Wierzchowska-McNew ◽

Nicolaas E.P. Deutz ◽

Mariëlle P.K.J. Engelen

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Skeletal Muscle ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Muscle Dysfunction ◽

Obstructive Pulmonary Disease ◽

Skeletal Muscle Dysfunction

Download Full-text

Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00540.2015 ◽

2016 ◽

Vol 311 (2) ◽

pp. E293-E301 ◽

Cited By ~ 23

Author(s):

Laura A. A. Gilliam ◽

Daniel S. Lark ◽

Lauren R. Reese ◽

Maria J. Torres ◽

Terence E. Ryan ◽

...

Keyword(s):

Skeletal Muscle ◽

Cancer Chemotherapy ◽

Protein Oxidation ◽

Muscle Function ◽

Contractile Function ◽

Muscle Dysfunction ◽

Skeletal Muscle Dysfunction ◽

Whole Muscle ◽

Loss Of Strength ◽

Mitochondrial Respiratory

The loss of strength in combination with constant fatigue is a burden on cancer patients undergoing chemotherapy. Doxorubicin, a standard chemotherapy drug used in the clinic, causes skeletal muscle dysfunction and increases mitochondrial H2O2. We hypothesized that the combined effect of cancer and chemotherapy in an immunocompetent breast cancer mouse model (E0771) would compromise skeletal muscle mitochondrial respiratory function, leading to an increase in H2O2-emitting potential and impaired muscle function. Here, we demonstrate that cancer chemotherapy decreases mitochondrial respiratory capacity supported with complex I (pyruvate/glutamate/malate) and complex II (succinate) substrates. Mitochondrial H2O2-emitting potential was altered in skeletal muscle, and global protein oxidation was elevated with cancer chemotherapy. Muscle contractile function was impaired following exposure to cancer chemotherapy. Genetically engineering the overexpression of catalase in mitochondria of muscle attenuated mitochondrial H2O2 emission and protein oxidation, preserving mitochondrial and whole muscle function despite cancer chemotherapy. These findings suggest mitochondrial oxidants as a mediator of cancer chemotherapy-induced skeletal muscle dysfunction.

Download Full-text