scholarly journals Predictors and Protectors of Pathological Menopause

2019 ◽  
pp. 1-8
Author(s):  
Dilrabo T. Kayumova
Keyword(s):  
Diabetes Mellitus ◽  
Higher Education ◽  
Metabolic Syndrome ◽  
Medical Education ◽  
Uterine Fibroids ◽  
Menopausal Syndrome ◽  
The Metabolic Syndrome ◽  
Metabolic Imbalance ◽  
Main Components ◽  
A Prospective Study

A prospective study of 1484 women aged 35-70 years was conducted, which were divided into 3 groups - late reproductive, perimenopausal and postmenopausal. Menopausal syndrome (MS) was detected in 1369 (93.3%) women. Every third woman in peri- and postmenopause had a moderately severe MS. The metabolic imbalance worsened more as the severity of the MS increased, rather than with increasing age. Predictors of pathological menopause are identified - these are the main components of the metabolic syndrome (diabetes mellitus, hypertension, obesity); uterine fibroids, as well as urbanization and higher education. The protective factors for the development of the MS was the absence of the fact of marriage (single), medical education and waist circumference of 80 cm or less.Late reproductive stage

scholarly journals COVID-19 in persons with diabetes mellitus and obesity in a cluster of metabolic syndrome

2021 ◽  
pp. 102-106
Author(s):  
А.В. Хохлова ◽  
П.К. Бойченко ◽  
Д.С. Пархомчук ◽  
А.А. Востриков
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Mortality Rate ◽  
Viral Infection ◽  
Current Issue ◽  
Obese Patients ◽  
The Metabolic Syndrome ◽  
Healthcare It ◽  
Main Components ◽  
A Current

Пандемия новой коронавирусной инфекции COVID-19, вызванная вирусом SARS-CoV-2 является актуальнейшей проблемой как отечественного, так и мирового здравоохранения. На сегодня уже установлено, что при данной вирусной инфекции наиболее уязвимыми с выраженным тяжелым течением и высокой летальностью являются лица, имеющие различные хронические заболевания, в том числе сахарный диабет (СД) и ожирение, которые выступают основными компонентами метаболического синдрома (МС). В статье обсуждаются: эпидемиология, патогенез, наиболее распространенные симптомы заболевания, а также особенности течения COVID-19 у лиц с ожирением и СД. The new coronavirus COVID-19 pandemic caused by the SARS-CoV-2 virus is a current issue for both national and international healthcare. It has already been established that those most vulnerable to this viral infection have a pronounced, severe course and high mortality rate. These are patients with various chronic diseases, including diabetes mellitus (DM) and obesity, which are the main components of the metabolic syndrome (MS). This article describes the epidemiology, the pathogenesis, the most common symptoms, and the characteristics of COVID-19 in obese patients with DM.

Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib

2017 ◽  
Vol 36 (1) ◽  
pp. 78-88 ◽  
Author(s):  
Christian Labenz ◽  
Vera Prenosil ◽  
Sandra Koch ◽  
Yvonne Huber ◽  
Jens U. Marquardt ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Metabolic Syndrome ◽  
Group Performance ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Advanced Hepatocellular Carcinoma ◽  
Advanced Hcc ◽  
The Metabolic Syndrome ◽  
The Impact

Background/Aim: Individual components of the metabolic syndrome (MS) such as obesity or diabetes mellitus impair the prognosis of patients with hepatocellular carcinoma (HCC) following curative treatment approaches or transarterial therapies. The aim of this retrospective study was to assess the impact of these factors on the overall survival (OS) of patients with advanced HCC treated with sorafenib. Methods: Univariate and multivariate analyses were performed to assess the impact of individual components of the MS on the OS of 152 consecutive patients with advanced HCC treated with sorafenib. Results: The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS. Multivariate analysis showed that Eastern Cooperative Oncology Group Performance Status ≥1 (hazards ratio [HR] 2.03), presence of macrovascular invasion (HR 1.71), Child-Pugh score B/C (HR 2.19), tumor grading G3 (HR 2.17), no prior HCC treatment (HR 2.34), and the presence of 2 or more out of 5 individual components of the MS (HR 0.65) were independent prognostic factors regarding the median OS. Conclusions: Our investigations do not confirm a negative prognostic role of individual components of the MS or the MS itself for patients with advanced HCC treated with sorafenib.

scholarly journals Advantages of therapy with sodium glucose cotransporter type 2 inhibitors in patients with type 2 diabetes mellitus in combination with hyperuricemia and gout

2020 ◽  
Vol 92 (5) ◽  
pp. 110-118 ◽  
Author(s):  
T. S. Panevin ◽  
M. S. Eliseev ◽  
M. V. Shestakova ◽  
E. L. Nasonov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
New Drugs ◽  
Positive Effects ◽  
The Metabolic Syndrome ◽  
Sodium Glucose Cotransporter ◽  
The Russian Federation

Currently, only two drugs for reducing uric acid (UA), allopurinol and febuxostat, are registered in the Russian Federation, but their use does not allow to achieve the target level of UA in all cases. According to the results of numerous randomized trials, hyperuricemia and gout are associated with the corresponding components of the metabolic syndrome, including diabetes mellitus. The influence of factors is due to the need to search for new drugs that have a complex effect on several components of metabolic syndrome at once. Potentially attractive in this regard is a new group of drugs for the treatment of type 2 diabetes mellitus inhibitors of the sodium-glucose cotransporter of type 2, which, in addition to the main hypoglycemic actions, showed positive effects on the cardiovascular system, kidneys, as well as lowering UA.

scholarly journals The Effects of Changes in the Metabolic Syndrome Detection Status on Arterial Stiffening: A Prospective Study

2006 ◽  
Vol 29 (9) ◽  
pp. 673-678 ◽  
Author(s):  
Hirofumi TOMIYAMA ◽  
Yoji HIRAYAMA ◽  
Hideki HASHIMOTO ◽  
Minoru YAMBE ◽  
Jiko YAMADA ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Prospective Study ◽  
Arterial Stiffening ◽  
The Metabolic Syndrome ◽  
A Prospective Study
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