Feature Extraction In Gene Expression Dataset Using Multilayer Perceptron

Numerous amount of gene expression datasets that are publicly available have accumulated since decades. It is hence essential to recognize and extract the instances in terms of quantitative and qualitative means.In this study, Keras is utilized to model the multilayer perceptron (MLP) to extract the features from the given input gene expression dataset. The MLP extracts the features from the test datasets after its initial training with the top extracted features from the training classifiers. Finally with the top extracted features, the MLP is fine tuned to extract optimal features from the gene expression datasets namely Gene Expression database of Normal and Tumor tissues 2 (GENT2). The experimental results shows that the proposed model achieves better feature selection than other methods in terms of accuracy, f-measure, precision and recall.

The mouse Gene Expression Database (GXD): 2021 update

The Gene Expression Database (GXD; www.informatics.jax.org/expression.shtml) is an extensive and well-curated community resource of mouse developmental gene expression information. For many years, GXD has collected and integrated data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot, and western blot experiments through curation of the scientific literature and by collaborations with large-scale expression projects. Since our last report in 2019, we have continued to acquire these classical types of expression data; developed a searchable index of RNA-Seq and microarray experiments that allows users to quickly and reliably find specific mouse expression studies in ArrayExpress (https://www.ebi.ac.uk/arrayexpress/) and GEO (https://www.ncbi.nlm.nih.gov/geo/); and expanded GXD to include RNA-Seq data. Uniformly processed RNA-Seq data are imported from the EBI Expression Atlas and then integrated with the other types of expression data in GXD, and with the genetic, functional, phenotypic and disease-related information in Mouse Genome Informatics (MGI). This integration has made the RNA-Seq data accessible via GXD’s enhanced searching and filtering capabilities. Further, we have embedded the Morpheus heat map utility into the GXD user interface to provide additional tools for display and analysis of RNA-Seq data, including heat map visualization, sorting, filtering, hierarchical clustering, nearest neighbors analysis and visual enrichment.