scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid  patients: a cross-sectional study in China

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Min Wang ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Cross Sectional ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion : The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Normal Thyroid Function ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

THE CONTENT OF THYROID HORMONES AND OTHER IODINATED COMPOUNDS IN THYROID TISSUE IN AUTOIMMUNE THYROIDITIS

1972 ◽  
Vol 69 (2) ◽  
pp. 309-320 ◽  
Author(s):  
B.-A. Lamberg ◽  
J. Mäenpää ◽  
V. Kivikangas ◽  
R. Karlsson ◽  
P. Saarinen
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Distribution Profile ◽  
Surgical Biopsy ◽  
Total Iodine ◽  
Hypothyroid Patients ◽  
Cellulose Column

ABSTRACT The total iodine content and the content of iodocompounds in the thyroid gland were studied in 9 patients with autoimmune thyroiditis. The thyroids were labelled in vivo with radioactive iodine before surgical biopsy. Five grams of tissue were homogenized and the iodocompounds were separated both by paper chromatography and on a cellulose column. The distribution profile of both the radioactive and the stable compounds was determined. The thyroid tissue contained on an average 11.0 ± 8.0 (sd) per cent of radioactive and 15.0 ± 9.4 per cent of stable iodothyronines. The MIT/DIT ratio was 1.16 ± 0.26 for the radioactive and 0.92 ± 0.30 for the stable compounds. Clinically evident hypothyroidism occurred only in patients with a very low iodine content and was not correlated with the proportion of iodothyronines found in the thyroid tissue. For instance, in two hypothyroid patients the iodothyronines corresponded to about 20 per cent of the iodocompounds of the tissue. These findings suggest that iodine depletion of the thyroid gland plays an important role in the development of clinical hypothyroidism in autoimmune thyroiditis and that up to a very late stage of the disease the thyroid is evidently capable of producing iodothyronines in fairly normal proportions.

scholarly journals Studies of the correlation between dual-source CT measured thyroid iodine concentrations, contents and thyroid function

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Dongmei Pan ◽  
Rui Zhai ◽  
Min Wang
Keyword(s):  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Source Ct ◽  
Total Iodine ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Dual Source ◽  
The Mean

Abstract Background The aim of this study is to investigate the correlation between dual-source CT measured iodine concentration, total iodine content and blood measured thyroid parameters.Methods Dual-source CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of thyroid. Relevant test of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of thyroid mean iodine concentration and total iodine content with blood measured thyroid function was analyzed.Result The total iodine content in thyroid was positively correlated with FT3, but negatively correlated with TSH. The mean iodine concentration of thyroid was positively correlated with both FT3 and TT3.Conclusion The thyroid iodine content measured by dual-source CT can be used to determine the human iodine nutritional status and evaluate thyroid functions, which will provide help for the diagnosis and treatment of thyroid diseases.

scholarly journals The relationship between the thyroid gland and body at different gestational age of developing human foetuses

2018 ◽  
Vol 9 (6) ◽  
pp. 40-44
Author(s):  
Rajeev Mukhia ◽  
Bhawani Prasad Powar
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Left Lobe ◽  
Medical Sciences ◽  
Mean Values ◽  
Gland Weight ◽  
Morphometric Features ◽  
Long Time ◽  
The Relationship ◽  
Human Foetuses

Background: Thyroid gland is one of the organs of interest for researchers since a long time. Though, detailed study about adult thyroid gland is there in the literature but thyroid gland at different stages in the foetal period is far less available.Aims and Objective: To find out the morphological and morphometric features on the development of foetal thyroid gland in relation with different gestational weeks.Materials and Methods: The study was carried in the Department of Anatomy, Manipal College of Medical Sciences, Pokhara, Nepal, on 40 human foetuses of known gestational age. The midline dissection of the neck was done to expose the thyroid gland. The shape and measurements like length, breadth and thickness of both lobe of the gland were noted.Results: The mean values of all parameters by gestational age were calculated. In the present study, the weight of foetuses showed gradual increase from 10th week to 38th weeks of gestation. In the normally developing foetuses the thyroid gland dimension and its weight also increases with increase gestational age.Conclusion: There was no more difference between the dimension of right and left lobe of thyroid gland. The study provides morphological and morphometric knowledge on the development of foetal thyroid gland from 10th week to 38th weeks of gestation. The knowledge of thyroid gland weight and dimension and body weight in relation to the gestational age might be helpful to judge the thyroid structure in preterm babies.Asian Journal of Medical Sciences Vol.9(6) 2018 40-44

scholarly journals Normal value of pulsatility index of umbilical artery in second and third trimester of pregnancy

2013 ◽  
Vol 39 (1) ◽  
pp. 42-44 ◽  
Author(s):  
MA Ferdous ◽  
MM Sharif ◽  
AS Mohiuddin ◽  
F Shegufta
Keyword(s):  
Gestational Age ◽  
Pulsatility Index ◽  
Umbilical Artery ◽  
Negative Relationship ◽  
Cross Sectional Study ◽  
Third Trimester ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean ◽  
Level Of Significance

This cross sectional study was carried out on 60 pregnant Bangladeshi women in the department of Radiology and Imaging, BIRDEM for measurement of Pulsatility Index (PI) of umbilical artery of their fetuses by duplex colour Doppler sonography during 2nd and 3rd trimester of pregnancies. Considering total 2nd and 3rd trimesters the mean PI value of umbilical artery was 1.24 (SD±0.27). While considering the gestational in separate trimesters, study showed that the value of PI in 2nd trimester was 1.33 (SD±0.29) and in 3rd trimester PI was 1.18 (SD±0.25). Paired t test shows there was a highly significant (t=35.79, df=59, Level of significance=0.001) difference between mean values of PI in different gestational ages. It was observed that there was gradual decrease of PI value with increase of gestational age (r= -0.207) but this decrease of PI was not statistically significant (p=0.113). Regression analysis between dependent PI value and independent gestational age showed linear negative relationship but this was not statistically significant (p=0.11). This study revealed that the Pulsatility index of umbilical artery was decreased with increase of gestational age from 2nd to 3rd trimester. DOI: http://dx.doi.org/10.3329/bmrcb.v39i1.15809 Bangladesh Med Res Counc Bull 2013; 39: 42-44

Calcium and metabolism of I131 in rats and homogenates of rat thyroid

1961 ◽  
Vol 200 (5) ◽  
pp. 1023-1026 ◽  
Author(s):  
Yaro Ribeiro Gandra ◽  
John G. Coniglio
Keyword(s):  
Thyroid Tissue ◽  
Iodine Content ◽  
In Vitro Studies ◽  
Iodine Uptake ◽  
Total Iodine ◽  
Organic Iodine ◽  
Free Iodine ◽  
Inorganic Iodine ◽  
Rat Thyroid

The goitrogenic effect of calcium was studied by the use of I131 in intact rats and in rat thyroid slices. Rats receiving excess dietary calcium had larger thyroids than controls. Enlargement of the thyroid was accompanied by increased content of inorganic iodine and decreased content of organic iodine. In vitro studies showed that thyroid enlargement was associated with greater total iodine uptake. Addition of calcium to the incubation medium decreased the total iodine uptake of thyroid slices. The reduction occurred as a consequence of interference with the conversion of inorganic iodine to organic iodine. No decrease in inorganic iodine content was observed. The ratios of bound iodine to free iodine were constantly smaller in the thyroid groups receiving calcium supplement. The results of the in vitro studies suggest that calcium interference is due, at least in part, to a direct effect on thyroid tissue.

LABORATORY TESTS OF THYROID FUNCTION IN HYPERTHYROIDISM I.

1969 ◽  
Vol 62 (4_Suppla) ◽  
pp. S7-S21
Author(s):  
B.-A. Lamberg ◽  
O. P. Heinonen ◽  
M. Viherkoski ◽  
A. Aro ◽  
K. Liewendahl ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Laboratory Tests ◽  
Laboratory Data ◽  
Free Thyroxine ◽  
Clinical Severity ◽  
Hormone Concentration ◽  
Mean Values ◽  
Significant Difference ◽  
Thyroid Uptake ◽  
The Mean

ABSTRACT For the elaboration of a computer programme for the diagnosis of thyroid diseases the pattern of the results of laboratory tests was studied after dividing 125 hyperthyroid patients into different clinical entities and further also according to the severity of the hyperfunction of the thyroid gland. Comparison of variables was made between different clinical entities and, within these, between different grades of severity. All these groups were compared with the controls. Furthermore, the correlation between the results of laboratory tests was studied. The patients were divided into the following groups: toxic diffuse goitre (TDG; 50 cases), toxic multinodular goitre (TNG; 52 cases) and toxic adenoma (TA; 23 cases), and according to clinical severity of hyperfunction of the thyroid gland, into the following grades: »borderline» (I; 16 cases), mild (II; 35 cases) and moderate to severe (III; 74 cases). The laboratory tests studied were: protein-bound iodine in the serum (PBI), uptake of triiodothyronine by Sephadex (T3U), »free thyroxine index» (T3I), free proportionate and absolute thyroxine (PFT4, AFT4), serum cholesterol, serum and urinary hydroxyproline (HOP), glucose-6-phosphate dehydrogenase activity in red blood cells (G-6-PD), 2.5 h and 24 h thyroid uptake of radioiodine, 24 and 48 h urinary excretion, protein-bound radioactive iodine in the blood (PBRI) and the 24 h conversion ratio (CR). There was a statistically significant difference between TDG and TNG with regard to the thyroid uptake of radioiodine and the free thyroxine, the mean values being lower in the latter group of patients. The TA group differed significantly from the combined TDG-TNG group, the mean values deviating towards the normal range. The TA group did not differ from the controls with regard to PFT4, cholesterol and E0–24. This group evidently represented a separate population. In the TDG and TNG groups the laboratory data correlated well with the clinical assessment of severity. In most cases the differences were statistically significant. Grade I, however, differed from the controls only with respect to the variables of the hormone concentration in the blood. The variables of the measurement of hormone concentration in the blood had a strong linear correlation (r = 0.6—0.9) to each other and to the 2.5 h uptake. A significant correlation (r = 0.5—0.6) was also found between the variables mentioned and the urinary HOP and G-6-PD. The correlation between HOP and G-6-PD was of the same order. The fact that the pattern of PFT4—AFT4 and T3U—T3I differed may indicate variations in the ratios between triiodothyronine and thyroxine in different clinical entities of hyperthyroidism.

Direct measurement of gluconeogenesis from [2,3]13C2]alanine in the human neonate

1981 ◽  
Vol 240 (6) ◽  
pp. E615-E621 ◽  
Author(s):  
T. E. Frazer ◽  
I. E. Karl ◽  
L. S. Hillman ◽  
D. M. Bier
Keyword(s):  
Blood Glucose ◽  
Gestational Age ◽  
Constant Infusion ◽  
Postnatal Life ◽  
Term Infants ◽  
Intrauterine Growth ◽  
Human Newborn ◽  
Human Neonate ◽  
Appropriate For Gestational Age

The functional integrity of the gluconeogenic pathway was measured in nine term infants, four appropriate-for-gestational age (AGA), and five normoglycemic small-for-gestational age (SGA), by determination of 13C2 enrichment in blood glucose during the constant infusion of tracer [2,3]13C2]alanine between 4 and 8 h of postnatal age. Alanine flux, calculated from the steady-state blood [2,3-13C2]alanine enrichment was 16.6 +/- 1.3 (SE) (mumol.kg-1.min-1 in the AGA infants and not statistically different from the value of 15.3 +/- 0.7 mumol.kg-1.min-1 in the SGA infants. Alanine flux did not correlate with blood alanine level in either group. By 6 h of age, the earliest sampling time, there was 13C2 enrichment of blood glucose in every infant studied, indicating that the gluconeogenic pathway was functionally intact by that time and implying that it was operative sooner. At 8 h of age, 9.3 +/- 2.3% of blood glucose was derived from alanine in the AGA group and 12.9 +/- 2.4% in the SGA group, values not statistically different. These data indicate that the term human newborn has a functional gluconeogenic pathway very early in postnatal life and that intrauterine growth retardation per se does not impair maturation of the system. Furthermore, the plasma alanine level alone is a poor index of gluconeogenic carbon flow in these infants.

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