scholarly journals Comparative Study of Native or Nano Quercetin on Epigenetic Modification and Nephropathy Biomarkers Post Challenges in Diabetic Hamsters

2021 ◽  
pp. 140-153
Author(s):  
Soha Shebel Nassar ◽  
Mona Ahmed Sadek ◽  
Huda Mohamed Ismail ◽  
Gehan Salah El-Din Moram
Keyword(s):  
Gene Expression ◽  
Epigenetic Modification ◽  
Inflammatory Biomarkers ◽  
Synthesis And Characterization ◽  
Male Adult ◽  
Pathologic Condition ◽  
Biochemical Pathways ◽  
Healthy Control ◽  
Regulatory Effects

Aims: The aim of this study is to examine the regulatory effects of quercetin nanoparticles (QNPs) compared with native quercetin either with or without metformin against the abnormal molecular and biochemical pathways that eventually culminate in the pathologic condition clinically known as diabetic nephropathy (DN) in hamsters Methodology: After synthesis and characterization of the QNPs, seventy male adult hamsters are divided as following; G1:healthy control, G2:untreated DN hamsters, G3:DN+metformin G4:DN+native quercetin, G5:DN+QNPs, G6:DN+native quercetin+ metformin and G7: DN + QNPs + metformin. Results: Our results illustrated that the effect of QNPs + metformin is the most effective in IRS-1 and GLUT-4 gene expression that correlated with inhibition of HDACs which in turn improved diabetic and nephropathy biomarkers, this effectiveness followed by G6 then   G3 and finally G4 after G5. These results were confirmed by immunohistochemical  examinations. Levels of antioxidant and inflammatory biomarkers also reflected the protective effect of our treatments. Conclusion: All tested treatments significantly exhibit renal improvement.

Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two-Photon-Sensitive Photoremovable Groups Suitable for Light-Induced Gene Expression

ChemBioChem ◽  
2018 ◽  
Vol 19 (12) ◽  
pp. 1341-1348
Author(s):  
Bastien Goegan ◽  
Firat Terzi ◽  
Frédéric Bolze ◽  
Sidney Cambridge ◽  
Alexandre Specht
Keyword(s):  
Gene Expression ◽  
Synthesis And Characterization ◽  
Two Photon

Synthesis and Characterization of a New Bioactivated Paramagnetic Gadolinium(III) Complex [Gd(DOTA-FPG)(H2O)] for Tracing Gene Expression

2007 ◽  
Vol 18 (6) ◽  
pp. 1716-1727 ◽  
Author(s):  
Yu-Ton Chang ◽  
Chiu-Min Cheng ◽  
Yu-Zheng Su ◽  
Wei-Thung Lee ◽  
Jui-Sheng Hsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synthesis And Characterization

scholarly journals Characterization of Changes in Gene Expression and Biochemical Pathways at Low Levels of Benzene Exposure

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e91828 ◽  
Author(s):  
Reuben Thomas ◽  
Alan E. Hubbard ◽  
Cliona M. McHale ◽  
Luoping Zhang ◽  
Stephen M. Rappaport ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benzene Exposure ◽  
Biochemical Pathways ◽  
Low Levels

Synthesis and Characterization of a C(6) Nucleoside Analogue for thein vivo Imaging of the Gene Expression ofHerpes Simplex Virus Type-1 Thymidine Kinase (HSV1 TK)

2006 ◽  
Vol 3 (3) ◽  
pp. 274-283 ◽  
Author(s):  
Anass Johayem ◽  
Silvana Raić-Malić ◽  
Katia Lazzati ◽  
Pius A. Schubiger ◽  
Leonardo Scapozza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thymidine Kinase ◽  
Virus Type ◽  
Nucleoside Analogue ◽  
Synthesis And Characterization ◽  
Simplex Virus

Synthesis and Characterization of the Three Dicyclopentapyrenes

1996 ◽  
Vol 61 (10) ◽  
pp. 3572-3572
Author(s):  
Lawrence T. Scott ◽  
Atena Necula
Keyword(s):  
Synthesis And Characterization

Synthesis and characterization of TiN / Ti / AISI 410 coatings

2018 ◽  
Vol 2 (1) ◽  
pp. 7
Author(s):  
S Chirino ◽  
Jaime Diaz ◽  
N Monteblanco ◽  
E Valderrama
Keyword(s):  
Synthesis And Characterization ◽  
Photoemission Spectroscopy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Columnar Grains ◽  
Tin Thin Films ◽  
Steel Aisi ◽  
Interacting Surfaces ◽  
Stainless Steel Aisi

The synthesis and characterization of Ti and TiN thin films of different thicknesses was carried out on a martensitic stainless steel AISI 410 substrate used for tool manufacturing. The mechanical parameters between the interacting surfaces such as thickness, adhesion and hardness were measured. By means of the scanning electron microscope (SEM) the superficial morphology of the Ti/TiN interface was observed, finding that the growth was of columnar grains and by means of EDAX the existence of titanium was verified.  Using X-ray diffraction (XRD) it was possible to observe the presence of residual stresses (~ -3.1 GPa) due to the different crystalline phases in the coating. Under X-ray photoemission spectroscopy (XPS) it was possible to observe the molecular chemical composition of the coating surface, being Ti-N, Ti-N-O and Ti-O the predominant ones.

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