Exploring the paradoxes of addressing sustainability in commercial research: A study of scientist views

<p>Research scientists increasingly engage in commercial research as well as face the need to address sustainability by taking into account the social, environmental and economic consequences of development activities. This role often entails addressing contradictory imperatives. Though paradox has pervasive effects on science work and managing for sustainability, it remains underexplored in these contexts. This research is positioned at the novel intersection of three bodies of work: sustainability in the context of science work, commercial research, and paradox in management and organisation. It engages a sensemaking perspective to examine the experiences of research scientists with managing sustainability in commercial research and explicates the tensions they perceive, as well as the ways in which they respond to them. The study is primarily based on a set of 44 semi-structured interviews conducted with research scientists across four Crown Research Institutes in New Zealand. It offers two sets of findings. First, it identifies three main paradoxes research scientists perceive and elucidates their dynamics. These include the paradoxes of service ethos, role identity, and professional integrity. Second, it explicates perceived responses to these paradoxes, both constraining and productive. The former comprise the practices of opposing, isolating, over-committing, and suppressing. The latter, productive responses, consist of a range of management tactics premised on differentiation or integration. Differentiation tactics include diversification in scope of services, variation in work organisation and responsibilities, and incrementalism. Integration tactics used with external parties comprise identifying financial synergies between public and commercial projects, (re)framing problems and solutions for clients, (re)positioning across roles and identities, as well as harnessing economies of scope by co-authoring with clients. This research contributes to the literature on research management by casting the emphasis on perceived paradoxes to be navigated when addressing sustainability in commercial research. It also offers a secondary contribution to the literature on paradox in management by contextualising organisational paradoxes and their management in science work. Specifically, it provides new insight into the ways by which scientists’ engagement with sustainability cuts across ethos and shapes their views on professional integrity. It also contributes to a nuanced understanding of role identity by focusing on the tensions research scientists at Crown Research Institutes experience in the dual role of advocates of change towards sustainability and allies of business. Altogether, this work extends existing organisational research by offering insights into scientists’ experience of paradox and its management when engaging with sustainability in commercial research.</p>

Exploring the paradoxes of addressing sustainability in commercial research: A study of scientist views

<p>Research scientists increasingly engage in commercial research as well as face the need to address sustainability by taking into account the social, environmental and economic consequences of development activities. This role often entails addressing contradictory imperatives. Though paradox has pervasive effects on science work and managing for sustainability, it remains underexplored in these contexts. This research is positioned at the novel intersection of three bodies of work: sustainability in the context of science work, commercial research, and paradox in management and organisation. It engages a sensemaking perspective to examine the experiences of research scientists with managing sustainability in commercial research and explicates the tensions they perceive, as well as the ways in which they respond to them. The study is primarily based on a set of 44 semi-structured interviews conducted with research scientists across four Crown Research Institutes in New Zealand. It offers two sets of findings. First, it identifies three main paradoxes research scientists perceive and elucidates their dynamics. These include the paradoxes of service ethos, role identity, and professional integrity. Second, it explicates perceived responses to these paradoxes, both constraining and productive. The former comprise the practices of opposing, isolating, over-committing, and suppressing. The latter, productive responses, consist of a range of management tactics premised on differentiation or integration. Differentiation tactics include diversification in scope of services, variation in work organisation and responsibilities, and incrementalism. Integration tactics used with external parties comprise identifying financial synergies between public and commercial projects, (re)framing problems and solutions for clients, (re)positioning across roles and identities, as well as harnessing economies of scope by co-authoring with clients. This research contributes to the literature on research management by casting the emphasis on perceived paradoxes to be navigated when addressing sustainability in commercial research. It also offers a secondary contribution to the literature on paradox in management by contextualising organisational paradoxes and their management in science work. Specifically, it provides new insight into the ways by which scientists’ engagement with sustainability cuts across ethos and shapes their views on professional integrity. It also contributes to a nuanced understanding of role identity by focusing on the tensions research scientists at Crown Research Institutes experience in the dual role of advocates of change towards sustainability and allies of business. Altogether, this work extends existing organisational research by offering insights into scientists’ experience of paradox and its management when engaging with sustainability in commercial research.</p>

Non-commercial pharmaceutical R&D: what do neglected diseases suggest about costs and efficiency?

Background: The past two decades have witnessed significant growth in non-commercial research and development (R&D) initiatives, particularly for neglected diseases, but there is limited understanding of the ways in which they compare with commercial R&D. This study analyses costs, timelines, and attrition rates of non-commercial R&D across multiple initiatives and how they compare to commercial R&D. Methods: This is a mixed-method, observational, descriptive, and analytic study. We contacted 48 non-commercial R&D initiatives and received either quantitative and/or qualitative data from 13 organizations. We used the Portfolio to Impact (P2I) model’s estimates of average costs, timelines, and attrition rates for commercial R&D, while noting that P2I cost estimates are far lower than some previous findings in the literature. Results: The quantitative data suggested that the costs and timelines per candidate per phase (from preclinical through Phase 3) of non-commercial R&D for new chemical entities are largely in line with commercial averages. The quantitative data was insufficient to compare attrition rates. The qualitative data identified more reasons why non-commercial R&D costs would be lower than commercial R&D, timelines would be longer, and attrition rates would be equivalent or higher, though the data does not allow for estimating the magnitude of these effects. Conclusions: The quantitative data suggest that costs and timelines per candidate per phase were largely in line with (lower-end estimates of) commercial averages. We were unable to draw conclusions on overall efficiency, however, due to insufficient data on attrition rates. Given that non-commercial R&D is a nascent area of research with limited data available, this study contributes to the literature by generating hypotheses for further testing against a larger sample of quantitative data. It also offers a range of explanatory factors for further exploration regarding how non-commercial and commercial R&D may differ in costs and efficiency.

75th anniversary of S.P. Korolev Rocket and Space Corporation Energia

The article briefly discusses the key achievements of the enterprise over 75 years from the formation of OKB-1 headed by S.P. Korolev for producing intercontinental range missiles to the current status of RSC Energia being the country’s and world leader in manned space flight. The developed intercontinental missiles R-7 and a closed-loop oxygen-hydrocarbon liquid-propellant rocket engine provided the basis for developing integrated launch vehicles which were used to launch the world’s first Earth satellite, the first cosmonaut on the Earth, automatic interplanetary stations to the Moon, Venus, Mars. The diversification of the enterprise impeded S.P. Korolev to concentrate on manned space flights, and he initiated the transfer of development and manufacture of combat missiles to V.P. Makeev DB, integrated launch vehicles to TsSKB Progress, communication and other satellites to M.F. Reshetnev ISS, lunar and interplanetary stations to S.A. Lavochkin NPO. In the 1980s under the guidance of V.P. Glushko the Energia super-heavy launch vehicle and Energia–Buran system in unmanned configuration were developed and successfully launched on the first try. The Salyut manned single-module orbital stations, Mir multifunctional multi-module space laboratory and successfully operating upgraded manned transportation (Soyuz) and logistics (Progress) spacecraft were developed. In the hard times of 1990s, RSC Energia under the guidance of Yu.P. Semenov saved the national cosmonautics through commercial research performed on the Mir station. At present, RSC Energia together with Khrunichev Space Center is completing the stage of ground tests of a multipurpose laboratory module and is manufacturing modules for a promising near-Earth manned station.

The Nagoya Protocol and Access and Benefit Sharing regulations of the Convention on Biological Diversity (CBD) and its impacts on botanic gardens' collections and research.

At its 10th meeting in 2010, the Conference of the Parties of the CBD adopted the 'Nagoya Protocol (NP) on access to genetic resources and the fair and equitable sharing of benefits arising from their utilisation' which entered into force on 12 October 2014. Currently, the NP has been adopted by 129 parties, including the EU. This article reviews information retrieved from a variety of different sources dealing with the implications of Access and Benefit Sharing (ABS) regulations, including the NP, for biological collections, especially regarding material accession, conservation and research in botanic gardens. Problems encountered with adhering to ABS regulations and the NP include the following: increasing bureaucratic and administrative burdens arising from the many different ABS-related regulations at the national level; difficulties in identifying and engaging with national authorities designated as competent signatories for the NP in user and provider countries; and problems arising from ambivalent and inconsistent use of terms in the NP and in national ABS legislation. The authors encourage parties to fulfil the CBD requirement for 'simplified measures on access for non-commercial research purposes' and point out that NP-related impediments to conservation (and fundamental research) will have negative impacts on human development and biodiversity.

Understanding entertainment value: an investigation into the subjectivity of people who experience entertainment

The purpose of this doctoral dissertation and the research presented herein is to test and refine a general method of observing, capturing, describing and comparing subjective viewpoints on entertainment value. Of particular interest and equally important is the effort to provide a theoretical foundation for the conceptualization, operationalization, and empirical testing of the entertainment value concept, adopting the perspective of those experiencing performance-based and screen-based entertainment. This dissertation is also a crossover study between and among amusement, recreation, entertaining experiences, audience research, and events and live performances. Results will be integrated into the broader study of entertainment, where the core phenomenon under investigation is the entertainment experience. Entertainment value is a multi-faceted concept, widely used but poorly, or at least not effectively, operationalized for use in scholarly and commercial research. It is proposed herein that entertainment value refers to the type of value that screen-based products and live performances yield to those who experience these generic forms of entertainment. Entertainment value is perceived consumer value, experiential and subjective, a multi-dimensional concept and construct intrinsic to the entertainment experience. In three complementary studies, respondents are grouped based on shared subjective experiences resulting from the consumption of three different kinds of innovative entertainment products: a) an animated, short documentary film, b) one episode a described video television comedy; and c) a live cultural performance. In an innovative way, Stephenson’s Q Methodology (1953) and Typology of Consumer Value proposed by Morris Holbrook (1999) are adopted, tested and refined to empirically identify, describe and compare the subjective viewpoints of those who experience entertainment. The Q Methodology allowed for a rich description of a range of entertainment experiences from almost three hundred respondents. Interpretation of subjective reactions and self-reports, and the differences among these viewpoints, have been facilitated by and pointed to corresponding types of perceived entertainment value. In this sense, Holbrook’s (1999) typology for consumer value proved useful, by complementing in a number of ways the design and implementation of this exploratory research with Q methodology.

Understanding entertainment value: an investigation into the subjectivity of people who experience entertainment

The purpose of this doctoral dissertation and the research presented herein is to test and refine a general method of observing, capturing, describing and comparing subjective viewpoints on entertainment value. Of particular interest and equally important is the effort to provide a theoretical foundation for the conceptualization, operationalization, and empirical testing of the entertainment value concept, adopting the perspective of those experiencing performance-based and screen-based entertainment. This dissertation is also a crossover study between and among amusement, recreation, entertaining experiences, audience research, and events and live performances. Results will be integrated into the broader study of entertainment, where the core phenomenon under investigation is the entertainment experience. Entertainment value is a multi-faceted concept, widely used but poorly, or at least not effectively, operationalized for use in scholarly and commercial research. It is proposed herein that entertainment value refers to the type of value that screen-based products and live performances yield to those who experience these generic forms of entertainment. Entertainment value is perceived consumer value, experiential and subjective, a multi-dimensional concept and construct intrinsic to the entertainment experience. In three complementary studies, respondents are grouped based on shared subjective experiences resulting from the consumption of three different kinds of innovative entertainment products: a) an animated, short documentary film, b) one episode a described video television comedy; and c) a live cultural performance. In an innovative way, Stephenson’s Q Methodology (1953) and Typology of Consumer Value proposed by Morris Holbrook (1999) are adopted, tested and refined to empirically identify, describe and compare the subjective viewpoints of those who experience entertainment. The Q Methodology allowed for a rich description of a range of entertainment experiences from almost three hundred respondents. Interpretation of subjective reactions and self-reports, and the differences among these viewpoints, have been facilitated by and pointed to corresponding types of perceived entertainment value. In this sense, Holbrook’s (1999) typology for consumer value proved useful, by complementing in a number of ways the design and implementation of this exploratory research with Q methodology.

PSIV-11 Effects of Phytogenic Feed Additives on Growth Performance Traits of Finishing Swine

This study was conducted at a commercial research facility and utilized 1,092 finishing pigs (PIC® 337 × Camborough®) in a RCBD with 3 dietary treatments to determine the effects of commercially available phytogenic feed additives on growth performance traits in finishing swine for the last 35 d prior to marketing. The dietary treatments were as follows: 1) Control; 2) Aromex Pro® (AP; Delacon) fed at 0.01%; and 3) Ambitine® (AM; PMI) fed at 0.1%. Pens with 13 pigs/pen and 0.66 m2/pig were randomly allotted to treatments on the basis of live weight and gender. Pigs had ad libitum access to corn-soy diets that met or exceeded the pig’s requirements (NRC, 2012). Aromex Pro® and Ambitine® were added to the diets at the expense of corn. Dietary treatments started on day 0 (BW = 97.7 kg; SEM = 1.04) and were fed throughout the 35 d trial period. On d 21, the two heaviest pigs per pen were marketed, while the remaining pigs in each pen were marketed on d 35. Pigs and feeders were weighed on d 0, 21, and 35. Data were analyzed by using PROC MIXED of SAS® version 9.4, and pen was the experimental unit. The model included the fixed effect of treatment and random effect of replicate. Pre-planned orthogonal contrasts were used to compare AP vs. Control and AM vs. Control. Feeding AP or AM for the last 35 d in finishing both improved (P &lt; 0.05) ADG by 4%, ADFI by 3% and final BW by 1.6 kg over Control, but did not change feed to gain or mortality. These data demonstrate that phytogenic feed additives can improve growth performance traits in finishing swine.

277 Survey of Feedlot Nutritionists Provides Insight on How Industry Professionals Gather Practical Information

A survey of feedlot nutritionists was conducted regarding how industry professionals use published resources. Surveys were included in the spring 2020 mailing to 550 potential attendees of the Plains Nutrition Council meeting. Sixty-two responses were returned via postal service or an online survey platform (Qualtrics). Participants were asked to rank the importance of types of resources, peer-reviewed journals and learning platforms, and demographic questions. A scale of 1 to 5 was used, with 1 being not important and 5 being most important. Data were analyzed using PROC FREQ in SAS 9.4. An overwhelming majority of participants, 90%, reported serving the Plains and Midwest regions, with service split evenly between the regions. Seventy-nine percent of participants reported having a Ph.D. or other professional degree. Interestingly, 43% of participants reported having less than 16 years of professional nutritional consulting experience, and 39% reported having greater than 26 years of experience with the balance reporting in between. Of the resources offered, 87% of participants ranked peer reviewed journals as a 4 or 5, indicating they are one of the most important resources. Eighty percent of respondents found open access publications important (4 or 5), while only 49% said the same for articles accessed via membership/subscription. For Journal of Animal Science, 84% indicated an importance of 4 or 5. Not surprisingly, 75% responded as being a member of ASAS but only 34% responded as attending national or sectional ASAS meetings. This suggests a large population uses memberships for journals and other resources, but not for meetings. Participants were able to write in additional resources they find valuable, and 9 of 14 participants who listed additional resources responded with some form of in-house or commercial research. Through these data, feedlot nutrition researchers can better understand how to reach intended audiences in future publications.

151 A Web Application to Establish Customized Feeding Program and Nutrient Specifications for Highly Prolific Sows

A web application was developed to provide a dynamic feeding program for PIC maternal dam lines during gilt development, gestation, peri-partum, lactation and wean-to-service interval (WSI). These recommendations for each production phase are based on peer-reviewed large-scale commercial research. The tool was developed using the Shiny package of R and includes CSS themes, html widgets, and JavaScript actions. Inputs, include pigs weaned per sow per year (PWSY), farrowing rate (FR), total born (TB), replacement rate, the existing feeding program of the breeding herd and the diet energy and standardized ileal digestible (SID) lysine (Lys) levels. Outputs include the feeding program, nutrient specifications and estimates of economic opportunity and performance improvement. The feeding program is based on user-defined energy and SID Lys levels for the gestation and lactation diets and the PIC nutrient recommendations for the breeding herd. Correspondingly, recommended specifications of other nutrients in the diets are provided and calculated based on the recommended feeding program. The tool provides economic and productivity opportunity analysis by comparing the PIC recommendations and the current user feeding programs. Improvement in PWSY is driven by the energy intake impact on caliper score during breeding and farrowing and consequently to FR and TB. This web application can be used by nutritionists and production managers to compare their current feeding practices to PIC recommendations for highly prolific sows. This will aid in their decision-making process regarding nutrition and feeding programs considering productivity and profitability outcomes.