scholarly journals Therapeutic Stomatocytes with Aggregation Induced Emission for Intracellular Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1833
Author(s):  
Jingxin Shao ◽  
Shoupeng Cao ◽  
Hanglong Wu ◽  
Loai Abdelmohsen ◽  
Jan van Hest
Keyword(s):  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Oxygen Species ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Aggregation Induced Emission ◽  
Poly Ethylene ◽  
Controllable Size

Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability. In this contribution, we developed well-defined therapeutically active stomatocytes with aggregation-induced emission (AIE) features by self-assembly of biodegradable amphiphilic block copolymers, comprising poly(ethylene glycol) (PEG) and AIEgenic poly(trimethylene carbonate) (PTMC) moieties. The presence of the AIEgens endowed the as-prepared stomatocytes with intrinsic fluorescence, which was employed for imaging of cellular uptake of the particles. It simultaneously enabled the photo-mediated generation of reactive oxygen species (ROS) for photodynamic therapy. The potential of the therapeutic stomatocytes as cargo carriers was demonstrated by loading enzymes (catalase and glucose oxidase) in the nanocavity, followed by a cross-linking reaction to achieve stable encapsulation. This provided the particles with a robust motile function, which further strengthened their therapeutic effect. With these unique features, enzyme-loaded AIEgenic stomatocytes are an attractive platform to be exploited in the field of nanomedicine.

A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability

2018 ◽  
Vol 6 (7) ◽  
pp. 1076-1084 ◽  
Author(s):  
Long Xu ◽  
Yidi Yang ◽  
Mingying Zhao ◽  
Wenxia Gao ◽  
Hai Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery Systems ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Stimuli Responsive ◽  
Poly Ethylene Glycol ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug ◽  
Poly Ethylene ◽  
Polymeric Drug Delivery Systems

Stimuli-responsive polymeric drug delivery systems are of great interest in anticancer research. Here, a reactive oxygen species (ROS)–responsive prodrug was prepared by thioketal linkage of poly(ethylene glycol) (PEG) and the anticancer drug doxorubicin (DOX).

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Hierarchical Self-Assembly of Microgel-Modified Biomaterials Surfaces

2014 ◽  
Vol 1622 ◽  
pp. 1-6
Author(s):  
Yong Wu ◽  
Jing Liang ◽  
Qichen Wang ◽  
Matthew Libera
Keyword(s):  
Self Assembly ◽  
Scale Effects ◽  
Control Surface ◽  
Poly Ethylene Glycol ◽  
Hydrogel Particles ◽  
Network Properties ◽  
Tissue Cells ◽  
Poly Ethylene ◽  
Non Line Of Sight

ABSTRACTMicrogels are hydrogel particles with micron and sub-micron diameters. They have beendeveloped, studied, and exploited for a broad range of applications because of their uniquecombination of size, soft mechanical properties, and controllable network properties. We havebeen using microgels to modulate the properties of surfaces to differentially control theirinteractions with tissue cells and bacteria. The long-term goal is to create biomaterials thatpromote healing while simultaneously inhibiting infection. Because poly(ethylene glycol) [PEG]is used in a number of FDA-approved products and has well-known antifouling properties, wework primarily with PEG-based microgels. We render these anionic either by copolymerizationwith monomeric acids or by blending with polyacids. Both methods produce pH-dependentnegative charge. Surfaces, both planar 2-D surfaces as well as topographically complex 3-Dsurfaces, can be modified using a hierarchy of non-line-of-sight electrostatic depositionprocesses that create biomaterials surfaces whose cell adhesiveness is modulated by a submonolayerof microgels. Average inter-microgel spacings of 1-2 microns exploit naturaldifferences between staphylococcal bacteria and tissue cells, which open the opportunity todifferentially control surface interactions with them based on length-scale effects. Afterdeposition, the microgels can be loaded with a variety of small-molecule, cationic antimicrobials.The details of loading depend on the relative sizes of the antimicrobials and the microgelnetwork structure as well as on the amount and spatial distribution of electrostatic charge withinboth the microgel and on the antimicrobial. The exposed surface between microgels can befurther modified by the adsorption of adhesion-promoting proteins such as fibronectin viaelectrostatic interaction. This approach combines a rich interplay of microgel structure andchemistry as a key component in a simple and translatable approach to modulate the surfaceproperties of next-generation biomaterials.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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