existence of tourism higher education under the ministry of tourism and creative economy (PTNP) toward Indonesia’s golden generation 2045

The purpose of this study was to analyze and determine the strategy of Tourism Higher Education (PTNP) operated by the Ministry of Tourism and Creative Economy Republic of Indonesia towards vision Indonesia’s Golden Generation 2045. This research is a policy research to solve social problems that aims to identify the implementation of adaptation, innovation, and collaboration strategy. The results of this study indicated that Tourism Higher Education (PTNP) in the face of two main trends, namely globalization and pandemic COVID-19. The winning strategy of Tourism Higher Education (PTNP) were, 1) Adaption strategy, by provided facilities and support the lecturer and faculty members to use hightech and also strictly discipline with CHSE standard to protect the spread of COVID-19 pandemic. 2) Innovation strategy, by using hightech in education and curriculum designed to facilitate long distance learning as well as the development of big data for personnel, finance, logistics and students so that it will facilitate access to information and strategic decision making. 3) Collaboration strategy, by sharing utilization and industry expert on training and education as well as job recruitment and internship program.

Pharmacological, Technological, and Digital Innovative Aspects in Rhinology

Innovation refers to the introduction of a product, a process, a service or a solution resulting in something new or significantly improved compared to the already available alternatives. In the clinical context, it is strictly related to the identification of a new added value in terms of quality, therapeutic efficacy and safety. Over the years several innovative approaches have been introduced in the clinical practice, revolutionizing the treatment and the management of important rhinologic conditions. Innovative tools, including new drugs, biomaterials, and mobile applications seem to be able to improve the clinical outcomes and the quality of life of many patients affected by (often relapsing) rhinologic diseases. Among the main modern pharmacological innovations, mention must be made of the biological drugs like monoclonal antibodies (mAbs). Recently, new mAbs have been introduced and investigated as useful arms in the treatment of some inflammatory/infectious or oncological diseases affecting the nasal cavities and paranasal sinuses. The already approved or still investigated mAbs work inhibiting different type 2 inflammation pathways, including those mediated by IgE (omalizumab), IL-4/IL-13 (dupilumab), and IL-5 (mepolizumab). Moreover, considering the higher expression of PD-L1 in nasopharyngeal carcinoma, the use of PD-1 inhibitors, such as nivolumab, or a dual CTLA-4/PD-1 blockade (ipilimumab plus nivolumab) appear to be an effective strategy for the treatment of this cancer form. The implants with bio-absorbable biomaterials represent new interesting available technological innovations. Moreover, advanced technologies such as the artificial intelligence, the machine learning as well as the augmented or virtual reality have also proved useful in rhinologic field with main impacts on precision medicine and surgery. Finally, the development and use of mobile-Health tools represent a winning strategy in monitoring of the therapy success, safety and tolerability as well as the progress of chronic disease including chronic rhinosinusitis with nasal polyps. Supporting the research of innovative tools and strategies (including pharmacological, technologic, or digital ones) is essential to improve the management of chronic diseases that significantly affect the patients' quality of life.

Introducing New 22? PDC Bit for Drilling Complex Shallow Sections in a Giant Field in the Middle East

Drilling a 22″ section across interbedded, high-impact, and abrasive formations has historically been challenging in giant fields in the Middle East. The section typically ranges from 3,000 ft to 4,000 ft long and requires three to four runs to reach the casing point with conventional TCI bits. This paper covers the introduction of a new 22″ PDC bit design run on rotary assembly, which has spectacularly improved the drilling performance over the conventional tricone bits. The introduction of this new 22″ PDC bit design followed a comprehensive engineering approach. Starting with the simulation of rock properties such as compressive strength, abrasiveness, and impact, a fit-for-purpose bit design was manufactured to address the needed cutting structure, number of blades, and depth of cut for the section. The downhole drilling dynamics were also thoroughly analyzed, and the bottom hole assembly configuration was revisited to match up with the new bit structure. Within the dedicated continuous improvement workflow set by the service company, the bit pattern was further optimized after the initial field trials. After an in-depth analysis of the various formation properties and their impact on bit life, the 22″ section was divided into two target runs. The upper part has high-impact and interbedded layers, and the lower part has high abrasiveness and formation compressive strength. In the upper part, the TCI bits had previously shown relatively good performance with acceptable ROP, while the PDC bits experienced damage to their cutting structure. As the impacts were lower in the bottom part, the PDC bit design was selected for the second run to the casing point, which resulted in significantly higher ROP and a longer lifetime than the TCI runs. The 2-bit strategy, spudding the section with the TCI bit and completing it with the PDC bit on rotary assembly, translated into a significant improvement of ROP by 32%. In addition to saving rig time, the overall number of bit runs was reduced by 29%, resulting in cost savings by using fewer bits. Drilling the section in two runs has now become the norm, and this winning strategy was adopted as the new standard for drilling the 22″ hole section. The introduction of the 22″ PDC bit on rotary drive returned excellent results and record-breaking ROP performance. While the 22″ PDC cost might seem prohibitive, the substantial rig time savings proved this solution to be very economical. Further development of this initiative to other basins in the Middle East or elsewhere will mutually benefit both the operator and service company.

A Novel L-Shaped Fluorescent Probe for AIE Sensing of Zinc (II) Ion by a DR/NIR Response

In the field of optical sensors, small molecules responsive to metal cations are of current interest. Probes displaying aggregation-induced emission (AIE) can solve the problems due to the aggregation-caused quenching (ACQ) molecules, scarcely emissive as aggregates in aqueous media and in tissues. The addition of a metal cation to an AIE ligand dissolved in solution can cause a “turn-on” of the fluorescence emission. Half-cruciform-shaped molecules can be a winning strategy to build specific AIE probes. Herein, we report the synthesis and characterization of a novel L-shaped fluorophore containing a benzofuran core condensed with 3-hydroxy-2-naphthaldehyde crossed with a nitrobenzene moiety. The novel AIE probe produces a fast colorimetric and fluorescence response toward zinc (II) in both in neutral and basic conditions. Acting as a tridentate ligand, it produces a complex with enhanced and red-shifted emission in the DR/NIR spectral range. The AIE nature of both compounds was examined on the basis of X-ray crystallography and DFT analysis.

Socratic Irony and Argumentation

Socratic irony can be understood independently of the immortal heroics of Plato’s Socrates. We need a systematic account and criticism of it both as a debate-winning strategy of argumentation and teaching method. The Speaker introduces an issue pretending to be at a lower intellectual level than her co-debaters, or Participants. An Audience looks over and evaluates the results. How is it possible that the Speaker like Socrates is, consistently, in the winning position? The situation is ironic because the Participants fight from a losing position but realize it too late. Socratic irony compares with divine irony: divine irony is a subtype of Socratic irony since you lose when you challenge gods. Socratic irony is also, prima facie, a subtype of dramatic irony when the Audience knows more than the Participants on the stage. We must distinguish between the ideal and realistic elements of Socratic Irony. The very idea of Socratic irony looks idealized, or it is an ideal case, which explains the Speaker’s consistently winning position. In real life, the debate must be rigged, or the Dutch Book argument applies to the Participants, if the Speaker is so successful.

Brain Synchrony in Competition and Collaboration During Multiuser Neurofeedback-Based Gaming

EEG hyperscanning during multiuser gaming offers opportunities to study brain characteristics of social interaction under various paradigms. In this study, we aimed to characterize neural signatures and phase-based functional connectivity patterns of gaming strategies during collaborative and competitive alpha neurofeedback games. Twenty pairs of participants with no close relationship took part in three sessions of collaborative or competitive multiuser neurofeedback (NF), with identical graphical user interface, using Relative Alpha (RA) power as a control signal. Collaborating dyads had to keep their RA within 5% of each other for the team to be awarded a point, while members of competitive dyads scored points if their RA was 10% above their opponent's. Interbrain synchrony existed only during gaming but not during baseline in either collaborative or competitive gaming. Spectral analysis and interbrain connectivity showed that in collaborative gaming, players with higher resting state alpha content were more active in regulating their RA to match those of their partner. Moreover, interconnectivity was the strongest between homologous brain structures of the dyad in theta and alpha bands, indicating a similar degree of planning and social exchange. Competitive gaming emphasized the difference between participants who were able to relax and, in this way, maintain RA, and those who had an unsuccessful approach. Analysis of interbrain connections shows engagement of frontal areas in losers, but not in winners, indicating the formers' attempt to mentalise and apply strategies that might be suitable for conventional gaming, but inappropriate for the alpha neurofeedback-based game. We show that in gaming based on multiplayer non-verbalized NF, the winning strategy is dependent on the rules of the game and on the behavior of the opponent. Mental strategies that characterize successful gaming in the physical world might not be adequate for NF-based gaming.

A New Recipe for Friction-Reducer Suppliers: Polymer Plus Frac Water, Minus the Cost

The argument for making friction reducer on site is simple: only one truck is required to deliver dry polymer vs. three loads required for the same amount of liquid additive. For Downhole Chemical Solutions (DCS), reducing the number of trips and the amount of chemicals needed to create a stable liquid by mixing it as needed on site reduces the average cost of a gallon of friction reducer by around 30%, said Mark Van Domelen, vice president of technology for DCS. “The business is very cutthroat and competitive on the pricing of polyacrylamide. We can reduce the cost further on friction reducer,” using dry polymer, he said. Polyacrylamide is generally described as the key component in friction reducers. Suppliers also add some ingredients to create a stable liquid and others that are supposed to improve performance. When DCS delivers dry polymer to a well pad to mix it on-site, the only other ingredient is water provided by the customer. It has been a winning strategy change for the private company; it has grown rapidly, even during last year’s slump. DCS increased the number of mixing units from one to 16, and dry polymer sales have grown from 10% to 90%, Van Domelen said. One of the company’s customers is John Blevins, the chief operating officer for Houston-based Hibernia Resources III and an early adopter who was a lead author of a paper on making friction reducer on site while fracturing (SPE 204176). Blevin, who uses the words “friction reducer” and “polymer” interchangeably, is the rare C-level executive who likes to manage operations from a frac van at a company that normally completes one pad at a time. The polymer is polyacrylamide. When Blevin works with DCS on a well, he purchases it directly from one of the few chemical companies that will produce the polymer based on his specifications. The price on the DCS invoice will be a price per pound that covers the cost of the polymer and the service. At Hibernia, a small private-equity and employee-owned company, there is a powerful incentive to pay close attention to the details. “When we spend a nickel, that nickel is divided among us at some point in time. If we are efficiently frugal, we are going to be better off in the long run,” Blevins said. The paper, which was presented at the Unconventional Resources Technology Conference (URTeC), included a chart showing stage-by-stage costs, with the average cost for dry stages ranging from 27% to 31% lower than similar stages that were fractured using liquids. The simplicity of the mix is a plus for Blevins whose company is especially focused on how chemicals are likely to react downhole. “We did a 6-month study before we pumped anything in the ground to make sure we had the right combination” of fracturing additives, he said. “We do study nearly every well and every landing zone to ensure the chemicals used are compatible.”

The AI gambit: leveraging artificial intelligence to combat climate change—opportunities, challenges, and recommendations

In this article, we analyse the role that artificial intelligence (AI) could play, and is playing, to combat global climate change. We identify two crucial opportunities that AI offers in this domain: it can help improve and expand current understanding of climate change, and it can contribute to combatting the climate crisis effectively. However, the development of AI also raises two sets of problems when considering climate change: the possible exacerbation of social and ethical challenges already associated with AI, and the contribution to climate change of the greenhouse gases emitted by training data and computation-intensive AI systems. We assess the carbon footprint of AI research, and the factors that influence AI’s greenhouse gas (GHG) emissions in this domain. We find that the carbon footprint of AI research may be significant and highlight the need for more evidence concerning the trade-off between the GHG emissions generated by AI research and the energy and resource efficiency gains that AI can offer. In light of our analysis, we argue that leveraging the opportunities offered by AI for global climate change whilst limiting its risks is a gambit which requires responsive, evidence-based, and effective governance to become a winning strategy. We conclude by identifying the European Union as being especially well-placed to play a leading role in this policy response and provide 13 recommendations that are designed to identify and harness the opportunities of AI for combatting climate change, while reducing its impact on the environment.