scholarly journals Markers of Oxidative Stress, Inflammation and Endothelial Dysfunction in ESRD Patients with Hepatitis-C Virus Positive on Maintenance Haemodialysis

2018 ◽  
Author(s):  
Krishna Kishore Chennu ◽  
Niimmanapalli Harini Devi ◽  
PVLN Srinivasa Rao ◽  
AY Lakshmi ◽  
Vishnubotla Siva Kumar
Keyword(s):  
Oxidative Stress ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Endothelial Dysfunction ◽  
Maintenance Haemodialysis ◽  
Markers Of Oxidative Stress ◽  
Esrd Patients

scholarly journals HCV-Induced Oxidative Stress: Battlefield-Winning Strategy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Khadija Rebbani ◽  
Kyoko Tsukiyama-Kohara
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Infection ◽  
Liver Diseases ◽  
Winning Strategy ◽  
Critical Role ◽  
Markers Of Oxidative Stress ◽  
Induce Hepatocarcinogenesis

About 150 million people worldwide are chronically infected with hepatitis C virus (HCV). The persistence of the infection is controlled by several mechanisms including the induction of oxidative stress. HCV relies on this strategy to redirect lipid metabolism machinery and escape immune response. The 3β-hydroxysterol Δ24-reductase (DHCR24) is one of the newly discovered host markers of oxidative stress. This protein, as HCV-induced oxidative stress responsive protein, may play a critical role in the pathogenesis of HCV chronic infection and associated liver diseases, when aberrantly expressed. The sustained expression of DHCR24 in response to HCV-induced oxidative stress results in suppression of nuclear p53 activity by blocking its acetylation and increasing its interaction with MDM2 in the cytoplasm leading to its degradation, which may induce hepatocarcinogenesis.

scholarly journals Branched‐chain amino acids reduce hepatic iron accumulation and oxidative stress in hepatitis C virus polyprotein‐expressing mice

2014 ◽  
Vol 35 (4) ◽  
pp. 1303-1314 ◽  
Author(s):  
Masaaki Korenaga ◽  
Sohji Nishina ◽  
Keiko Korenaga ◽  
Yasuyuki Tomiyama ◽  
Naoko Yoshioka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Branched Chain Amino Acids ◽  
Iron Accumulation ◽  
Hepatic Iron ◽  
Branched Chain ◽  
Virus Polyprotein ◽  
And Oxidative Stress

Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

2006 ◽  
Vol 290 (5) ◽  
pp. G847-G851 ◽  
Author(s):  
Jinah Choi ◽  
J.-H. James Ou
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Iron Overload ◽  
Antioxidant Defense ◽  
Hcv Infection ◽  
Nitrogen Species ◽  
Systemic Oxidative Stress

Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. The increased generation of reactive oxygen and nitrogen species, together with the decreased antioxidant defense, promotes the development and progression of hepatic and extrahepatic complications of HCV infection. This review discusses the possible mechanisms of HCV-induced oxidative stress and its role in HCV pathogenesis.

[433] FK506 AMELIORATES METABOLIC DISTURBANCE AND OXIDATIVE STRESS IN HEPATITIS C VIRUS INFECTION

2007 ◽  
Vol 46 ◽  
pp. S165-S166
Author(s):  
K. Moriya ◽  
H. Miyoshi ◽  
S. Shinzawa ◽  
T. Tsutsumi ◽  
H. Fujie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Metabolic Disturbance ◽  
Hepatitis C Virus Infection ◽  
And Oxidative Stress
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