Bias-based harassment, or harassment based on one’s actual or perceived social identity, such as sexual orientation, remains a prominent concern in many schools. Homophobic harassment is one form of bias-based harassment evident in schools. Not only is homophobic harassment common compared to non–bias-based victimization, it also carries distinct and elevated consequences for those who experience it. Given the seriousness of homophobic harassment and the consequences of experiencing it, this chapter addresses three key issues. First, it provides a review of individual and contextual factors that underlie homophobic behavior and its perpetuation over time. Second, the chapter describes the various processes by which homophobic victimization predicts health and academic concerns for lesbian, gay, bisexual, transgender, questioning, and heterosexual youth. Finally, the chapter covers several factors that may promote resilience among youth who experience this form of victimization. Each section notes implications for research, practice, and policy.