scholarly journals Histogenesis of Thyroid Gland in Dead Human Foetuses of Different Gestational Age

2018 ◽  
Author(s):  
Anandi Neel Bande ◽  
Megha Arun Doshi ◽  
Ramesh Balkrishna Vaidya ◽  
Manisha Randhir Dhobale ◽  
Nitin Radhakishan Mudiraj
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Human Foetuses

scholarly journals The relationship between the thyroid gland and body at different gestational age of developing human foetuses

2018 ◽  
Vol 9 (6) ◽  
pp. 40-44
Author(s):  
Rajeev Mukhia ◽  
Bhawani Prasad Powar
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Left Lobe ◽  
Medical Sciences ◽  
Mean Values ◽  
Gland Weight ◽  
Morphometric Features ◽  
Long Time ◽  
The Relationship ◽  
Human Foetuses

Background: Thyroid gland is one of the organs of interest for researchers since a long time. Though, detailed study about adult thyroid gland is there in the literature but thyroid gland at different stages in the foetal period is far less available.Aims and Objective: To find out the morphological and morphometric features on the development of foetal thyroid gland in relation with different gestational weeks.Materials and Methods: The study was carried in the Department of Anatomy, Manipal College of Medical Sciences, Pokhara, Nepal, on 40 human foetuses of known gestational age. The midline dissection of the neck was done to expose the thyroid gland. The shape and measurements like length, breadth and thickness of both lobe of the gland were noted.Results: The mean values of all parameters by gestational age were calculated. In the present study, the weight of foetuses showed gradual increase from 10th week to 38th weeks of gestation. In the normally developing foetuses the thyroid gland dimension and its weight also increases with increase gestational age.Conclusion: There was no more difference between the dimension of right and left lobe of thyroid gland. The study provides morphological and morphometric knowledge on the development of foetal thyroid gland from 10th week to 38th weeks of gestation. The knowledge of thyroid gland weight and dimension and body weight in relation to the gestational age might be helpful to judge the thyroid structure in preterm babies.Asian Journal of Medical Sciences Vol.9(6) 2018 40-44

scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

scholarly journals Histological Studies on Foetal Thyroid Gland of Developing Human Foetuses

2021 ◽  
Vol 17 (1) ◽  
pp. 75-80
Author(s):  
Rajeev Mukhia ◽  
Dil Islam Mansur ◽  
Mahendra Raj Pandey
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Structural Changes ◽  
Histological Study ◽  
Maturation Stage ◽  
Endocrine Gland ◽  
Long Time ◽  
Gestational Week ◽  
Preterm Babies ◽  
Colloid Formation

Introduction: Thyroid gland is the first endocrine gland to develop. It is one of the organs of interest for researchers since a long time. Though, detailed study about adult thyroid is there in the literature but histological study of thyroid gland at different stages in the foetal period is far and few. The present study aims to assess the histogenesis of thyroid gland and also to correlate the functional activity with structural changes in thyroid gland. Methods: The study was carried out on 30 foetal thyroid gland of known gestational age ranging from 10 to 38 weeks foetuses. The midline dissection of neck was done to expose the thyroid gland. After tissue processing, paraffin blocks were prepared. All sections were stained with Haematoxylin-Eosin stain. Results: In the foetuses, below 12th gestational week no colloid was detected in thyroid gland.  First appearance of colloid was observed at 14th gestational week. Parafollicular cells were found after 17th gestational week. Capsule thickness and gland vascularity increased with advancement of gestational age. The size of the peripheral follicles is larger than the central follicles. Conclusions: The study concluded the developmental stage of foetal thyroid as Precolloidal stage, Colloid formation stage, Follicular stage and Maturation stage in different gestational weeks. The knowledge on the growth and differentiation of foetal thyroid will be helpful to the clinicians to judge the thyroid structure in preterm babies.

Divergent deiodination of thyroid hormones in the separated parts of the fetal and maternal placenta in pigs

1997 ◽  
Vol 155 (2) ◽  
pp. 295-303 ◽  
Author(s):  
E Krysin ◽  
E Brzezinska-Slebodzinska ◽  
AB Slebodzinski
Keyword(s):  
Thyroid Gland ◽  
Thyroid Hormones ◽  
Gestational Age ◽  
Primary Factor ◽  
Transplacental Passage ◽  
Thyroid Status ◽  
Early Gestation ◽  
Enzymatic Mechanism ◽  
Pig Placenta ◽  
Fetal Pig

Previous work from this laboratory has shown that the thyroid gland of the fetal pig begins to function at about day 46-47 (0.40-0.415 fraction of gestational age). Sera from fetuses contain lower thyroxine (T4), 3,3',5-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) concentrations than maternal sera, except for about 2 weeks before term. The fetal T4 metabolism is dominated by the 5'-monodeiodinating activity (5'-MD). In the present study we measured the iodothyronines content, and the outer (5'-MD) and inner (5-MD) monodeiodinases activity, in homogenates of the placenta. The pig placenta, which is of the epitheliochorial type, was separated into the fetal and the maternal part. The concentrations of T4, T3 and rT3 were lower, and the deiodinating activity of 5'-MD and 5-MD higher, in the fetal than in the maternal placenta. The fetal placenta not only deiodinated more actively T4 to T3 and T4 to rT3, but degraded T3 to 3,3'-diiodothyronine (3,3'-T2) more actively than rT3 to 3,3'-T2. Such divergent deiodinating activity of T4 to T3, T3 to 3,3'-T2 and rT3 to 3,3'-T2 might favor establishing a relatively high and constant rT3 concentrations in fetal and maternal placentas, and a lower T3 in the fetal placenta. The inner ring deiodinating activity (excluding a day before parturition) was always more active in the fetal placenta, while the outer ring deiodinations varied in this respect, depending on the gestation stage. These results support the hypothesis that in the fetal pig, enzymatic deiodination of thyroid hormones forms a barrier which reduces transplacental passage of the hormones and that the fetal part of the placenta is the primary factor in the mechanism regulating the hormonal transfer. In spite of the presence of the barrier, there is an adequate maternal supply of thyroid hormones to the fetus in early gestation, which suggests that the enzymatic mechanism is influenced in some way by the thyroid status of the fetus.

MELANOCYTE-STIMULATING AND CORTICOTROPHIC ACTIVITIES IN HUMAN FOETAL PITUITARY GLANDS

1968 ◽  
Vol 58 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Abba J. Kastin ◽  
Gerhard Gennser ◽  
Akira Arimura ◽  
M. Clinton Miller ◽  
Andrew V. Schally
Keyword(s):  
Pituitary Gland ◽  
Gestational Age ◽  
Melanocyte Stimulating Hormone ◽  
Developmental Factors ◽  
Pituitary Glands ◽  
Human Foetuses ◽  
Stimulating Hormone

ABSTRACT Melanocyte-stimulating hormone (MSH) and corticotrophin (ACTH) activities were determined in the pituitary glands of 24 human foetuses ranging in gestational age from 11 to 23 weeks. Both hormonal activities were present in every pituitary gland examined. The foetal developmental factors were significantly correlated as were the MSH and ACTH activities. Although the mU per mg of ACTH correlated negatively with development, no correlation between MSH and development was found.

scholarly journals Study of ‘C ‘Cells of Thyroid Gland, its Presence & Position in Fetuses of Different Gestational Age

2017 ◽  
Vol 16 (01) ◽  
pp. 70-74
Author(s):  
Dr. Nityanand Srivastava ◽  
Dr. Jayant Kumar Verma ◽  
Nand Kishor Gupta ◽  
Adil Asghar ◽  
Dr. Monika Srivastava
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
C Cells
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