Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers

Hydrophobic blocks of amphiphilic block copolymers usually form glassy micellar cores with a rigid structure that limits their applications as nanocapsules for targeted delivery. We report here on the core/shell micelles with a soft core formed<br>by self-assembly of block copolymer composed of hydrophobic and polycation blocks, poly(lauryl acrylate)-block-poly(trimethylammonioethyl acrylate) (PLA-QPDMAEA), in aqueous solution. Using scattering, microscopy and spectroscopy techniques, we showed that such copolymer forms spherical and cylindrical core/shell micelles with a fluid-like PLA core and a positively charged shell, and that these micelles can encapsulate and release hydrophobic solutes. Moreover, we discovered novel vesicle-<br>like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers formed by co-assembly of PLA-QPDMAEA core/shell micelles with another diblock copolymer composed of a hydrophilic block and polyanion block poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA). These complex structures were characterized by small-angle neutron scattering, supported by self-consistent field modeling that confirmed the formation of vesicle-like structures with dense PEO core, IPEC inner layer, PLA soft layer, IPEC outer layer and loose PEO corona. Due to their unique tunable properties, such multicompartment micelles with fluid and IPEC layers and hydrophilic corona can be used as nanocapsules with controllable thickness of each layer, charge and stability.<br>

Reversible Multilayered Vesicle-like Structures with Fluid Hydrophobic and Interpolyelectrolyte Layers

Hydrophobic blocks of amphiphilic block copolymers usually form glassy micellar cores with a rigid structure that limits their applications as nanocapsules for targeted delivery. We report here on the core/shell micelles with a soft core formed<br>by self-assembly of block copolymer composed of hydrophobic and polycation blocks, poly(lauryl acrylate)-block-poly(trimethylammonioethyl acrylate) (PLA-QPDMAEA), in aqueous solution. Using scattering, microscopy and spectroscopy techniques, we showed that such copolymer forms spherical and cylindrical core/shell micelles with a fluid-like PLA core and a positively charged shell, and that these micelles can encapsulate and release hydrophobic solutes. Moreover, we discovered novel vesicle-<br>like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers formed by co-assembly of PLA-QPDMAEA core/shell micelles with another diblock copolymer composed of a hydrophilic block and polyanion block poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA). These complex structures were characterized by small-angle neutron scattering, supported by self-consistent field modeling that confirmed the formation of vesicle-like structures with dense PEO core, IPEC inner layer, PLA soft layer, IPEC outer layer and loose PEO corona. Due to their unique tunable properties, such multicompartment micelles with fluid and IPEC layers and hydrophilic corona can be used as nanocapsules with controllable thickness of each layer, charge and stability.<br>

Hierarchical self-assembly of a PS-b-P4VP/PS-b-PNIPAM mixture into multicompartment micelles and their response to two-dimensional confinement

Finely tuned synergistic effects among different blocks could realize intriguing hierarchical self-assembly of block copolymers and such hierarchical self-assembly could be manipulated by cylindrical confinement to tune the structures of assemblies.

Synthesis and complex self-assembly of amphiphilic block copolymers with a branched hydrophobic poly(2-oxazoline) into multicompartment micelles, pseudo-vesicles and yolk/shell nanoparticles

A new PEO-b-PEHOx amphiphilic diblock copolymer was achieved which unlocked new complex self-assembled structures. Thanks to its hydrophobic oxazoline block with a long branched side chain, EHOx, various potent structures were obtained.