Clozapine-associated renal failure: A case report and literature review

Abstract One of clozapine's unrecognized potential side effects is renal insufficiency and nephritis. Although most clinicians are aware of the possibility of clozapine-induced myocarditis, less is known about other inflammatory disorders due to clozapine treatment. This patient was started on lithium and clozapine within 4 days of each other although lithium was discontinued after 7 days due to tremor. Routine labs showed an increase in serum creatinine, which was initially attributed to the recent lithium. However, the patient's kidney function continued to worsen, requiring discontinuation of clozapine despite a robust response to a low dose. Several years later, the patient's kidney function improved but has not returned to baseline. This literature review and case report illustrates the similarities in diagnostic presentation of clozapine-associated renal insufficiency as well as potential risk factors. More research should be conducted into the role concomitant sodium valproate and/or lithium play in the risk of clozapine-associated renal insufficiency.

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Single low dose baclofen induced encephalopathy in patient with renal failure – case report with literature review

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.118612 ◽

2021 ◽

Vol 429 ◽

pp. 118612

Author(s):

Rabia Muddassir

Keyword(s):

Renal Failure ◽

Case Report ◽

Literature Review ◽

Low Dose

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Severe Tachycardia Following Low-Dose Clozapine Treatment

Australasian Psychiatry ◽

10.1080/j.1440-1665.2004.02156.x ◽

2005 ◽

Vol 13 (1) ◽

pp. 80-82 ◽

Cited By ~ 5

Author(s):

Hans Stampfer ◽

Peter Swanepoel

Keyword(s):

Heart Rate ◽

Adverse Drug Reaction ◽

Drug Reaction ◽

Case Report ◽

Low Dose ◽

Reaction Probability ◽

Probability Scale ◽

Clozapine Treatment ◽

Probable Relationship ◽

Clinical Detection

Objective: To reporta case of severe and sustained tachycardia that developed asymptomatically on a low dose of clozapine (ISO mg daily). Method: Case report. Results: Serially monitored 24 h heart rate after the introduction of clozapine showed an increase in the 24 h mean from 87 to 126 bpm, a reduction of pulse variability and anomalies in sleep-wake regulation. Cessation of clozapine was followed by a rapid return to preclozapine activity. Application of the Naranjo Adverse Drug Reaction Probability Scale indicated a probable relationship between clozapine and the sustained tachycardia. Conclusions: Severe and sustained tachycardia can develop asymptomatically with a relatively low dose of clozapine and a slow titration rate. The severity of the tachycardia may not be revealed in isolated pulse measurements and may escape clinical detection without closer monitoring of heart rate.

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Analysis of seizure risk factors after allogeneic hematopoietic stem cell transplantation: A 8 case report and literature review

Journal of Huazhong University of Science and Technology [Medical Sciences] ◽

10.1007/s11596-013-1176-x ◽

2013 ◽

Vol 33 (5) ◽

pp. 656-660 ◽

Cited By ~ 4

Author(s):

Zhao-dong Zhong ◽

Lei Li ◽

Yao-hui Wu ◽

Yong You ◽

Wei-ming Li ◽

...

Keyword(s):

Risk Factors ◽

Stem Cell ◽

Case Report ◽

Hematopoietic Stem Cell Transplantation ◽

Literature Review ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Hematopoietic Stem

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Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report

BMC Pharmacology and Toxicology ◽

10.1186/s40360-020-00421-6 ◽

2020 ◽

Vol 21 (1) ◽

Cited By ~ 2

Author(s):

Qian Xiang ◽

Zhiyan Liu ◽

Yanyan Yu ◽

Hanxu Zhang ◽

Qiufen Xie ◽

...

Keyword(s):

Renal Failure ◽

Case Report ◽

Adefovir Dipivoxil ◽

Fanconi Syndrome ◽

Low Dose

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Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1914 ◽

2016 ◽

Vol 17 (8) ◽

pp. 692-701 ◽

Cited By ~ 16

Author(s):

Farzaneh Agha-Hosseini ◽

Nafiseh Sheykhbahaei ◽

Maryam-Sadat SadrZadeh-Afshar

Keyword(s):

Risk Factors ◽

Literature Review ◽

Malignant Transformation ◽

Lichen Planus ◽

Potential Risk ◽

Oral Lichen Planus ◽

World Health ◽

Extensive Literature ◽

Potential Risk Factors ◽

Oral Lichen

ABSTRACT Aim Many studies have suggested that a lesion originally diagnosed as oral lichen planus (OLP) has different possibilities of undergoing malignant transformation in time, although these findings remain a controversial issue; for example, some studies reported different values of potential malignancy of OLP. Introduction World Health Organization (WHO) classifies OLP as a “potentially malignant disorder” with unspecified malignant transformation risk, and suggests that OLP patients should be closely monitored. Numerous studies have attempted to confirm the malignant transformation potential of OLP. Review results The Cochrane Controlled Trials Register, Medline and EMBASE databases, PubMed, Google Scholar, Ovid, Up To Date, BMJ Clinical Evidence, MD Consult, and Science Direct were searched for papers published between 1997 and 2015. The medical subject heading search terms were “lichen planus,” “oral lichen planus,” “erosive oral lichen planus,” “dysplasia,” “oral precancerous condition,” “oral premalignant condition,” oral cancer, oral squamous cell carcinoma (OSCC), and atrophic lichen planus. A total of 120 English language abstracts were reviewed, and 50 relevant articles identified. Because of the extensive literature on the association between OLP and SCC, we have divided the data into genetic and nongenetic factors for more accurate assessment. Conclusion In this evidence base, malignant transformation ranges from 0 to 37% with a mean of 4.59%. The highest rate of malignancy was noted in erythematosus and erosive lesions. In this way, follow-up of OLP patients could be carried out more efficiently and appropriately. Clinical significance Oral lichen planus is a premalignant lesion. All types of OLP in any site of oral mucosa must be monitored regularly. How to cite this article Agha-Hosseini F, Sheykhbahaei N, SadrZadeh-Afshar M-S. Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review. J Contemp Dent Pract 2016;17(8):692-701.

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