Determination of the potential capacity of the point of primary processing of livestock products (on the example of basin groups of the Arctic zone of Yakutia)

Relevance. Currently, there is a need to develop proposals for the creation of a vertically integrated system of procurement stations with modern slaughterhouses in the Arctic zone of the Republic of Sakha (Yakutia). The methodology for determining the potential capacity of a primary processing point for animal products allows planning the rational placement of production facilities, their state regulation and financing.Methods. At the research we used such methods as monographic, economic and statistical, graphic, computational and constructive methods. The potential capacities are determined on the basis of the necessary equality between the monthly capacity according to the schedule of arrival of animals from agricultural producers and the monthly productivity of the point according to capacity.Results. The article provides a brief analysis of the development of agriculture in the Arctic regions, which are divided into the Anabarskaya, Prilenskaya, Yanskaya, Indigirskaya, Kolymskaya groups of uluses (districts) according to the basin principle of the main navigable rivers. The strategic directions of the development of branches of the agro-industrial complex in the north of Yakutia are considered. The methodology and results of calculating the potential capacity of primary processing points in each group of uluses based on the number of reindeer, horses and cattle (cattle) and seasonality of slaughter and daily capacity for initial planning are presented. According to the results of the study, it is proved that to ensure a relatively full load during the year (except for the summer period) the primary processing centers in the Arctic zone of RS (Ya) can be of small and medium capacity. The layout scheme of the centers for processing livestock products is proposed, taking into account the further optimal increase in performance with capacities: 25 heads per shift — in v. Saskylakh, Anabarsky ulus (district) and Deputatsky settlement, Ust-Yansky ulus; 10 heads per shift — in u.v. Tiksi, Bulunsky ulus and u.v. Chersky, Nizhnekolymsky ulus; 7 heads per shift — inv. Khonuu, Momsky ulus.

The forward edge transference within self-psychology and the activation of inborn capacity through interpretation and internalization

This paper builds on the ideas of self-psychologists Marian Tolpin and Richard Geist in two ways. Firstly, the idea of using forward edge transference as fostering the promotion of psychological health and well-being. I present two verbatim clinical examples showing the use of forward edge transference, and thus the intersubjective engagement between therapist and patient. I suggest that forward edge transference, rooted in healthy and self-affirming childhood experiences, can lie buried and forgotten. Secondly, using the same two examples, this paper adopts the notion of interpretation as a carrier of selfobject functions and shows how the interpretation of forward edge transferences has the potential to catalyse (forgotten) inborn capacity. Internalization, a part of selfobject function and psychic development, is re-thought of as a process in which an interaction between patient and therapist appears to (re)activate inborn potential/capacity for the patient rather than as something the patient ‘takes in’ from the other/selfobject.

Visfatin and Resveratrol Differentially Regulate the Expression of Thymidylate Synthase to Control the Sensitivity of Human Colorectal Cancer Cells to Capecitabine Cytotoxicity

Colorectal cancer (CRC) is a highly lethal malignant cancer. Capecitabine, a 5-fluororacil (5-FU) derivate, is its first-line drug, but the resistance of CRC to capecitabine is still the most challenging factor for curing patients. It has been suggested that thymidylate synthase (TYMS) level might affect the capecitabine efficacy in CRC patients, but the mechanism still needs more elucidation. Obesity is a risk factor for CRC. Recently, a correlation between serum visfatin, an obesity-elicited adipokine, and CRC development has been found. Thus, the aim of present study is to examine the visfatin capacity in TYMS expression and in the development of capecitabine resistance of CRC. Moreover, an attractive natural component, i.e., resveratrol, has been proposed in anticancer therapy and has hence been examined in the present study to see its potential capacity in the alleviation of CRC resistance. Our results found that visfatin significantly reduces the CRC sensitivity to capecitabine by controlling the TYMS expression via p38 signaling and Sp1 transcription factor. Moreover, resveratrol could significantly alleviate the visfatin effect on capecitabine-treated CRC cells. These results provided new insights to understand the capecitabine susceptibility of CRC under a visfatin-containing environment and a possible therapeutic application of resveratrol in CRC patients with obesity.

Diversity in the observed functionality of dams and reservoirs

Knowledge and modeling of the observed functionality of dams and reservoirs are desirable for better water resources management. In this study, we examine the functionality of dams and reservoirs over much of the globe through a hydroclimate assessment over 990 Global Runoff Data Center stations that have at least one dam/reservoir over the corresponding drainage areas and available streamflow records of at least 25 years. To quantify the potential capacity of human disturbance/alteration, annual cumulative maximum storage (CMS) of the dams are computed and then annual potential changes in the residence time of water (PRT; CMS divided by annual mean monthly flow) are assessed. In addition, the Man-Kendall tests for annual maximum, mean, and minimum monthly streamflow, and drainage area-averaged precipitation are conducted. Results show that the size of CMS and the main purpose have an explanatory power of the designed hydrologic response (i.e., flattening of the seasonality) while 6% of dam-affected stations experienced the opposite hydrologic response (intensifying of the seasonality) due to the overwhelming impact of anthropogenic climate change. This study finds that the magnitude of PRT is a potential indicator to identify a considerable impact of dams and reservoirs for the regional hydrologic regime. The findings of this study suggest diversity in the observed functionality of dams and reservoirs, which is still a challenge in global hydrological modeling.

The use of sorption and excess sorption isotherm in the mathematical modeling of the unsteady-state heat and humidity regime of the building envelope

In the given article the development of the moisture transfer equation based on the theory of moisture potential is considered. The task of combined heat and moisture transfer is one of the most complicated tasks in the building thermal physics field. The classical equations of moisture transfer by K.F. Fokin representing the transfer of moisture under the action of partial transfer potentials - the gradient of the partial pressure of water vapor and the gradient of humidity F - are listed. The possibility of uniform accounting of the combined water vapor transfer on the basis of the moisture potential F is described. The sorption isotherm for aerated concrete is constructed in accordance with the experiment carried out in a desiccator with an aqueous solution of sulfuric acid. A new equation of moisture transfer which takes into account moistening with vaporous moisture in the sorption zone of moisture and liquid moisture in the excess sorption zone of moisture is derived. In order to simplify the work with the obtained equation a new value of the relative potential capacity is introduced. A graph construction of sorption and excess sorption isotherms which are obtained using an analytical expression for the relative potential capacity is proposed. In the sorption zone of humidification the sorption and excess sorption isotherms coincide with the classical sorption isotherm. Meanwhile, in the excess sorption zone of humidification the sorption and excess sorption isotherms depend on temperature.

Diagnosing the Business Development during Strategizing

Introduction. As a rule, strategic plans use the potential plant capacity to adapt the enterprise to adverse conditions, and these plans require constant adjustment. Strategic plans that rely on insufficient information about pant capacity may result in significant financial losses for the company. The research objective was to develop a principle for diagnosing sustainable growth based on potential capacity. Study objects and methods. The research featured three metallurgical enterprises, since metallurgy is of strategic importance for the domestic industrial development. The study involved such standard methods as system and situational analysis, expert assessments, correlation analysis, regression analysis, topological analysis, and statistical simulation. Results and discussion. The authors proposed an algorithm for calculating three types of potential capacity indicators: relative added value and revenue (y1), situational potential (y2) and performance (y3). The new methods made it possible to forecast the indicators of sustainable development and compare the mode of operation with standard value, i.e. the length of the estimated vector, which exceeded or equaled a certain fraction of its maximum possible value. If the vector length was less than this value, the stability started to decrease. The performance indicator demonstrated if the enterprise reached the maximal value of the indicator when it exceeded the boundary of the sustainability standard. Conclusion. The new approach provided a prompt assessment and forecast of the potential plan capacity. It could improve the forecast of potential instability, increase the flexibility of strategic plans, and prevent strategic shock.

Extraction optimization and microencapsulation of Berberine from Berberis vulgaris incorporated in a functional orange drink: Physiochemical attributes and kinetic release studies

BACKGROUND: Berberine, extracted from Berberis vulgaris, is one of the well-known natural antioxidant sources. OBJECTIVE: Optimizing the berberine extraction conditions from the whole Barberry plant and microencapsulation of the optimized extract to be used as a bioactive ingredient in functional orange juice. METHODS: Seventeen extraction processes were designed to determine an optimized method for producing an ethanol/water extract with maximum yield, safety, and antioxidant properties. The optimal extract was microencapsulated by complex coacervation using tragacanth/gelatin and then spray-dried. The selected microcapsules based on morphology, particle size, and solubility were added to orange juice, and the physical and sensory properties of the functional drink, as well as the kinetic release models, were analyzed. RESULTS: An optimal extract with 82%antioxidant activity was prepared using a 75%ethanol/water ratio and an extraction time of 0.5 h at 22.3°C. Spherical-shaped microcapsules could create a desirable cloudy appearance with good stability in the pH of orange juice. The kinetics of the berberine release revealed an initial burst phase followed by a prolonged one, which would appeal to consumers’ sensory perceptions. CONCLUSIONS: The excellent compatibility between berberine and orange juice provides a potential capacity to fortify a high-consumption drink with a phytonutrient presented in a berry fruit.

Potential and Realized Absorptive Capacity in Colombian Firms: The Mediating Role of the Organizational Climate for Innovation

The absorptive capacity is related to knowledge evaluation and acquisition (Potential Capacity), as well as to the transformation and exploitation of such knowledge (Realized Capacity). This research aims to analyze the absorptive capacity in Colombian companies and to investigate whether the Realized capacity can be predicted from the Potential capacity. Likewise, due to the importance of the context on the absorptive capacity development, the mediating role of the organizational climate for innovation was tested. Through a cross-sectional study, a total of 260 employees from different companies completed the Absorptive Capacity Scale and the Organizational Climate for Innovation Scale. The results showed that Potential absorptive capacity is needed for Realized absorptive capacity, additionally, organizational climate for innovation exerted a mediator role in this transition. These findings highlight that companies should have an organizational climate that allows them to acquire and transform knowledge in order to increase their innovativeness and be more competitive. Further studies should analyze the organizational innovation in relation to the proposed and tested model, while considering employees from different industrial sectors.

QHAR: Q-Holonic-Based ARchitecture for Self-Configuration of Cyber–Physical Production Systems

Production systems must be able to adapt to increasingly frequent internal and external changes. Cyber-Physical Production Systems (CPPS), thanks to their potential capacity for self-reconfiguration, can cope with this need for adaptation. To implement the self-reconfiguration functionality in economical and safe conditions, CPPS must have appropriate tools and contextualized information. This information can be organized in the form of an architecture. In this paper, after the analysis of several holonic and nonholonic architectures, we propose a holonic architecture that allows for reliable and efficient reconfiguration. We call this architecture QHAR (Q-Holonic-based ARchitecture). QHAR is constructed based on the idea of a Q-holon, which has four dimensions (physical, cyber, human, and energy) and can exchange three flows (energy, data, and materials). It is a generic Holon that can represent any entity or actor of the supply chain. The QHAR is structured in three levels: centralized control level, decentralized control level, and execution level. QHAR implements the principle of an oligarchical control architecture by deploying both hierarchical and heterarchical control approaches. This ensures the overall system performance and reactivity to hazards. The proposed architecture is tested and validated on a case study.