scholarly journals Prevalence of Benign Breast Lesions, Epithelial Proliferations with or without Atypia in Calabar-A Retrospective Review

2019 ◽  
pp. 1-7
Author(s):  
G. A. Ebughe ◽  
T. I. Ugbem ◽  
D. E. Ushie ◽  
S. Effewongbe ◽  
J. E. Udosen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Trend Analysis ◽  
Teaching Hospital ◽  
Mammographic Screening ◽  
Premalignant Lesions ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Hospital Policy ◽  
Benign Breast Lesions ◽  
The University

Aims: The aim of this study is to find out the prevalence of benign breast lesions and proliferative lesions which are associated with increase risk of breast cancer. This is aimed at influencing the hospital policy on mammographic screening. Study Design: Descriptive retrospective study involving a trend analysis of benign breast lesion, proliferative analysed in the surgical pathology unit of the University of Calabar Teaching Hospital between 1st of January 2012 to October 31st 2014. Place and Duration of Study: Pathology Department of the University of Calabar Teaching Hospital. The study was carried out between March and April 2019. Methodology: Descriptive retrospective study of trend analysis of benign and proliferative breast lesions over the period with literature review. Results: Two hundred and seventeen 217 patients consisting of seven males and two hundred and ten females with a female: Male ratio of 1:0.04. Mean age was 26.4 ± 10.0 years, ranging from 10 to 70 years, with 21-30 (94, 43.5%), as the predominant age and less than 21 years (70, 32.4%) as the second common age group. Seventy four percent of (74%) of the breast lesions were benign non proliferative lesions while 26% were proliferative breast lesions. Of the proliferative lesions, five or 8.9% of the proliferative or 2.33% of the lesions were atypical ductal hyperplasia’s which have a high risk of progression to cancer. Conclusion: Proliferative breast lesions and the premalignant lesions of the breast are not commonly reported in Calabar. An upscale of population screening and mammographic services may improve their yield which will help prevent some invasive breast cancers.

201Tl Scintigraphy in the Evaluation of Palpable and Nonpalpable Breast Lesions: Correlation with Mammography and Ultrasonography

1997 ◽  
Vol 36 (08) ◽  
pp. 282-288 ◽  
Author(s):  
T. Atasever ◽  
A. Özdemir ◽  
I. Öznur ◽  
N. I. Karabacak ◽  
N. Gökçora ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
Lower Sensitivity ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Combined Use ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Benign Breast Lesions ◽  
Palpable Breast ◽  
Metastatic Sites

Summary Aim: Our goal was to determine the clinical usefulness of TI-201 to identify breast cancer in patients with suspicious breast lesions on clinical examination, and/or abnormal radiologic (mammography and/or ultrasonography) findings. Methods: TI-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of TI-201. Visual and semiquantitative interpretation was performed. Results: Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. TI-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by TI-201 scintigraphy. The smallest mass lesion detected by TI-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. TI-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed TI-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated TI-201. TI-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by TI-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58 ± 0.38 (mean ± SD) and 1.48 ± 0.32 (p >0.05), 1.87 ± 0.65 and 1.34 ± 0.20 (p<0.05) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). Conclusion: Overall, TI-201 scintigraphy was the most specific of the three methods and yielded favourable results in palpable breast cancers, while it showed lower sensitivity in nonpalpable cancers and axillary metastases. Combined use of TI-201 scintigraphy with mammography and US seems to be useful in difficult cases, such as dense breasts and indeterminate breast lesions.

scholarly journals Efficacy of FNAC in Diagnosis of Breast Lumps - A Retrospective Study

2021 ◽  
Vol 8 (9) ◽  
pp. 13-17
Author(s):  
Oankar Kumar Maurya ◽  
Richa . ◽  
Manohar Lal
Keyword(s):  
Retrospective Study ◽  
Diagnostic Accuracy ◽  
False Negative ◽  
Patient Acceptance ◽  
Breast Lesions ◽  
Main Role ◽  
Study Results ◽  
Malignant Lesions ◽  
Benign Breast Lesions ◽  
Breast Lumps

Background: FNAC is an established and highly accurate method for diagnosis of breast lesions. Its further advantage is to give rapid diagnosis, cost-effectiveness, excellent patient acceptance and minimal or no morbidity. The study aimed to diagnose various breast masses before operation by FNAC and to compare the result of FNAC with histopathological study to assess the efficacy of FNAC. Materials and Methods: The study entitled “Efficacy of FNAC in diagnosis of Breast Lumps” is a retrospective study conducted in department of surgery with collaboration of pathology department at Nalanda Medical College and Hospital, Patna during the period of July 2017 to December 2019. During this period, 150 FNAC cases were selected for study. Results: Fibroadenoma was the most commonly diagnosed entity in benign breast lesions, followed by fibrocystic disease. Among malignant lesions, infiltrating ductal carcinoma was the most common. The overall diagnostic accuracy of FNAC in benign breast lesions was 94.59%. The fibroadenomas were correctly diagnosed in 92.96% cases. There were 5.41% false negative results in our series. There was no false positive result giving specificity of 100%. Conclusion: FNAC is an inexpensive, simple, safe and readily acceptable procedure to the patient and plays main role to provide rapid and accurate diagnosis of breast lumps. FNAC enables us to differentiate benign from malignant lesions with high sensitivity, specificity and diagnostic accuracy. Keywords: Breast Lump, FNAC, HPE: Histopathological Examination.

scholarly journals Benign Proliferative Breast Disease: A Histopathological Review of Cases at Korle Bu Teaching Hospital

2020 ◽  
pp. 1-5
Author(s):  
Leonard Derkyi-Kwarteng ◽  
Ato A. Brown ◽  
Abigail Derkyi-Kwarteng ◽  
Eric Gyan ◽  
Kafui P. Akakpo ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Statistical Significance ◽  
Breast Disease ◽  
Left Breast ◽  
Breast Diseases ◽  
Breast Lesions ◽  
Tubular Adenoma ◽  
African Countries ◽  
Benign Breast Lesions ◽  
Ghanaian Women

Background:​ With the increasing education on breast cancer, most women are reporting to the hospital with breast lumps most of which are benign breast lesions. Benign breast diseases constitute a heterogeneous group of lesions including developmental abnormalities, inflammatory lesions, epithelial and stromal proliferation and neoplasms. This is to look at the various histologic type of benign proliferative breast diseases among Ghanaian women. Method​s: This is a retrospective study of breast excisions received between 2006-2013 at the Department of Pathology, Korle Bu teaching hospital (KBTH), Ghana. All histological slides were retrieved and examine. Demographic information was also retrieved from the request form. The data was subject to analysis using SPSS version 16.5 and Windows Excel. Results​: During the period of study, 2,805 cases of benign breast lesions were received by the department, out of which 2,396 were proliferative benign lesions representing 89.4%. The top five lesions were fibroadenoma (89.01%), fibroadenomatoid hyperplasia (3.26%), tubular adenoma (2.51%), benign phylloides tumour (1.71%) and intraductal papilloma (1.59%). The average ages of clients with these lesions were 24 years (±8.3 years), 28 years (±10.7 years), 22.7 years (±15 years), 38 years (±14.2 years and 45.4 years (±8.3 years) respectively. Fibroadenoma and benign phelloides tumour have a preponderance to the right and left breast respectively with statistical significance. Conclusion​: There are some differences between benign breast lesions in Ghanaian women as compared to other African countries within the Sub Saharan region.

scholarly journals A 5-year Retrospective Study on Alopecia in a Tertiary Hospital in Southern Nigeria

2020 ◽  
Vol 8 (3) ◽  
pp. 175-182
Author(s):  
C.R. Madubuko ◽  
B.U. Okwara
Keyword(s):  
Retrospective Study ◽  
Teaching Hospital ◽  
Hair Loss ◽  
Lupus Erythematosus ◽  
Tertiary Hospital ◽  
Discoid Lupus Erythematosus ◽  
Female Ratio ◽  
Benin City ◽  
The University ◽  
Étude Rétrospective

Background: Alopecia is a common condition accounting for the top ten morbidities seen in patients that present at dermatology outpatient clinics in Nigeria.Aim: This retrospective study aimed at documenting the prevalence and types of alopecia in the skin clinic at the University of Benin Teaching Hospital between December 2014 and December 2019. Methods: The medical records of all patients with alopecia attending dermatological outpatient clinic between December 2014 to December 2019 were analyzed retrospectively for this descriptive observational study. An approval for the study was obtained from the Ethics Committee of the University of Benin Teaching Hospital, Benin-city, Nigeria. The diagnosis of Hair loss was essentially clinical, confirmed where expedient with a skin biopsy. Dermatological tools like Dermoscopes were also used to boost diagnostic accuracy when necessary. The patients were also evaluated for presence of other cutaneous and systemic disorders. Results: During the 5year study period, 106 patients with hair loss (6.6%%) were observed. The youngest patient was 2months old and the oldest patient was 90years old. The males constituted 61.3% of patients observed while the females accounted for 38.7% of patients seen. The male to female ratio was 1.6:1. Discoid lupus erythematosus of the scalp, was the most common disorder 29(29.4%). Alopecia areata occurred in23(27.7%); tinea capitis in 15(14,2%); Acne keloidalis nuchae in 14(13.2%); seborrheic dermatitis10(9.4%); and folliculiltis delcavans 9(8.5%). Less commonly observed causes of alopecia included androgenetic alopecia 2(1.9%); traction alopecia 2(1.9%); lichenplanopilaris 1(0.9%) and nevus sebaceum 1(0.9%). Conclusion: There is a need for studies to further describe and proffer solutions to common causes of alopecia in our community. Keywords: Retrospective study, Alopecia, Tertiary hospital, Benin French title: Une étude rétrospective de cinq (5) ans sur l'alopécie dans un hôpital tertiaire du Sud au Nigéria Contexte général de l'étude: L'alopécie est une condition de classement courante qui explique les dix principales morbidités observées chez les patients qui se présentent dans des cliniques externes de dermatologie au Nigéria.Objectif de l'étude: Cette étude rétrospective visait à documenter la prévalence et les types d'alopécie à la clinique externe de dermatologie de l'hôpital universitaire du Bénin entre décembre 2014 et décembre 2019.Méthode de l'étude: Il s'agissait d'une étude rétrospective de patients présentant principalement une perte de cheveux. Les données ont été obtenues à partir des dossiers cliniques et des notes cliniques des patients.Résultats de l'étude: Au cours de la période d'étude de 5 ans, 106 patients sur 1 600 personnes fréquentant la clinique de la peau ont eu une perte de cheveux constituant une prévalence de 6,6%. Les patients vus étaient âgés de 2 mois à 90 ans. Plus d'hommes (61,3%) que de femmes (38,7%) ont été vus; avec un rapport de 1,6: 1. Le lupus érythémateux discoïde du cuir chevelu était le trouble le plus courant «insérer un nombre absolu» (29,4%). L'alopécie areata est survenue en «insérer le nombre absolu» 27,7%; tineacapitis en «insérer le nombre absolu» 14,2%; Acné  keloidalisnuchae en «insérer le nombre absolu» 13,2%; dermatite séborrhéique «insérer le nombre absolu» 9,4%; et folliculiltisdelcavans «insérer le nombre absolu» 8,5%. Les causes d'alopécie moins fréquemment observées comprenaient l'androgénétopécie (1,9%); alopécie de traction (1,9%); lichenplanopilaris (0,9%) et naevus sébacé (0,9%)Conclusion: Des études sont nécessaires pour décrire et proposer des solutions aux causes courantes d'alopécie dans notre communauté. Mots-clés: Alopécie, lupus érythémateux discoïde, alopéciaareata, acné keloidalisnuchae

scholarly journals Cancer in Cross River State

2019 ◽  
pp. 1-8
Author(s):  
G. A. Ebughe ◽  
T. I. Ugbem ◽  
D. E. Ushie ◽  
S. Effewongbe
Keyword(s):  
Trend Analysis ◽  
Cancer Registry ◽  
Teaching Hospital ◽  
Population Based ◽  
Capital City ◽  
Hospital Data ◽  
Cross River ◽  
Cross River State ◽  
Cancer Data ◽  
The University

Aims: To determine the prevalence of cancer in the rest of Cross River State not covered by the population-based cancer registry which is limited to the capital city of Calabar. Study Design: Descriptive retrospective study involving a trend analysis of cancers from the rest of Cross River State not covered by the Calabar cancer registry. Cancers incident in the Pathology and Haematology departments of the University of Calabar Teaching hospital are included in the study. Place and Duration of Study: Pathology and Haematology departments of the University of Calabar Teaching hospital. Data was assessed between April to May 2019. Methodology: An institution-based trend analysis of cancers originating from the rest of Cross River State, out of population-based cancer registry’s coverage was carried out. Such cases incident in the Pathology and Hematology Departments of the University of Calabar Teaching Hospital were included. Cancer data from 1st January 2004 to 31st December 2013 was accessed from the archives of both departments. Data extraction was carried out though filling of a check list and these were fed into IBM statistical package for social sciences SPSS version 21 for analysis. Results: Nine hundred and fourty one (941), cancer cases were diagnosed during this period. The mean age of diagnosis was 49.18 ± 18.9.Four hundred and seventy seven (477 or 50.69%) females and 464 or 49.31% males had cancer, representing a female to male ratio 0.97: 1. Overall, the commonest age group was 40 to 64 years (46.3%), followed by 18 to 39 years (25.5%), and 65 years or greater (23.0%).Breast cancer followed by prostate cancer were the commonest cancers in adults, while cancers in the lymphohaematopoietic tissue, soft tissue and eye were the commonest in children. Conclusion: Cancer occurs at an earlier age in the rest of Cross River State, with breast and prostatic cancer dominating. Efforts should be doubled to institute effective screening programmes.

scholarly journals The Pattern of Cancer Cases in the Rest of Cross River State Not Covered by the Calabar Cancer Registry between 2004 and 2013

2019 ◽  
pp. 1-12
Author(s):  
G. A. Ebughe ◽  
M. A. Inyama ◽  
T. I. Ugbem ◽  
D. E. Ushie
Keyword(s):  
Soft Tissue ◽  
Trend Analysis ◽  
Cancer Registry ◽  
Teaching Hospital ◽  
Age Groups ◽  
Cross River ◽  
Cross River State ◽  
The University ◽  
Age Range ◽  
Prevalence Of Cancer

Aims: This study aims to find out the prevalence of cancer in the different age groups in the rest of Cross River state not covered by the Calabar cancer registry. Study Design: Descriptive retrospective study involving a trend analysis of the cancers incident in the University of Calabar Teaching Hospital, and persons from the rest of Cross River State not covered by the Calabar cancer registry. Such cases as occurred between 1st of January 2004 to December 31st, 2013 were included. Place and Duration of Study: The Department of Pathology, University of Calabar Teaching hospital; between April and May 2019. Methodology: A trend analysis of cancer cases from the rest of Cross River State outside the range of the Calabar cancer registry over the period was studied. Results: Nine hundred and forty-one (941) cases of cancer were seen outside Calabar in Cross River State, within January 2004 and December 2013. Mean age was 49.18 ± 18.9 years, ranging from 1 to 100 years, and female: male ratio was 1: 0.97. The commonest age range cancer occurred is 40 to 64 years overall, 40 to 64 years in males and 40 to 64 years in females. The commonest cancers sites were breast cancer (21.9%), prostate (21.3%), lymphohematopoietic (9.2%). The commonest cancers in males were prostate (43.1), lymphohematopoietic (12.9%), soft tissue (11.4%). In females' breast 41.1% and cervix, 15.9% were the dominant sites. Cancer in the 0 to 17 age range was remarkably similar and was dominated by lymphohematopoietic sites, soft tissue, eye and urinary system. Cancer in the older ages 65 years and above is overwhelmingly dominated by prostate 60% followed by breast 18%. Conclusion: Cancer in the rest of Cross River State is dominated by breast, prostate and cervical sites. This is like the GLOBOCAN estimates for Nigeria.

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