Prevalence of aneuploidy and additional anatomic abnormalities in fetuses and neonates with cleft lip with or without cleft palate: a population-based study in Utah.

2001 ◽  
Vol 20 (11) ◽  
pp. 1175-1180 ◽  
Author(s):  
S J Walker ◽  
R H Ball ◽  
C J Babcook ◽  
M M Feldkamp
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Population Based ◽  
Population Based Study

Population-Based Study on the Practice of Breastfeeding in Children Born with Cleft Lip and Palate

2005 ◽  
Vol 42 (6) ◽  
pp. 687-693 ◽  
Author(s):  
Letícia W. Garcez ◽  
Elsa R. J. Giugliani
Keyword(s):  
Cleft Palate ◽  
Median Duration ◽  
Exclusive Breastfeeding ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Breastfeeding Duration ◽  
Porto Alegre ◽  
Initiation Rate ◽  
Population Based Study

Objective To investigate the practice of breastfeeding and related difficulties in children born in Porto Alegre, Brazil, with cleft lip, cleft palate, and cleft lip with cleft palate. Design Cohort, observational, and population-based study. Population and Sample Mothers of all children born in 2001 and 2002 with cleft lip and palate in the city of Porto Alegre, Brazil (n = 31), were interviewed in their homes. From the information collected, the frequencies of breastfeeding and exclusive breastfeeding in the first year of life were estimated and the median duration was computed according to the type of cleft. A descriptive analysis was used to study the difficulties. Main Indicators Initiation rate, pattern, duration, and difficulties of breastfeeding and exclusive breastfeeding. Results The initiation rate of breastfeeding was 100% and its median duration was 42.5 days. Exclusive breastfeeding was initiated by 67.7% of the sample and maintained for 15 days (median). The breastfeeding duration was significantly higher in the presence of cleft lip, being equal or even superior to (in the case of exclusive breastfeeding) the median of Porto Alegre's general population. The most frequently mentioned difficulties were weak suction, difficulty attaching to the breast, and breast milk escaping through the nostrils. Conclusions In spite of the diverse difficulties reported and the lack of professional support after discharge from the maternity wards, the initiation rate and the duration of breastfeeding of children with cleft lip and palate found in this study reinforce the theory that this malformation, especially cleft lip, is compatible with successful breastfeeding.

scholarly journals School performance for children with cleft lip and palate: a population-based study

2016 ◽  
Vol 43 (2) ◽  
pp. 222-231 ◽  
Author(s):  
J. C. Bell ◽  
C. Raynes-Greenow ◽  
R. Turner ◽  
C. Bower ◽  
A. Dodson ◽  
...  
Keyword(s):  
School Performance ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study

scholarly journals PAX9 and TGFB3 are linked to susceptibility to nonsyndromic cleft lip with or without cleft palate in the Japanese: population-based and family-based candidate gene analyses

2005 ◽  
Vol 51 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Eisaburo Ichikawa ◽  
Akira Watanabe ◽  
Yoko Nakano ◽  
Sadanori Akita ◽  
Akiyoshi Hirano ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Candidate Gene ◽  
Japanese Population ◽  
Cleft Lip ◽  
Population Based ◽  
Family Based

scholarly journals Effect of Cleft Lip With or Without Palate on Pediatric General and Dental Growth in Korea: a Nationwide Population-based Cohort Study

2021 ◽  
Author(s):  
Jeong Yeop Ryu ◽  
Tae Hyun Park ◽  
Joon Seok Lee ◽  
Jung Dug Yang ◽  
Ho Yun Chung ◽  
...  
Keyword(s):  
Head Circumference ◽  
Cleft Lip ◽  
Primary Teeth ◽  
Cleft Lip And Palate ◽  
Dental Treatment ◽  
Population Based ◽  
Population Based Study ◽  
The Status ◽  
Dental Screening ◽  
Lower Height

Abstract There are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children’s Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66–71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries.

scholarly journals Population-Based Study of Birth Prevalence and Factors Associated with Cleft Lip and/or Palate in Taiwan 2002–2009

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58690 ◽  
Author(s):  
Ruoh-Lih Lei ◽  
Huey-Shys Chen ◽  
Bao-Yuan Huang ◽  
Yueh-Chih Chen ◽  
Philip Kuo-Ting Chen ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Population Based ◽  
Population Based Study ◽  
Birth Prevalence ◽  
Factors Associated

Birth Defect Co-Occurrence Patterns Among Infants With Cleft Lip and/or Palate

2021 ◽  
pp. 105566562110100
Author(s):  
Maria Luisa Navarro Sanchez ◽  
Renata H. Benjamin ◽  
Laura E. Mitchell ◽  
Peter H. Langlois ◽  
Mark A. Canfield ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Birth Defects ◽  
Birth Defect ◽  
Cleft Lip ◽  
Population Based ◽  
Orofacial Clefts ◽  
Developmental Mechanisms ◽  
Using Data ◽  
Occurrence Patterns ◽  
Population Based Registry

Objective: To investigate 2- to 5-way patterns of defects co-occurring with orofacial clefts using data from a population-based registry. Design: We used data from the Texas Birth Defects Registry for deliveries between 1999 and 2014 to Texas residents, including 1884 cases with cleft palate (CP) and 5289 cases with cleft lip with or without cleft palate (CL±P) without a known syndrome. We identified patterns of defects co-occurring with CP and with CL±P observed more frequently than would be expected if these defects occurred independently. We calculated adjusted observed-to-expected ( O/ E) ratios to account for the known tendency of birth defects to cluster nonspecifically. Results: Among infants without a syndrome, 23% with CP and 21% with CL±P had at least 1 additional congenital anomaly. Several combinations of defects were observed much more often than expected. For example, the combination of CL±P, congenital hydrocephaly, anophthalmia, and other nose anomalies had an O/ E ratio of 605. For both CP and CL±P, co-occurrence patterns with the highest O/ E ratios involved craniofacial and brain abnormalities, and many included the skeletal, cardiovascular, and renal systems. Conclusions: The patterns of defects we observed co-occurring with clefts more often than expected may help improve our understanding of the relationships between multiple defects. Further work to better understand some of the top defect combinations could reveal new phenotypic subgroups and increase our knowledge of the developmental mechanisms that underlie the respective defects.

Associated Malformations in Infants With Cleft Lip and Palate: A Prospective, Population-based Study

PEDIATRICS ◽  
1997 ◽  
Vol 100 (2) ◽  
pp. 180-186 ◽  
Author(s):  
J. Milerad ◽  
O. Larson ◽  
C. Hagberg ◽  
M. Ideberg
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study ◽  
Associated Malformations

Asian Oral-Facial Cleft Birth Prevalence

2006 ◽  
Vol 43 (5) ◽  
pp. 580-589 ◽  
Author(s):  
Margaret E. Cooper ◽  
Jessica S. Ratay ◽  
Mary L. Marazita
Keyword(s):  
Literature Review ◽  
Cleft Palate ◽  
Live Birth ◽  
Cleft Lip ◽  
Population Based ◽  
Prevalence Rates ◽  
Birth Prevalence ◽  
Live Births ◽  
Asian Populations ◽  
Apparent Reason

Objective: To determine the clefting birth prevalence among Asian populations, specifically Chinese and Japanese, using raw counts from nonoverlapping published studies of Asian populations, and to investigate whether Asian clefting rates have been interpreted accurately as being up to twice the Caucasian rate. Design: A literature review of articles giving raw counts of clefting in Asian populations, primarily Japanese and Chinese. Main Outcome Measures: Where possible, clefts were identified by the patients’ ethnicity, country of origin, cleft type, syndromic status, and birth status. Results: Prevalence rates of cleft lip with or without cleft palate per 1000 live births are reported. Syndromic plus nonsyndromic cleft lip with or without cleft palate: Chinese, 1.30; Japanese, 1.34; Other Asian, 1.47; and total, 1.33. Nonsyndromic cleft lip with or without cleft palate: Chinese, 1.20; Japanese, 1.18; Other Asian, 1.22; and total, 1.19. Conclusions: Overall, Chinese and Japanese live birth prevalence rates for nonsyndromic cleft lip with or without cleft palate, based on the published reports of birth prevalence, are significantly lower than the oft-quoted rate of 2 per 1000 for Asians. The apparent reason for the discrepancy is that many published prevalence rates included all pregnancies (live births plus pregnancy losses) and do not distinguish between syndromic and nonsyndromic clefts or between cleft palate alone and cleft lip with or without cleft palate. These results demonstrate that it is extremely important for current population-based studies of clefts to include careful delineation of population groups, syndromes, cleft type, and birth status.

scholarly journals Folic acid supplements and risk for oral clefts in the newborn: a population-based study

2015 ◽  
Vol 114 (9) ◽  
pp. 1456-1463 ◽  
Author(s):  
Trude Gildestad ◽  
Tone Bjørge ◽  
Stein Emil Vollset ◽  
Kari Klungsøyr ◽  
Roy Miodini Nilsen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Population Based ◽  
Vitamin Supplement ◽  
Birth Registry ◽  
Oral Clefts ◽  
Birth Prevalence ◽  
Live Births ◽  
Relative Risks

AbstractResults from previous studies on maternal folic acid intake and infant oral clefts are inconclusive. The aim of the present study was to investigate the association between women’s use of folic acid and/or multivitamin supplements and the risk for oral cleft in the newborn. We used data from the Medical Birth Registry of Norway based on all births in Norway from 1999 to 2013. A total of 528 220 women had 880 568 pregnancies, resulting in 896 674 live births and stillbirths, of which 1623 had oral clefts (isolated oral clefts, n 1311; non-isolated oral clefts, n 312). Altogether, 21·5 % of women were vitamin supplement users before pregnancy. The birth prevalence of oral clefts was 1·81/1000 live births and stillbirths. Relative risks (RR) were estimated with log-binomial regression. For pregnancies with maternal use of vitamins, the adjusted RR for clefts overall was 0·90 (95 % CI 0·79, 1·04). The adjusted RR for cleft palate only (n 586) was 0·84 (95 % CI 0·66, 1·06) and that for cleft lip with or without cleft palate (n 1037) was 0·94 (95 % CI 0·79, 1·13). Associations were stronger for cleft cases that occurred in combination with other malformations (adjusted RR 0·63; 95 % CI 0·45, 0·88), although vitamin supplements provided no protection against isolated clefts (adjusted RR 0·98; 95 % CI 0·84, 1·15). In conclusion, our study demonstrates no statistically significant association between vitamin use and isolated oral clefts. However, we found lower risk for oral clefts that occurred in combination with other malformations.

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